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ACLY / ATP Citrate Lyase
ATP citrate lyase
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
| Gene Name: | ATP citrate lyase |
| Synonyms: | ACLY, ACL, ATP citrate synthase, ATPCL, ATP citrate lyase, ATP-citrate (pro-S-)-lyase, CLATP, ATP-citrate synthase, Citrate cleavage enzyme, Citrate Lyase |
| Target Sequences: | NM_001096 NP_001087.2 P53396 |
Publications (2)
1
Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. King FW, Fong S, Griffin C, Shoemaker M, Staub R, Zhang YL, Cohen I, Shtivelman E. PloS one. 2009 4:e7283. (WB)
[PubMed:19789631]
[PMC:PMC2747272]
2
Hypoxia further exacerbates woody breast myopathy in broilers via alteration of satellite cell fate. Nima K Emami, Reagan N Cauble, Ahmed E Dhamad, Elizabeth S Greene, Cynthia S Coy, Sandra G Velleman, Sara Orlowski, Nicholas Anthony, Mike Bedford, Sami Dridi. Poultry science. 2021 Jul;;100:101167. [Full Text Article]
[PubMed:34091348]
[PMC:PMC8182261]
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ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Rat, Pig, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
ACLY / ATP Citrate Lyase Mouse anti-Human Monoclonal (5F8D11) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal (aa350-400) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
ACLY / ATP Citrate Lyase Mouse anti-Human Monoclonal (3G8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$485
ACLY / ATP Citrate Lyase Mouse anti-Human Monoclonal (C-Terminus) Antibody
Human
Flo, ICC, IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal (pSer454) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ACLY / ATP Citrate Lyase Mouse anti-Human Monoclonal (Amino Acid: 306-502) (5F8D11) Antibody
Mouse, Rat, Non-Human Primate, Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µg/$503
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal Antibody
Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
ACLY / ATP Citrate Lyase Mouse anti-Human Monoclonal (Carrier-free) (3G8) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IP, WB
Unconjugated
100 µg/$331
ACLY / ATP Citrate Lyase Mouse anti-Human Monoclonal Antibody
Chicken, Sheep, Bovine, Rat, Pig, Mouse, Human
Flo, IF, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
ACLY / ATP Citrate Lyase Mouse anti-Human Monoclonal Antibody
Mouse, Human
Flo, ICC, WB
Unconjugated
100 µl/$391
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
1.56 - 100 IU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal (pSer454) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
100 µl/$450
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal (390-470 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal (390-470 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal Antibody
Rat, Human
Flo, IHC-P, WB
Unconjugated
100 µg/$575
ACLY / ATP Citrate Lyase Mouse anti-Human Monoclonal Antibody
Mouse, Human, Monkey
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$412
ACLY / ATP Citrate Lyase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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