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ADAM33 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Name: | ADAM metallopeptidase domain 33 |
Family/Subfamily: | Protease , Metallopeptidase M12B |
Synonyms: | ADAM33, C20orf153, DJ964F7.1, ADAM 33 |
Target Sequences: | NM_025220 NP_079496.1 Q9BZ11 |
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