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A2M / Alpha-2-Macroglobulin

alpha-2-macroglobulin

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Gene Name: alpha-2-macroglobulin
Synonyms: A2M, CPAMD5, A2MD, FWP007, Alpha-2-M, Alpha-2-macroglobulin, S863-7
Target Sequences: NM_000014 NP_000005.2 P01023

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Antibodies (159)
ELISA Kits (28)
Proteins (16)
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Development Kit (1)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
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A2M / Alpha-2-Macroglobulin (203)
Human (98)
Mouse (31)
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A2M / Alpha-2-Macroglobulin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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A2M / Alpha-2-Macroglobulin Sheep anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P
Unconjugated
0.5 ml/$515
A2M / Alpha-2-Macroglobulin Antibody - Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
A2M / Alpha-2-Macroglobulin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IE, IHC, IHC-P
Unconjugated
250 µg/$535
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A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$379
A2M / Alpha-2-Macroglobulin Antibody - Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
A2M / Alpha-2-Macroglobulin Antibody - Anti-Alpha-2-Macroglobulin / A2M antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Rabbit, Dog, Pig, Human
ELISA, IE, IHC, IHC-P, IP
Unconjugated
0.5 mg/$440
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
625 - 40000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
6.17 - 500 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$617
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
9.38 - 600 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$757
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal (HRP) Antibody
Rabbit, Dog, Pig, Human
ELISA, IE
HRP Conjugated
100 µg/$611
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal (Biotin) Antibody
Human
ICC, WB
Biotin Conjugated
50 µg/$1,042
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
0.156 - 10 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$685
A2M / Alpha-2-Macroglobulin Antibody - Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$866
A2M / Alpha-2-Macroglobulin Antibody - Anti-A2M / Alpha-2-Macroglobulin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal (aa417-430) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
10 ml/$508
A2M / Alpha-2-Macroglobulin Antibody - Immunohistochemistry of paraffin-embedded human endometrial cancer at dilution of 1:100
Select
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
A2M / Alpha-2-Macroglobulin Antibody - Western blot of recombinant Alpha-2-Macroglobulin / A2M.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
A2M / Alpha-2-Macroglobulin Rabbit anti-Pig Polyclonal (aa1097-1357) Antibody
Pig
WB
Unconjugated
100 µl/$323; 200 µl/$371; 500 µl/$531; 1 ml/$617; 2 ml/$850; 5 ml/$1,401
A2M / Alpha-2-Macroglobulin Antibody - Western Blot; Sample: Recombinant a2M, Human.
Select
A2M / Alpha-2-Macroglobulin Mouse anti-Human Monoclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$303; 200 µl/$343; 500 µl/$475; 1 ml/$541; 2 ml/$712; 5 ml/$1,177
A2M / Alpha-2-Macroglobulin Antibody - Immunohistochemistry of Macroglobulin alpha-2 antibody
Select
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
Viewing 1-25 of 203 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).