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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ADAM10 Antibody (PE) LS‑C124903
Antibody
ADAM10 antibody LS-C124903 is a PE-conjugated mouse monoclonal antibody to human ADAM10. Validated for Flow.
Catalog
Size
Price
LS-C124903-100
100 tst
Unavailable

Popular ADAM10 Products

Immunocytochemical staining of K562 cells using ADAM10 antibody at 2 µg/ml.
Species: Human
Applications: IHC, ICC, Western blot
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Applications: IHC, Western blot, ELISA
Antibody
Species: Human
Applications: Flow Cytometry
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: Western blot

Product Description

ADAM10 antibody LS-C124903 is a PE-conjugated mouse monoclonal antibody to human ADAM10. Validated for Flow.
About ADAM10
Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. O14672 NM_001110 NP_001101.1

ADAM10 Antibody, AD10 Antibody, ADAM 10 Antibody, Kuzbanian Antibody, HsT18717 Antibody, CD156c Antibody, CD156c antigen Antibody, CDw156 Antibody, Kuz Antibody, Kuzbanian protein homolog Antibody, MADM Antibody


Specifications

Target
Human ADAM10
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2b Monoclonal
Conjugations
Phycoerythrin. Also available conjugated with APC, CF.
Purification
Purified
Modifications
Unmodified
Applications
  • Flow Cytometry
  • (applications tested for the base form of this product only)
Immunogen
ADAM10 antibody was raised against mouse myeloma cell line NS0-derived recombinant human ADAM10 corresponding to aa 214-672 (UniProt Accession # O14672).
Specificity
Recognizes the ectodomain of human ADAM10.
Usage
Suitable for use in Flow cytometry: Intracellular staining antibodies are designed for multiparameter flow cytometric analysis of cells. To stain for surface proteins (e. g. CD3, CD4, CD8) in addition to the intracellular protein, we recommend that the investigator determine whether the fixation and permeabilization steps adversely affect the surface protein. If so, surface staining of cells prior to fixation and permeabilization is recommended. For intracellular staining, cells must first be fixed and permeabilized. Use of 4% paraformaldehyde in PBS as a fixative is recommended. Other formulations or tissue fixatives may affect the staining properties of the monoclonal antibody. For permeabilization, 0.1% saponin in a balanced salt solution is effective in facilitating antibody entry into cells. Due to the reversible nature of cell membrane permeabilization, saponin must be included in all buffers used (i. e. both the staining and washing steps). The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Presentation
PBS, 0.1% sodium azide
Storage
May be stored at 4°C for short-term only. For long-term storage and to avoid freeze-thaw cycles, aliquot and store at -20°C. Aliquots are stable for at least 1 year at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/24/2018

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