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ACAN / Aggrecan
aggrecan
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
| Gene Name: | aggrecan |
| Synonyms: | ACAN, AGCAN, Aggrecan core protein, Acg1, Aggrecan, CSPG1, CSPGCP, CSPCP, AGC1, Aggrecan 1, Large aggregating proteoglycan, MSK16, SEDK, MCSPG |
| Target Sequences: | NM_013227 NP_037359.3 P16112 |
Publications (5)
1
Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otterness IG, Flannery CR, Caterson B. Matrix biology : journal of the International Society for Matrix Biology. 2002 21:271-88.
[PubMed:12009333]
2
A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs. Swearingen CA, Chambers MG, Lin C, Marimuthu J, Rito CJ, Carter QL, Dotzlaf J, Liu C, Chandrasekhar S, Duffin KL, Mitchell PG, Durham TB, Wiley MR, Thirunavukkarasu K. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2010 18:1159-66. (WB; Bovine, Human, Rat)
[PubMed:20633676]
3
Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, Kurosaka M, Nishida K. Arthritis research & therapy. 2012 14:R51. (IHC; Rat)
[PubMed:22394620]
[PMC:PMC3446417]
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(8)
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(1)
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(2)
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(1)
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Low endotoxin level
(1)
Fast Shipping
ACAN / Aggrecan Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rat, Hamster, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
ACAN / Aggrecan Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Hamster, Pig, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
ACAN / Aggrecan Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC-P
Unconjugated
50 µg/$460
ACAN / Aggrecan Rabbit anti-Human Polyclonal (aa350-400) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 ml/$386
ACAN / Aggrecan Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
ACAN / Aggrecan Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
ACAN / Aggrecan Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
ACAN / Aggrecan Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
ACAN / Aggrecan Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
Competitive EIA
96-Well Strip Plate
Rat
100 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$798
E. coli
His
20.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$3,361
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$856
ACAN / Aggrecan Mouse anti-Human Monoclonal (7D4) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.2 mg/$545
ACAN / Aggrecan Rabbit anti-Human Monoclonal (Cleaved-Asp369) Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
ACAN / Aggrecan Rabbit anti-Human Polyclonal (aa34-147) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
ACAN / Aggrecan Mouse anti-Human Monoclonal (aa20-675) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
500 µg/$1,083
ACAN / Aggrecan Mouse anti-Human Monoclonal (7E1) Antibody
Human
ELISA, IHC, IHC-Fr, IP, WB
Unconjugated
0.2 mg/$471
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum, Urine
1 Plate/$718
E. coli
His
14.1 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Biological Fluids, Plasma, Serum, Tissue Homogenates
1 Plate/$783
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HEK 293 Cells
None
Less than 0.1 EU/µg protein (determined by LAL method).
This 672 amino acid recombinant protein with a C-terminal His tag has a predicted molecular mass of approximately 74.3 kD. The protein migrates at about 100 kD by SDS-PAGE in DTT-reducing and non-reducing conditions. The predicted N-terminal amino acid is
25 µg/$375; 100 µg/$731
ACAN / Aggrecan Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
500 µg/$631
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of 129
product results
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