Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey (tested or 100% immunogen sequence identity)
Western blot (0.1 - 0.3 µg/ml)
IHC - Paraffin
Specificity and Use
ADRB2 antibody was raised against synthetic peptide C-HQGTVPSDNIDSQ from the C-terminus of human ADRB2 (NP_000015.1). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Chimpanzee (92%); Bovine (85%).
Clenbuterol and formoterol decrease force production in isolated intact mouse skeletal muscle fiber bundles through a beta2-adrenoceptor-independent mechanism. McCormick C, Alexandre L, Thompson J, Mutungi G. Journal of applied physiology (Bethesda, Md. : 1985). 2010 Dec;109:1716-27. [Full Text Article]
ADRB2 is beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor.