Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(tested or 100% immunogen sequence identity)
IHC (1:500 - 1:5000)
ICC (1:500 - 1:5000)
Western blot (1:500 - 1:5000)
ELISA (1:500 - 1:5000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
ALDP / ABCD1 antibody was raised against aLDP1 fragment from aa 279 to 482 as a fusion protein.
Human ALDP. No cross-reactivity with mouse ALDRP, PMP70. Cross-reactivity to an unidentified 80kD MW protein is present in lymphoblastoid cells, but not in several other cells or tissues tested.
ELISA: 1:500-1:5000. Western Blot: 1:500-1:5000. Immunohistochemistry: 1:500-1:5000. Immunocytochemistry: 1:500-1:5000. Can be used to analyze ALDP protein in cells and tissues from normal individuals, or from patients with adrenoleukodystrophy (ALD) or Zellweger syndrome and related peroxisomal diseases, and provides an excellent marker for peroxisomes (Mosser et al. 1994). About 70% of ALD male patients have no detectable ALDP in fibroblasts or leukocytes. A similar proportion of carrier females may show mosaicism for the presence or absence of ALDP.
Ascites without preservative.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
ALDP / ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle.