RAGE antibody LS-C389151 is an unconjugated rabbit polyclonal antibody to RAGE (AGER) from human, mouse, rat and other species. Validated for IHC and WB.
Human, Mouse, Rat, Guinea pig
(tested or 100% immunogen sequence identity)
Bat, Hamster, Horse, Rabbit (at least 90% immunogen sequence identity)
- IHC - Paraffin (0.5 - 1 µg/ml)
- IHC - Frozen (0.5 - 1 µg/ml)
- Western blot (0.5 - 1 µg/ml)
See our complete line of Immunohistochemistry Reagents
including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
AGER / RAGE antibody was raised against synthetic peptide from the middle region of human RAGE (KEQTRRHPETGLFTLQSEL, aa174-192 of UniProt Q15109). Percent identity by BLAST analysis: Human, Guinea pig (100%); Bat, Hamster, Rabbit, Horse (95%); Pig, Dog (89%).
Human AGER / RAGE
The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimers disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
0.2 ml Sterile distilled water
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
For research use only.