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Unfortunately, the antibody LS-C187990 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



RAB7A / RAB7 Antibodies

RAB7A, member RAS oncogene family

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. RAB7A encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.

Gene Name: RAB7A, member RAS oncogene family
Synonyms: RAB7A Antibody, CMT2B Antibody, PRO2706 Antibody, RAB7 Antibody, Ras-associated protein RAB7 Antibody, Ras-related protein Rab-7a Antibody, PSN Antibody
Target Sequences: NM_004637 AAA86640.1 P51149
 RAB7A / RAB7 Feature Table
Featured Image

Featured RAB7A / RAB7 Antibody

LS-B1789 is a rabbit polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.


RAB7A / RAB7 Antibodies (13)

Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
RAB7A / RAB7 Rabbit Polyclonal Unconjugated Human, Chimpanzee, Monkey, Rat, Bovine, Dog, Chicken, Xenopus, Zebrafish IHC-P, WB aa90-140 No Primary
Anti-RAB7A / RAB7 Antibody (aa90-140) IHC-plus™ LS-B1789
IHC Image
WB Image
Rabbit Polyclonal to Human RAB7A / RAB7
Human, Chimpanzee, Monkey, Rat, Bovine, Dog, Chicken, Xenopus, Zebrafish
IHC - Paraffin, Western blot
Unconjugated
RAB7A / RAB7 Rabbit IgG Monoclonal EPR7588(B) Unconjugated Human, Mouse, Rat IHC-P, ICC, WB Internal No Primary
Anti-RAB7A / RAB7 Antibody (Internal, clone EPR7588(B)) IHC-plus™ LS-B8106
IHC Image
WB Image
Rabbit Monoclonal [clone EPR7588(B)] (IgG) to Human RAB7A / RAB7
Human, Mouse, Rat
IHC - Paraffin, ICC, Western blot
Unconjugated
RAB7A / RAB7 Rabbit Polyclonal Unconjugated Human IHC-P, WB, Flo aa178-207 No Primary
Anti-RAB7A / RAB7 Antibody (aa178-207) LS-C162393
IHC Image
Flo Image
Rabbit Polyclonal to Human RAB7A / RAB7
Human
IHC - Paraffin, Western blot, Flow Cytometry
Unconjugated
RAB7A / RAB7 Rabbit Polyclonal Unconjugated Human IHC, WB No Primary
Anti-RAB7A / RAB7 Antibody LS-C175838
IHC Image
WB Image
Rabbit Polyclonal to Human RAB7A / RAB7
Human
IHC, Western blot
Unconjugated
RAB7A / RAB7 Rabbit Polyclonal Unconjugated Human, Mouse, Rat, Bovine, Dog, Sheep WB No Primary
Anti-RAB7A / RAB7 Antibody LS-C83876
WB Image
Rabbit Polyclonal to Human RAB7A / RAB7
Human, Mouse, Rat, Bovine, Dog, Sheep
Western blot
Unconjugated
RAB7A / RAB7 Rabbit Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA N-Terminus No Primary
Anti-RAB7A / RAB7 Antibody (N-Terminus) LS-C47103
Rabbit Polyclonal to Human RAB7A / RAB7
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
RAB7A / RAB7 Rabbit IgG Polyclonal FITC Conjugated Human WB, ELISA C-Terminus No Primary
Anti-RAB7A / RAB7 Antibody (C-Terminus, FITC) LS-C220499
Rabbit Polyclonal (IgG) to Human RAB7A / RAB7
Human
Western blot, ELISA
FITC Conjugated
RAB7A / RAB7 Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human WB, ELISA C-Terminus No Primary
Anti-RAB7A / RAB7 Antibody (C-Terminus, Azide-free, HRP) LS-C220501
Rabbit Polyclonal (IgG) to Human RAB7A / RAB7
Human
Western blot, ELISA
HRP Conjugated, Azide-free
RAB7A / RAB7 Rabbit IgG Polyclonal PE Conjugated Human WB, ELISA C-Terminus No Primary
Anti-RAB7A / RAB7 Antibody (C-Terminus, PE) LS-C220502
Rabbit Polyclonal (IgG) to Human RAB7A / RAB7
Human
Western blot, ELISA
PE Conjugated
RAB7A / RAB7 Rabbit IgG Polyclonal APC Conjugated Human WB, ELISA C-Terminus No Primary
Anti-RAB7A / RAB7 Antibody (C-Terminus, APC) LS-C220496
Rabbit Polyclonal (IgG) to Human RAB7A / RAB7
Human
Western blot, ELISA
APC Conjugated
RAB7A / RAB7 Rabbit IgG Polyclonal AP Conjugated Human WB, ELISA C-Terminus No Primary
Anti-RAB7A / RAB7 Antibody (C-Terminus, AP) LS-C220497
Rabbit Polyclonal (IgG) to Human RAB7A / RAB7
Human
Western blot, ELISA
AP Conjugated
RAB7A / RAB7 Rabbit IgG Polyclonal Biotin Conjugated Human WB, ELISA C-Terminus No Primary
Anti-RAB7A / RAB7 Antibody (C-Terminus, Biotin) LS-C220498
Rabbit Polyclonal (IgG) to Human RAB7A / RAB7
Human
Western blot, ELISA
Biotin Conjugated
RAB7A / RAB7 Rabbit IgG Polyclonal Unconjugated Human, Mouse WB Asp193 No Primary
Anti-RAB7A / RAB7 Antibody (Asp193) LS-C75301
Rabbit Polyclonal (IgG) to Human RAB7A / RAB7
Human, Mouse
Western blot
Unconjugated

