SLX4

SLX4 structure-specific endonuclease subunit

Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.

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Products

Antibodies (7)

Type

Primary (7)

Target

SLX4 (7)

Reactivity

Human (7)

Monkey (3)

Application

IHC (2)

IHC-P (1)

WB (4)

IP (2)

Host

rabbit (7)

Product Group

IHCPlus (1)

Isotype

IgG (3)

Clonality

polyclonal pc (7)

Format

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (4)

Epitope

aa100-149 (4)

aa1784-1834 (2)

aa1650-1700 (1)

Publications

No (7)

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IHC-plus™ SLX4 Antibody (aa1784-1834) LS-B12395

(4.0) Rating

Antibody:

SLX4 Rabbit anti-Human Polyclonal (aa1784-1834) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP

Format:

Unconjugated

Price:

50 µl/$460

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SLX4 Antibody (aa100-149) LS-C135640

Antibody:

SLX4 Rabbit anti-Human Polyclonal (aa100-149) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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SLX4 Antibody (aa100-149, HRP) LS-C466836

Antibody:

SLX4 Rabbit anti-Human Polyclonal (aa100-149) (HRP) Antibody

Reactivity:

Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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SLX4 Antibody (aa100-149, Biotin) LS-C466835

Antibody:

SLX4 Rabbit anti-Human Polyclonal (aa100-149) (Biotin) Antibody

Reactivity:

Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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SLX4 Antibody (aa100-149, FITC) LS-C466834

Antibody:

SLX4 Rabbit anti-Human Polyclonal (aa100-149) (FITC) Antibody

Reactivity:

Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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SLX4 Antibody (aa1784-1834) LS-C286850

Antibody:

SLX4 Rabbit anti-Human Polyclonal (aa1784-1834) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

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SLX4 Antibody (aa1650-1700) LS-C289020

Antibody:

SLX4 Rabbit anti-Human Polyclonal (aa1650-1700) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

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