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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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Additional Contact Details
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TMPRSS3
transmembrane protease, serine 3
TMPRSS3 is a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.
| Gene Name: | transmembrane protease, serine 3 |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | TMPRSS3, DFNB10, ECHOS1, Serine protease TADG-12, TADG12, DFNB8 |
| Target Sequences: | NM_024022 NP_076927.1 P57727 |
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