RAB7A / RAB7 Feature Table


Feature Type Location Details
Disease 1 - 207 Defects in RAB7A are the cause of Charcot-Marie-Tooth disease type 2B (CMT2B) [MIM:600882]; also known as hereditary motor and sensory neuropathy II (HMSN2). CMT2B is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2B is clinically characterized by marked distal muscle weakness and a high frequency of foot ulcers, infections and amputations of the toes. CMT2B
Function 1 - 207 Involved in late endocytic transport. Contributes to the maturation of phagosomes (acidification).
interaction 1 - 207 O60739:EIF1B; NbExp=1; IntAct=EBI-1056089, EBI-1043343; P40337:VHL; NbExp=1; IntAct=EBI-1056089, EBI-301246;
sequence caution 1 - 207 Sequence=BAA91390.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=BAF83410.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=EAW79303.1; Type=Erroneous gene model prediction;
Similarity 1 - 207 Belongs to the small GTPase superfamily. Rab family.
Subcellular Location 1 - 207 Late endosome. Lysosome. Cytoplasmic vesicle, phagosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Subunit 1 - 207 Interacts with RILP. Interacts with PSMA7. Interacts with RNF115.
Tissue Specificity 1 - 207 Widely expressed; high expression found in skeletal muscle.
web resource 1 - 207 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RAB7A";
web resource 1 - 207 Name=Inherited peripheral neuropathies mutation db; URL="http://www.molgen.ua.ac.be/CMTMutations/";
arrayexpress 1 - 207 P51149
bgee 1 - 207 P51149
cleanex 1 - 207 HS_RAB7A
ctd 1 - 207 7879
dip 1 - 207 DIP-39879N
doi 1 - 207 10
eggnog 1 - 207 prNOG16295
embl 1 - 207 AF050175
embl 1 - 207 AF498942
embl 1 - 207 AK000826
embl 1 - 207 AK290721
embl 1 - 207 BC008721
embl 1 - 207 CH471052
embl 1 - 207 U44104
embl 1 - 207 X93499
ensembl 1 - 207 ENST00000265062
ensembl 1 - 207 ENST00000430113
genecards 1 - 207 GC03P128444
geneid 1 - 207 7879
genevestigator 1 - 207 P51149
germonline 1 - 207 ENSG00000075785
go 1 - 207 GO:0003924
go 1 - 207 GO:0005515
go 1 - 207 GO:0005525
go 1 - 207 GO:0005764
go 1 - 207 GO:0005770
go 1 - 207 GO:0005794
go 1 - 207 GO:0006897
go 1 - 207 GO:0007264
go 1 - 207 GO:0015031
go 1 - 207 GO:0042470
go 1 - 207 GO:0045335
h-invdb 1 - 207 HIX0003657
hgnc 1 - 207 HGNC:9788
hogenom 1 - 207 HBG745225
hovergen 1 - 207 HBG009351
hpa 1 - 207 HPA006964
inparanoid 1 - 207 P51149
intact 1 - 207 P51149
interpro 1 - 207 IPR001806
interpro 1 - 207 IPR003579
interpro 1 - 207 IPR005225
interpro 1 - 207 IPR013753
interpro 1 - 207 IPR020851
ipi 1 - 207 IPI00016342
kegg 1 - 207 hsa:7879
medline 1 - 207 21099246
medline 1 - 207 97115674
medline 1 - 207 97271569
mim 1 - 207 600882
mim 1 - 207 602298
mint 1 - 207 MINT-4999676
nextbio 1 - 207 30336
oma 1 - 207 HRYVNDK
orphanet 1 - 207 64746
orphanet 1 - 207 99936
orthodb 1 - 207 EOG9KSS4C
pathway_interaction_db 1 - 207 il12_2pathway
pdb 1 - 207 1T91
pdb 1 - 207 1YHN
pdb 1 - 207 3LAW
pdbsum 1 - 207 1T91
pdbsum 1 - 207 1YHN
pdbsum 1 - 207 3LAW
peptideatlas 1 - 207 P51149
pfam 1 - 207 PF00071
