Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Bovine (tested or 100% immunogen sequence identity)
Mouse, Dog, Pig (at least 90% immunogen sequence identity)
Western blot (1 - 3 µg/ml)
Specificity and Use
AKAP8 / AKAP95 antibody was raised against synthetic peptide DQGYGGYGAWSAG-C from the N-terminus of human AKAP8 (NP_005849.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Bovine (100%); Mouse, Elephant, Dog, Pig (92%); Rat, Mosquito (85%).
AKAP8 / AKAP95 is a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin.