Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Bovine, Pig (tested or 100% immunogen sequence identity)
ELISA (1:1000 - 1:10000)
Specificity and Use
Highly pure calf intestinal alkaline phosphatase.
Recognizes calf intestinal alkaline phosphatase- (IAP), a membrane-bound hydrolase enzyme highly expressed by intestinal mucosa. Alkaline phosphatase (AP) is a ubiquitously expressed enzyme which removes phosphate groups from target molecules, including DNA, RNA and alkaloids, under alkaline conditions, and is present at higher concentrations in the placenta (placental AP), intestines (intestinal AP) and liver/bone/kidney (tissue non-specific AP). In vivo studies have identified CIAP as a potential therapeutic agent for the treatment of lipopolysaccharide (LPS)-mediated inflammation and sepsis, due to the ability of IAP to neutralize and thereby detoxify LPS.
Western Blot: LS-C55818 detects a band of approximately 67kD in porcine microvillar membranes.