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ADAM8

ADAM metallopeptidase domain 8

ADAM8 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.

Gene Name: ADAM metallopeptidase domain 8
Family/Subfamily: Protease , Metallopeptidase M12B
Synonyms: ADAM8, ADAM metallopeptidase domain 8, Cell surface antigen MS2, ADAM 8, MS2, CD156, CD156a antigen
Target Sequences: NM_001109 NP_001100.3 P78325

Publications (3)

1
N-glycosylation regulates ADAM8 processing and activation. Srinivasan S, Romagnoli M, Bohm A, Sonenshein GE. The Journal of biological chemistry. 2014 289:33676-88. (WB; Human) [Full Text Article] [PubMed:25336660] [PMC:PMC4246118] Related Antibodies: LS-B4068.
2
miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. Das SG, Romagnoli M, Mineva ND, Barillé-Nion S, Jézéquel P, Campone M, Sonenshein GE. Breast cancer research : BCR. 2016 18:40. (WB; Human) [Full Text Article] [PubMed:27039296] [PMC:PMC4818899] Related Antibodies: LS-B4068.
3
ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg Á, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE. EMBO molecular medicine. 2014 Feb;6:278-294. (IHC; Human) [Full Text Article] [PubMed:24375628] [PMC:PMC3927960] Related Antibodies: LS-B4068.

☰ Filters
Antibodies (41)
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ADAM8 Antibody - Anti-ADAM8 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ADAM8 Antibody - Human spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ADAM8 Rabbit anti-Mouse Polyclonal (aa145-493) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
ADAM8 Antibody - Staining (2 ug/ml) of Human Brain lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by chemiluminescence.
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ADAM8 Goat anti-Human Polyclonal (aa813-824) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
ADAM8 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ADAM8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ADAM8 Antibody - ADAM8 antibody Western blot of PANC1 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADAM8 Rabbit anti-Human Polyclonal (aa70-119) Antibody
Human
WB
Unconjugated
100 µl/$424
ADAM8 Protein - Recombinant A Disintegrin And Metalloprotease 8 By SDS-PAGE
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E. coli
His, N-Terminal
42.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
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ADAM8 Mouse anti-Human Monoclonal (aa158-653) Antibody
Human
ELISA, Flo, IP, WB
Unconjugated
500 µg/$1,099
ADAM8 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ADAM8 Rabbit anti-Human Polyclonal (aa371-587) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ADAM8 Antibody - Immunohistochemistry (IHC) analysis of ADAM8 antibody in paraffin-embedded human breast carcinoma tissue at 1:50, showing cytoplasm staining. Negative control (the right) using PBS instead of primary antibody. Secondary antibody is Goat Anti-Rabbit IgG-biotin.
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ADAM8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$431
ADAM8 Antibody - Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CD156 mouse mAb with DAB staining.
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ADAM8 Mouse anti-Human Monoclonal (2C1F3) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µg/$459
ADAM8 Antibody - Immunofluorescence analysis of Hela cells using CD156 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
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ADAM8 Mouse anti-Human Monoclonal (3B10D7) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µg/$459
ADAM8 Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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ADAM8 Rabbit anti-Human Polyclonal (aa126-155) Antibody
Human
WB
Unconjugated
200 µl/$734
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ADAM8 Rabbit anti-Human Polyclonal (aa126-155) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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ADAM8 Rabbit anti-Human Polyclonal (aa126-155) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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ADAM8 Rabbit anti-Human Polyclonal (aa126-155) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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ADAM8 Rabbit anti-Human Polyclonal (aa126-155) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
ADAM8 Antibody - ADAM8 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The ADAM8 antibody detected the ADAM8 protein (arrow).
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ADAM8 Rabbit anti-Human Polyclonal (aa126-155) Antibody
Human
WB
Unconjugated
400 µl/$393
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ADAM8 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
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ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
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ADAM8 Mouse anti-Human Monoclonal (aa158-653) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$930; 500 µg/$1,795
ADAM8 Antibody - 1:100 staining rat colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ADAM8 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ADAM8 Antibody - Immunofluorescence analysis of HeLa cells using ADAM8 antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$412
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ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
Viewing 1-25 of 64 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).