The Immunohistochemistry Antibody Company
|Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit (tested or 100% immunogen sequence identity)|
|ADAM15 antibody was raised against synthetic peptide located between aa540-589 of human ADAM15 (Q71S69, NP_997079). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Monkey, Marmoset, Mouse, Rat (100%); Galago (92%); Bovine, Bat (85%); Elephant, Horse, Pig (84%).|
|Western Blot: Suggested dilution at 1µg/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody. ELISA titer in peptide based assay: 1:62500.|
|Lyophilized from PBS with 2% sucrose|
|Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than one week): +4°C. Avoid repeat freeze-thaw cycles.|
|For research use only.|
ADAM15 Antibody, ADAM 15 Antibody, MDC15 Antibody, Metargidin Antibody, MDC-15 Antibody, TMDC VI AntibodyActive metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation.