The Immunohistochemistry Antibody Company
|Human (tested or 100% immunogen sequence identity)|
|AATF antibody was raised against the epitope recognized by this antibody maps to a region between residue 125 and 175 of human apoptosis antagonizing transcription factor (Che-1) using the numbering given in entry NP_036270.1 (GeneID 26574).|
|Species cross-reactivity: Human. Other species have not been tested.|
|Suitable for use in Western Blot and Immunoprecipitation. Western Blot: 2-5 ug/mg lysate. Immunoprecipitation: 2-5 ug/mg lysate.|
|TBS, pH 7.2, 0.1% BSA, 0.1% sodium azide.|
|For research use only.|
AATF Antibody, CHE1 Antibody, DED Antibody, Rb-binding protein Che-1 Antibody, CHE-1 Antibody, Protein AATF AntibodyMay function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression.