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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ALDP / ABCD1 Antibody (aa279‑482) LS‑C11823
ABCD1 antibody LS-C11823 is an unconjugated mouse monoclonal antibody to human ABCD1 (ALDP). Validated for ELISA, ICC, IHC and WB.
Antibody
Catalog
Size
Price
LS-C11823-100
100 µl
$770

Popular ALDP / ABCD1 Products

Anti-ABCD1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7120 concentration 5 ug/ml.
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Western blot analysis of ABCD1 expression in HeLa (A); mouse brain (B); rat kidney (C) whole cell lysates.
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Antibody
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IHC of paraffin-embedded Human liver tissue using anti-ABCD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Species: Human
Applications: IHC, IHC - Paraffin, Western blot

Product Description

ABCD1 antibody LS-C11823 is an unconjugated mouse monoclonal antibody to human ABCD1 (ALDP). Validated for ELISA, ICC, IHC and WB.

Specifications

Target
Human ALDP / ABCD1
Synonyms
ABCD1, ABC42, Adrenoleukodystrophy protein, ALD, Aldgh, Adrenoleukodystrophy, ALDP, X-ALD
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated
Purification
Ascites
Modifications
Unmodified
Applications
  • IHC (1:500 - 1:5000)
  • ICC (1:500 - 1:5000)
  • Western blot (1:500 - 1:5000)
  • ELISA (1:500 - 1:5000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
ALDP / ABCD1 antibody was raised against aLDP1 fragment from aa 279 to 482 as a fusion protein.
Epitope
aa279-482
Specificity
Human ALDP. No cross-reactivity with mouse ALDRP, PMP70. Cross-reactivity to an unidentified 80kD MW protein is present in lymphoblastoid cells, but not in several other cells or tissues tested.
Usage
ELISA: 1:500-1:5000. Western Blot: 1:500-1:5000. Immunohistochemistry: 1:500-1:5000. Immunocytochemistry: 1:500-1:5000. Can be used to analyze ALDP protein in cells and tissues from normal individuals, or from patients with adrenoleukodystrophy (ALD) or Zellweger syndrome and related peroxisomal diseases, and provides an excellent marker for peroxisomes (Mosser et al. 1994). About 70% of ALD male patients have no detectable ALDP in fibroblasts or leukocytes. A similar proportion of carrier females may show mosaicism for the presence or absence of ALDP.
Presentation
Ascites without preservative.
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About ALDP / ABCD1
ALDP / ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. P33897 NM_000033 NP_000024.2


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Requested From: United States
Date Requested: 10/21/2018

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