Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 3C5] (IgG1) to Human ACE / CD143
IHC - Paraffin, Western blot, ELISA
Human ACE / CD143
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [3C5]
Tissue culture supernatant
IHC - Paraffin
Specificity and Use
ACE / CD143 antibody was raised against denatured human kidney CD143 (Angiotensin converting enzyme).
Recognizes human CD143, also known as angiotensin - converting enzyme (ACE). CD143 exists in two forms, a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of arterioles and lung capillaries), epithelial cells (especially in proximal renal tubules and in the small intestine), by some neuronal cells and variably on some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa.
Tissue culture supernatant, 0.09% sodium azide
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
ACE Antibody, ACE1 Antibody, Angiotensin-converting enzyme Antibody, CD143 Antibody, CD143 antigen Antibody, Carboxycathepsin Antibody, DIPEPTIDYL CARBOXYPEPTIDASE Antibody, DCP Antibody, Dipeptidyl carboxypeptidase I Antibody, ICH Antibody, Kininase II Antibody, MVCD3 Antibody, Peptidyl-dipeptidase A Antibody, Peptidase P Antibody, DCP1 Antibody, Dipeptidyl carboxypeptidase 1 Antibody, Testicular ECA Antibody
ACE / CD143 is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system.