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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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AGAP2 / PIKE
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts with nuclear phosphoinositide 3-kinase (PI3 kinase) to stimulate its lipid kinase activity. PIKE exists in multiple isoforms; a shorter C-terminal isoform (PIKE-A) has also been identified as centaurin gamma 1. The longest isoform (PIKE-L) has been shown to bind to the adaptor protein Homer and thereby link to metabotropic glutamate receptors, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Overexpression of PIKE-A enhances Akt activity and promotes cancer cell invasion, whereas decreased expression of PIKE-A via dominant negative expression of PIKE-A or PIKE-A knockdown inhibits these processes. In many human cancers, expression of PIKE-A is enhanced, leading to increased Akt activity and preventing apoptosis. Also known as: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.
| Gene Name: | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
| Family/Subfamily: | Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806 |
| Synonyms: | AGAP2, AGAP-2, Centaurin, gamma 1, Cnt-g1, Centaurin-gamma-1, KIAA0167, GGAP2, PIKE, CENTG1 |
| Target Sequences: | NM_014770 NP_055585.1 Q99490 |
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