ADD2

adducin 2 (beta)

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.

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Products

Antibodies (23)

Proteins (10)

ELISA Kits (1)

Type

Cell-Based (1)

Over-Expression Lysate (6)

Primary (23)

Recombinant (4)

Target

ADD2 (34)

Reactivity

Human (24)

Mouse (10)

Rat (8)

Bovine (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Horse (3)

Monkey (3)

Orangutan (3)

Application

WB (23)

ELISA (3)

ICC (1)

IF (6)

IP (3)

Peptide-ELISA (3)

Host

rabbit (22)

mouse (1)

Isotype

IgG (21)

Clonality

polyclonal pc (23)

Format

96-Well Microplate (1)

APC Conjugated (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (15)

Epitope

aa648-697 (4)

440-520 aa, Internal (1)

Glu497 (1)

Internal (1)

aa1-50 (1)

aa448-497 (1)

aa471-520 (1)

aa550-600 (1)

aa600-650 (1)

Publications

No (34)

Sample Type

Adherent Cell Cultures (1)

Tag

GST (1)

Myc-DDK (Flag) (9)

Species

Human (7)

Source

293T Cells (3)

HEK 293 Cells (6)

Wheat Germ Extract (1)

Purification

Purified (1)

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ADD2 Antibody (Internal) LS-C413165

Antibody:

ADD2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$321

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ADD2 Antibody (440-520 aa, Internal) LS-C381918

Antibody:

ADD2 Rabbit anti-Human Polyclonal (440-520 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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ADD2 Antibody LS-C823370

Antibody:

ADD2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

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ADD2 Antibody (aa471-520) LS-C119380

Antibody:

ADD2 Rabbit anti-Human Polyclonal (aa471-520) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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ADD2 Antibody LS-C804625

Antibody:

ADD2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

ADD2 Antibody (Glu497) LS-C177037

Antibody:

ADD2 Rabbit anti-Human Polyclonal (Glu497) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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ADD2 Antibody LS-C664390

Antibody:

ADD2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

ADD2 Antibody (aa1-50) LS-C290398

Antibody:

ADD2 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

ADD2 Antibody (aa600-650) LS-C290397

Antibody:

ADD2 Rabbit anti-Human Polyclonal (aa600-650) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

ADD2 Antibody (aa550-600) LS-C290396

Antibody:

ADD2 Rabbit anti-Human Polyclonal (aa550-600) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

ADD2 Antibody (aa448-497) LS-C200089

Antibody:

ADD2 Rabbit anti-Human Polyclonal (aa448-497) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

ADD2 Antibody LS-C309329

Antibody:

ADD2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

Select

ADD2 Antibody (HRP) LS-C540738

Antibody:

ADD2 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$937

Select

ADD2 Antibody (Biotin) LS-C520605

Antibody:

ADD2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$937

Select

ADD2 Antibody (FITC) LS-C530649

Antibody:

ADD2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$937

Select

ADD2 Antibody (PE) LS-C648851

Antibody:

ADD2 Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$937

Select

ADD2 Antibody (APC) LS-C512390

Antibody:

ADD2 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$937

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

Select

ADD2 Antibody (aa648-697) LS-C102423

Antibody:

ADD2 Rabbit anti-Human Polyclonal (aa648-697) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

ADD2 Antibody (aa648-697, HRP) LS-C455970

Antibody:

ADD2 Rabbit anti-Human Polyclonal (aa648-697) (HRP) Antibody

Reactivity:

Dog, Bovine, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

ADD2 Antibody (aa648-697, Biotin) LS-C455968

Antibody:

ADD2 Rabbit anti-Human Polyclonal (aa648-697) (Biotin) Antibody

Reactivity:

Dog, Bovine, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

ADD2 Antibody (aa648-697, FITC) LS-C455969

Antibody:

ADD2 Rabbit anti-Human Polyclonal (aa648-697) (FITC) Antibody

Reactivity:

Dog, Bovine, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

ADD2 Antibody LS-C410559

Antibody:

ADD2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

ADD2 Antibody LS-C306106

Antibody:

ADD2 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

Select

Human ADD2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65556

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.7 kDa

Price:

20 µg/$1,107

Select

Human ADD2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65558

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.3 kDa

Price:

20 µg/$1,107

Viewing 1-25 of 34 product results

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