Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ADCY8 Antibody, AC8 Antibody, Adenylate cyclase type VIII Antibody, Adenylate cyclase, type viii Antibody, Adenylate cyclase 8 (brain) Antibody, Adenylate cyclase type 8 Antibody, Adenylyl cyclase 8 Antibody, ATP pyrophosphate-lyase 8 Antibody, Adenylyl cyclase-8, brain Antibody, HBAC1 Antibody
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase
Formalin-fixed and paraffin-embedded mouse brain tissue reacted with ADCY8 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of ADCY8 Antibody in HL-60 cell line lysates (35 ug/lane). ADCY8 (arrow) was detected using the purified antibody.
ADCY8 Antibody flow cytometry of HL-60 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.