Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 22D3] (IgG1) to Human ACTC1 / Alpha Cardiac Actin
Human, Rat, Goat, Pig, Rabbit
IHC - Frozen, Western blot, ELISA
Human ACTC1 / Alpha Cardiac Actin
Human, Rat, Goat, Pig, Rabbit (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [22D3]
IHC - Frozen (1:100 - 1:1000)
Western blot (1:1000 - 1:5000)
IHC - Paraffin
Specificity and Use
ACTC1 / Alpha Cardiac Actin antibody was raised against peptide comprising the N-terminal nonapeptide of a-cardiac actin with an acetylated N-terminus (Ac-DDEETTALVC-COOH) coupled to keyhole limpet hemocyanin through the cysteine residue.
Highly specific for alpha-cardiac actin, and does not cross react with other actin isoforms.
PBS containing 0.09% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus.