Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
AGTR1, AG2S, AGTR1A, AGTR1B, Angiotensin II type-1 receptor, Ang ii receptor type 1a, Angiotensin receptor 1, Angiotensin receptor 1a, Angiotensin receptor 1B, AT1R, AT1 receptor, At1a receptor, AT1B, AT1AR, AT2R1, AT2R1A, AT2R1B, HAT1R, AT1, At1a, At1b receptor, AT1BR, Type-1 angiotensin II receptor
Rat, Human, Mouse, Pig, Rabbit
(tested or 100% immunogen sequence identity)
Dog, Sheep (at least 90% immunogen sequence identity)
Western blot (1:1000 - 1:5000)
ELISA (1:10000 - 1:100000)
Synthetic peptide 10aa sequence the N-terminus, extracellular of rat AT II (1) (KLH coupled).
Recognizes rat Angiotensin II type 1 Receptor. Sequence is the same in all AT II receptor isoforms (Type 1a, 1b and 1c). No sequence homology with other G-protein coupled receptors. Species sequence homology: Mouse, human, porcine, sheep, canine, chimpanzee and rabbit: 100%.
Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence.
PBS, 0.05% Sodium Azide
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Type 1 Angiotensin Receptors (AT1A and AT1B) mediate the major cardiovascular effects of angiotensin II, controlling blood pressure and volume by regulating cell growth, vascular contraction, inflammatory responses, and salt and water retention.