Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a beta -catenin-dependent manner. Yang Z, Hai B, Qin L, Ti X, Shangguan L, Zhao Y, Wiggins L, Liu Y, Feng JQ, Chang JY, Wang F, Liu F. Molecular and cellular biology. 2013 Dec;33:4732-44. [Full Text Article]
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
BMPR1A -C180 western blot of HeLa cell line lysates (35 ug/lane). The BMPR1A antibody detected the BMPR1A protein (arrow).
Requested From: United States
Date Requested: 2/22/2017