ADRBK1 / GRK2

adrenergic, beta, receptor kinase 1

Beta-adrenergic receptor kinase (ADRBK1) phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. The ADRBK1 gene spans approximately 23 kb and is composed of 21 exons. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by the beta-AR kinase (beta-ARK1), an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. Inhibition of ADRBK1 is a novel mode of therapy.

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Products

Antibodies (66)

ELISA Kits (9)

Proteins (8)

Type

Cell-Based (2)

Cell-Based Phosphorylation (2)

Over-Expression Lysate (2)

Primary (66)

Recombinant (6)

Sandwich (5)

Target

ADRBK1 / GRK2 (83)

Reactivity

Human (67)

Mouse (50)

Rat (44)

Bat (7)

Bovine (11)

Chimpanzee (6)

Dog (8)

Gibbon (3)

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Horse (7)

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IHC (28)

IHC-P (14)

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ELISA (25)

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IF (4)

Peptide-ELISA (5)

Host

rabbit (57)

mouse (8)

goat (1)

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IHCPlus (2)

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IgG (28)

IgG1 (4)

IgG1,k (1)

IgG2b (1)

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monoclonal mc (8)

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96-Well Microplate (4)

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10-90 aa (1)

570-650 aa, C-terminal (1)

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Yes (1)

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Adherent Cell Cultures (4)

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6His-SUMO, N-terminus (1)

GST (1)

His (1)

His-GST (2)

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Species

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Source

293T Cells (1)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (2)

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Low endotoxin level (1)

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ADRBK1 / GRK2 Antibody (phospho-Ser29) LS-C351799

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (pSer29) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

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Mouse ADRBK1 / GRK2 (Sandwich ELISA) ELISA Kit - LS-F32085

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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IHC-plus™ ADRBK1 / GRK2 Antibody LS-B12295

(4.0) Rating

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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ADRBK1 / GRK2 Antibody (clone 3F8) LS-C169349

Antibody:

ADRBK1 / GRK2 Mouse anti-Human Monoclonal (3F8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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ADRBK1 / GRK2 Antibody (phospho-Ser685) LS-C199027

(4.0) Rating

(1) Publication(s)

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (pSer685) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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ADRBK1 / GRK2 Antibody (aa633-660) LS-C98902

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (aa633-660) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Mouse/Human/Rat Phospho-ADRBK1 / GRK2 (Ser685) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1720

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat ADRBK1 / GRK2 (Cell-Based ELISA) ELISA Kit - LS-F3075

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Human ADRBK1 / GRK2 (Sandwich ELISA) ELISA Kit - LS-F9317

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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IHC-plus™ ADRBK1 / GRK2 Antibody (clone 5D5) LS-B225

(4.0) Rating

Antibody:

ADRBK1 / GRK2 Mouse anti-Human Monoclonal (5D5) Antibody

Reactivity:

Bovine, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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ADRBK1 / GRK2 Antibody (N-Terminus) LS-C358899

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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ADRBK1 / GRK2 Antibody LS-C193022

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$391; 100 µl/$489

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ADRBK1 / GRK2 Antibody (clone 3F8) LS-C758930

Antibody:

ADRBK1 / GRK2 Mouse anti-Human Monoclonal (3F8) Antibody

Reactivity:

Mouse, Rat, Primate, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$541

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ADRBK1 / GRK2 Antibody (Thr23) LS-C176319

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (Thr23) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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ADRBK1 / GRK2 Antibody (620-700 aa) LS-C381057

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (620-700 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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ADRBK1 / GRK2 Antibody (C-Terminus) LS-C351803

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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ADRBK1 / GRK2 Antibody (aa398-640, Biotin) LS-C686843

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (aa398-640) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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ADRBK1 / GRK2 Antibody LS-C812631

Antibody:

ADRBK1 / GRK2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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ADRBK1 / GRK2 Antibody LS-C665992

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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Mouse ADRBK1 / GRK2 Protein (Recombinant 6His-SUMO, N-terminus) (aa1-689) - LS-G57608

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Human ADRBK1 / GRK2 Protein (Recombinant His) (Full Length) - LS-G22082

Source:

E. coli

Tag:

His

Molecular Weight:

29.7 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ADRBK1 / GRK2 (Sandwich ELISA) ELISA Kit - LS-F32528

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse/Human/Rat ADRBK1 / GRK2 (Cell-Based ELISA) ELISA Kit - LS-F2028

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

ADRBK1 / GRK2 Antibody (phospho-Ser29) LS-C199026

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (pSer29) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

ADRBK1 / GRK2 Antibody LS-C331619

Antibody:

ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539

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