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ABCB4 / MDR3

ATP-binding cassette, sub-family B (MDR/TAP), member 4

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Family/Subfamily: Transporter , ATP-binding cassette - ABCB/MDR
Synonyms: ABCB4, ABC21, ICP3, GBD1, MDR3, MDR2, Multidrug resistance protein 3, Multiple drug resistance 3, P-glycoprotein 3, Pgy2, PGY3, PFIC-3, MDR2/3
Target Sequences: NM_018849 NP_061337.1 P21439

Publications (3)

1
Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model. Weber ND, Odriozola L, Martínez-García J, Ferrer V, Douar A, Bénichou B, González-Aseguinolaza G, Smerdou C. Nature communications. 2019 December;10:5694. [Full Text Article] [PubMed:31836711] [PMC:PMC6910969] Related Antibodies: LS-B5729.
2
Sensing Acute Cellular Rejection in Liver Transplant Patients Using Liver-Derived Extracellular Particles: A Prospective, Observational Study. Kaan Kamali, Moritz Schmelzle, Can Kamali, Philipp Brunnbauer, Katrin Splith, Annekatrin Leder, Nadja Berndt, Karl-Herbert Hillebrandt, Nathanael Raschzok, Linda Feldbrügge, Matthäus Felsenstein, Joseph Gaßner, Paul Ritschl, Georg Lurje, Wenzel Schöning, Christian Benzing, Johann Pratschke, Felix Krenzien. Frontiers in immunology. 2021 May;12:647900. [Full Text Article] [PubMed:34025656] [PMC:PMC8131523] Related Antibodies: LS-C694886.
3
ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth. Kiehl S, Herkt SC, Richter AM, Fuhrmann L, El-Nikhely N, Seeger W, Savai R, Dammann RH. Scientific reports. 4:6899. [Full Text Article] [PubMed:25367630] [PMC:PMC4219162] Related Antibodies: LS-B5729.

☰ Filters
Antibodies (32)
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Primary (32)
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ABCB4 / MDR3 (38)
Human (21)
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WB (23)
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ELISA (11)
ICC (1)
IF (1)
Peptide-ELISA (1)
rabbit (27)
mouse (5)
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IHCPlus (4)
IgG (12)
IgG1,k (1)
IgG2b (2)
monoclonal mc (5)
polyclonal pc (27)
1808CT346.21.23 (1)
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aa1-20 (1)
aa601-720 (1)
aa629-692 (1)
No (36)
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Tissue Homogenates (2)
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E. coli (2)
ABCB4 / MDR3 Antibody - Anti-ABCB4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCB4 / MDR3 Rabbit anti-Human Polyclonal (aa252-301) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ABCB4 / MDR3 Antibody - Anti-ABCB4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCB4 / MDR3 Rabbit anti-Human Polyclonal (aa252-301) (HRP) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
ABCB4 / MDR3 Antibody - Anti-ABCB4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCB4 / MDR3 Rabbit anti-Human Polyclonal (aa252-301) (Biotin) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
ABCB4 / MDR3 Antibody - Anti-ABCB4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCB4 / MDR3 Rabbit anti-Human Polyclonal (aa252-301) (FITC) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
ABCB4 / MDR3 Antibody - ABCB4 antibody IHC-paraffin: Mouse Intestine Tissue.
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ABCB4 / MDR3 Rabbit anti-Human Polyclonal (aa601-720) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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ABCB4 / MDR3 Mouse anti-Human Monoclonal (Concentrated) (P3II-26) Antibody
Human
IHC, IHC-Fr, WB
Unconjugated, Concentrated
1 ml/$537
ABCB4 / MDR3 Antibody - WB of ABCB4 / MDR3 antibody. WB: MCF-7 Cell Lysate.
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ABCB4 / MDR3 Rabbit anti-Human Polyclonal (aa1-20) Antibody
Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
ABCB4 / MDR3 Antibody - Anti-ABCB4 Antibody at 1:4000 dilution + MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 142 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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ABCB4 / MDR3 Mouse anti-Human Monoclonal (1808CT346.21.23) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
ABCB4 / MDR3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
ABCB4 / MDR3 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ABCB4 / MDR3 Mouse anti-Human Monoclonal (Concentrated) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated, Concentrated
0.05 ml/$460
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ABCB4 / MDR3 Mouse anti-Human Monoclonal (Ready-to-Use) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$523
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ABCB4 / MDR3 Mouse anti-Human Monoclonal (aa629-692) (P3II-26) Antibody
Human
Flo, ICC, IHC, IHC-Fr, WB
Unconjugated
1 ml/$860
ABCB4 / MDR3 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ABCB4 / MDR3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC-P
Unconjugated
50 µg/$460
ABCB4 / MDR3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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ABCB4 / MDR3 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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ABCB4 / MDR3 Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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ABCB4 / MDR3 Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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ABCB4 / MDR3 Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
ABCB4 / MDR3 Antibody - Western Blot; Sample: Recombinant protein.
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ABCB4 / MDR3 Rabbit anti-Mouse Polyclonal Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
ABCB4 / MDR3 Antibody - Western Blot; Sample: Recombinant protein.
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ABCB4 / MDR3 Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
ABCB4 / MDR3 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ABCB4 / MDR3 Rabbit anti-Human Polyclonal Antibody
Mouse
IHC-P, WB
Unconjugated
50 µl/$460
ABCB4 / MDR3 Protein - Recombinant ATP Binding Cassette Transporter B4 (ABCB4) by SDS-PAGE
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E. coli
His-T7, N-terminus
30.3kDa
10 µg/$272; 50 µg/$387; 200 µg/$772; 100 µg/$620; 1 mg/$1,834; 500 µg/$1,393; 5 mg/$2,794; 2 mg/$2,016
ABCB4 / MDR3 Antibody - Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue  using ABCB4 Polyclonal Antibody at dilution of 1:70(×200)
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ABCB4 / MDR3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ABCB4 / MDR3 Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using ABCB4 Polyclonal Antibody at dilution of 1:40(×200)
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ABCB4 / MDR3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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ABCB4 / MDR3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Viewing 1-25 of 38 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).