A2ML1

alpha-2-macroglobulin-like 1

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.

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Products

Antibodies (20)

Proteins (5)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (20)

Recombinant (3)

Sandwich (1)

Target

A2ML1 (26)

Reactivity

Human (21)

Mouse (7)

Application

IHC (1)

IHC-P (1)

WB (17)

Flo (7)

ELISA (10)

Host

rabbit (19)

mouse (1)

Isotype

IgG (11)

Clonality

polyclonal pc (20)

Format

96-Well Strip Plate (1)

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (5)

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Epitope

aa1119-1348 (8)

aa345-373 (7)

Publications

No (26)

Sample Type

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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A2ML1 Antibody (aa1119-1348) LS-C292752

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa1119-1348) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141

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A2ML1 Antibody (aa1119-1348, HRP) LS-C708756

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa1119-1348) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$325; 200 µl/$375; 500 µl/$539; 1 ml/$632; 2 ml/$867; 5 ml/$1,439

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A2ML1 Antibody (aa1119-1348, Biotin) LS-C685296

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa1119-1348) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217

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A2ML1 Antibody (aa1119-1348, FITC) LS-C691735

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa1119-1348) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$334; 200 µl/$387; 500 µl/$565; 1 ml/$682; 2 ml/$919; 5 ml/$1,549

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A2ML1 Antibody (aa1119-1348, PE) LS-C722816

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa1119-1348) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213

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A2ML1 Antibody (aa1119-1348, APC, Cy7) LS-C731814

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa1119-1348) (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$476; 200 µl/$590; 500 µl/$1,069; 1 ml/$1,265; 2 ml/$1,771; 5 ml/$3,319

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A2ML1 Antibody (aa1119-1348, APC) LS-C739271

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa1119-1348) (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213

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A2ML1 Antibody (aa1119-1348, Cy3) LS-C699731

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa1119-1348) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC, Cy7
• APC
• More...
  • Cy3

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC, Cy7
  • APC
  • Cy3

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A2ML1 Antibody LS-C682147

Antibody:

A2ML1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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A2ML1 Antibody (HRP) LS-C677031

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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A2ML1 Antibody (Biotin) LS-C677030

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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A2ML1 Antibody (FITC) LS-C677033

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

A2ML1 Antibody (aa345-373) LS-C319228

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa345-373) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

200 µl/$734

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A2ML1 Antibody (aa345-373, Biotin) LS-C250506

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa345-373) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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A2ML1 Antibody (aa345-373, FITC) LS-C250507

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa345-373) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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A2ML1 Antibody (aa345-373, APC) LS-C250505

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa345-373) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

APC Conjugated

Price:

200 µl/$952

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A2ML1 Antibody (aa345-373, Azide-free, HRP) LS-C250508

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa345-373) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

A2ML1 Antibody (aa345-373, PE) LS-C250509

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa345-373) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

A2ML1 Antibody (aa345-373) LS-C155823

Antibody:

A2ML1 Rabbit anti-Human Polyclonal (aa345-373) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

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A2ML1 Antibody LS-C306012

Antibody:

A2ML1 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

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A2ML1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106923

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

161 kDa

Price:

100 µg/$710

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Human A2ML1 Protein (Recombinant GST) (Full Length) - LS-G36638

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

44.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human A2ML1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G73266

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

161 kDa

Price:

20 µg/$1,107

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Human A2ML1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G94788

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

161 kDa

Price:

20 µg/$215

Select

Human A2ML1 (Sandwich ELISA) ELISA Kit - LS-F4892

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$764

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