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ACE2 / ACE-2
angiotensin I converting enzyme 2
Angiotensin-Converting Enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE2 is also the attachment receptor for HCoV-N63, SARS-CoV and SARS-CoV-2. The S1 portion of the coronavirus spike protein attaches to ACE2 presented on the host cell surface. The SARS-CoV-2 virus targets pneumocytes and macrophages expressing ACE2 in the lung, and it is believed to infect ACE2-positive cells in other tissues including the gastrointestinal tract and potentially the liver (in cholangiocytes).
| Gene Name: | angiotensin I converting enzyme 2 |
| Family/Subfamily: | Protease , Metallopeptidase M2 |
| Synonyms: | ACE2, ACE-related carboxypeptidase, ACEH, Metalloprotease MPROT15, SARS-CoV2 Coronavirus Receptor, SARS-CoV-2 Coronavirus Receptor, COVID-19 viral receptor |
| Target Sequences: | NM_021804 NP_068576.1 Q9BYF1 |
Publications (10)
1
Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. Adedeji AO, Severson W, Jonsson C, Singh K, Weiss SR, Sarafianos SG. Journal of virology. 2013 87:8017-28. (IHC; Human)
[Full Text Article]
[PubMed:23678171]
[PMC:PMC3700180]
Related Antibodies: LS-C122669.
2
Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension. Francine Duchatsch, Paula B Constantino, Naiara A Herrera, Mayara F Fabrício, Lidieli P Tardelli, Aline M Martuscelli, Thiago J Dionísio, Carlos F Santos, Sandra L Amaral. Journal of the American Society of Hypertension : JASH. 2018 August;12:605-613. [Full Text Article]
[PubMed:29945776]
3
Reduced severe acute respiratory syndrome coronavirus 2 entry factors and enhanced innate immune gene expression in the nasal epithelium of pregnant rats. Arvind Palanisamy, Tusar Giri. American journal of obstetrics and gynecology. 2020 October; [Full Text Article]
[PubMed:33039392]
[PMC:PMC7544630]
Related Antibodies: LS-C763699.
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ACE2 / ACE-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
0.05 mg/$545
ACE2 / ACE-2 Rabbit anti-Human Polyclonal (aa140-172) Antibody
Human
IHC-P
Unconjugated
200 µl/$460
ACE2 / ACE-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
ACE2 / ACE-2 Mouse anti-Human Monoclonal (aa18-237) (1G4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ACE2 / ACE-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC-P, WB
Unconjugated
0.05 mg/$545
ACE2 / ACE-2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$321
ACE2 / ACE-2 Rabbit anti-Human Polyclonal (aa684-733) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ACE2 / ACE-2 Rabbit anti-Human Polyclonal (aa684-733) (HRP) Antibody
Pig, Orangutan, Gibbon, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
ACE2 / ACE-2 Mouse anti-Human Monoclonal (AC18F) Antibody
Human
ELISA, Flo, IHC-P, WB
Unconjugated
50 µg/$344; 100 µg/$393
ACE2 / ACE-2 Mouse anti-Human Monoclonal (Biotin) (AC18F) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
50 µg/$393
ACE2 / ACE-2 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$307; 120 µl/$367; 200 µl/$457
ACE2 / ACE-2 Goat anti-Human Polyclonal (aa18-740) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$962
Sandwich
96-Well Microplate
Human
0.39 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$537
Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$856
Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ACE2 / ACE-2 Mouse anti-Human Monoclonal (aa18-740) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$860
ACE2 / ACE-2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Human Cells
Mouse IgG1 Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
110 kDa
20 µg/$685; 100 µg/$1,523
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ACE2 / ACE-2 Rabbit anti-Human Polyclonal (aa140-172) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
ACE2 / ACE-2 Rabbit anti-Human Polyclonal (aa140-172) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
ACE2 / ACE-2 Rabbit anti-Human Polyclonal (aa140-172) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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