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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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AGER / RAGE Antibody (aa174‑192) LS‑C389151
RAGE antibody LS-C389151 is an unconjugated rabbit polyclonal antibody to RAGE (AGER) from human, mouse, rat and other species. Validated for IHC and WB.
Catalog
Size
Price
LS-C389151-100
100 µg (0.5 mg/ml)
$415
Description
RAGE antibody LS-C389151 is an unconjugated rabbit polyclonal antibody to RAGE (AGER) from human, mouse, rat and other species. Validated for IHC and WB.
Target
Human AGER / RAGE
Host
Rabbit
Reactivity
Human, Mouse, Rat, Guinea pig (tested or 100% immunogen sequence identity)
Predicted
Bat, Hamster, Horse, Rabbit (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (0.5 - 1 µg/ml)
  • IHC - Frozen (0.5 - 1 µg/ml)
  • Western blot (0.5 - 1 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
AGER / RAGE antibody was raised against synthetic peptide from the middle region of human RAGE (KEQTRRHPETGLFTLQSEL, aa174-192 of UniProt Q15109). Percent identity by BLAST analysis: Human, Guinea pig (100%); Bat, Hamster, Rabbit, Horse (95%); Pig, Dog (89%).
Epitope
aa174-192
Specificity
Human AGER / RAGE
Usage
The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimers disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
Reconstitution
0.2 ml Sterile distilled water
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About AGER / RAGE
Q15109 NM_001136 NP_001127.1

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Images

Immunohistochemistry

IHC-P: RAGE antibody testing of rat lung tissue
IHC-P: RAGE antibody testing of rat lung tissue

Western blot

Western blot testing of RAGE antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng
Western blot testing of RAGE antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng

Immunohistochemistry

IHC-P: RAGE antibody testing of rat lung tissue
IHC-P: RAGE antibody testing of rat lung tissue

Western blot

Western blot testing of RAGE antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng
Western blot testing of RAGE antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng

Immunohistochemistry

IHC-P: RAGE antibody testing of rat lung tissue
IHC-P: RAGE antibody testing of rat lung tissue

Western blot

Western blot testing of RAGE antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng
Western blot testing of RAGE antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng

Immunohistochemistry

IHC-P: RAGE antibody testing of rat lung tissue
IHC-P: RAGE antibody testing of rat lung tissue

Western blot

Western blot testing of RAGE antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng
Western blot testing of RAGE antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng

Requested From: United States
Date Requested: 12/17/2018
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