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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ACKR1 / DARC Antibody (C‑Terminus) LS‑C121174
Antibody
DARC antibody LS-C121174 is an unconjugated rabbit polyclonal antibody to DARC (ACKR1) from human, mouse and rat. Validated for IHC and WB.
Catalog
Size
Price
LS-C121174-100
100 µg (1 mg/ml)
Unavailable

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Western blot. All lanes: ACKR1 antibody at 2 ug/ml Lane 1:mouse kidney tissue. Lane 2mouse spleen tissue. Secondary antibody: Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 36 kDa. Observed band size: 36 kDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Product Description

DARC antibody LS-C121174 is an unconjugated rabbit polyclonal antibody to DARC (ACKR1) from human, mouse and rat. Validated for IHC and WB.
About ACKR1 / DARC
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Q16570 NM_002036 NP_002027.2

ACKR1 Antibody, CD234 Antibody, CD234 antigen Antibody, DARC Antibody, Duffy antigen Antibody, Duffy blood group Antibody, Duffy group antigen Antibody, Dfy Antibody, FY Antibody, Fy glycoprotein Antibody, Plasmodium vivax receptor Antibody, WBCQ1 Antibody, CCBP1 Antibody, Duffy blood group antigen Antibody, Glycoprotein D Antibody, GPD Antibody, GpFy Antibody


Specifications

Target
Human ACKR1 / DARC
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (2.5 µg/ml)
  • Western blot (1 - 2 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
ACKR1 / DARC antibody was raised against synthetic peptide corresponding to 16aa sequence from near the carboxy terminus of Human CD234.
Epitope
C-Terminus
Specificity
Detects CD234 in mouse brain tissue lysate at ~23 and 36kD. Species cross-reactivity: Mouse, rat.
Usage
Suitable for use in Western Blot, Immunohistochemistry. Western Blot: 1-2 ug/ml. Immunohistochemistry (Paraffin): 2.5 ug/ml.
Presentation
PBS, pH 7.2, 0.02% sodium azide
Storage
May be stored at 4°C for short-term only. For long-term storage and to avoid freeze-thaw cycles, aliquot and store at -20°C. Aliquots are stable for at least 1 year at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/21/2018

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