Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
This Activin A Receptor Type IC (ACVR1C) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human Activin A Receptor Type IC (ACVR1C).
PBS, 0.09% sodium azide
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
ACVR1C Antibody, Activin receptor-like kinase 7 Antibody, ACTR-IC Antibody, Activin receptor type IC Antibody, ACVRLK7 Antibody, Activin receptor type-1C Antibody, ALK7 Antibody, Activin A receptor, type IC Antibody, ALK-7 Antibody
ALK7, a Activin/TGFb type protein kinase, is a member of the Nodal signaling pathway, which is implicated in developmental events such as mesoderm formation and left-right axis specification. ALK7 is a type I receptor that has been shown to collaborate with activin receptor type 2B (ActRIIB). A constitutively active form of ALK7 has been shown to increase phosphorylation of Smad2, a receptor-regulated signaling protein which translocate to the nucleus to activate transcription.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of anti-ACVR1C Antibody (N-term A48) in HepG2 and HeLa cell line lysate (35 ug/lane). ACVR1C (arrow) was detected using the purified antibody.
Requested From: United States
Date Requested: 2/27/2017