phosphosite 1 - 207 P51149
phylomedb 1 - 207 P51149
pir 1 - 207 JC5268
pride 1 - 207 P51149
prints 1 - 207 PR00449
prosite 1 - 207 PS51419
proteinmodelportal 1 - 207 P51149
pubmed 1 - 207 11179213
pubmed 1 - 207 12545426
pubmed 1 - 207 12643545
pubmed 1 - 207 12944476
pubmed 1 - 207 14668488
pubmed 1 - 207 14702039
pubmed 1 - 207 14998988
pubmed 1 - 207 15455439
pubmed 1 - 207 15489334
pubmed 1 - 207 15592455
pubmed 1 - 207 15933719
pubmed 1 - 207 16925951
pubmed 1 - 207 17060578
pubmed 1 - 207 17081065
pubmed 1 - 207 17389395
pubmed 1 - 207 18669648
pubmed 1 - 207 19690332
pubmed 1 - 207 8954989
pubmed 1 - 207 9126495
refseq 1 - 207 NP_004628.4
smart 1 - 207 SM00175
string 1 - 207 P51149
tigrfams 1 - 207 TIGR00231
ucsc 1 - 207 uc003eks.1
unigene 1 - 207 Hs.15738
unigene 1 - 207 Hs.723832
alt_seq; genomic_dna 1 - 207 EAW79303.1
alt_seq; mrna 1 - 207 BAA91390.1
alt_seq; mrna 1 - 207 BAF83410.1
chain 1 - 207 Ras-related protein Rab-7a /FTId=PRO_0000121121.
conflict 47 - 47 T -> I (in Ref. 3; AAD02565)
conflict 108 - 108 I -> V (in Ref. 2; AAA86640)
conflict 127 - 127 I -> V (in Ref. 2; AAA86640)
conflict 180 - 180 V -> E (in Ref. 3; AAD02565)
lipid 205 - 205 S-geranylgeranyl cysteine (By similarity).
lipid 207 - 207 S-geranylgeranyl cysteine (By similarity).
Modification 72 - 72 Phosphoserine
Modification 183 - 183 Phosphotyrosine
Modification 207 - 207 Cysteine methyl ester (By similarity)
motif 37 - 45 Effector region (By similarity)
mutagen 8 - 8 L->A: Abolishes interaction with RAB7 and reduces its localization to late endosomal/lysosomal compartments.
mutagen 10 - 10 K->A: Abolishes interaction with RAB7 and localization to late endosomal/lysosomal compartments.
mutagen 22 - 22 T->N: Abolishes localization on late endosomes, lysosomes and phagosomes and reduces phagosomal fusions. Abolishes association of RILP with the phagosomes.
mutagen 67 - 67 Q->L: Does not abolish localization on late endosomes, lysosomes and phagosomes and does not reduce phagosomal fusions.
mutagen 180 - 180 V->A: Abolishes interaction with RAB7 and localization to late endosomal/lysosomal compartments.
mutagen 182 - 182 L->A: Does not abolish interaction with RAB7 and localization to late endosomal/lysosomal compartments. Does not abolish interaction with RAB7 and localization to late endosomal/lysosomal compartments; when associated with A-183.
mutagen 183 - 183 Y->A: Does not abolish interaction with RAB7 and localization to late endosomal/lysosomal compartments. Does not abolish interaction with RAB7 and localization to late endosomal/lysosomal compartments; when associated with A-182.
np_bind 15 - 22 GTP (By similarity)
np_bind 63 - 67 GTP (By similarity)
np_bind 125 - 128 GTP (By similarity)
variant 32 - 32 K -> E (in dbSNP:rs11549759) /FTId=VAR_037886.
variant 129 - 129 L -> F (in CMT2B) /FTId=VAR_018722.
variant 157 - 157 K -> N (in CMT2B) /FTId=VAR_037887.
variant 161 - 161 N -> T (in CMT2B) /FTId=VAR_037888.
variant 162 - 162 V -> M (in CMT2B) /FTId=VAR_018723.
keyword 1 - 207 3D-structure
keyword 1 - 207 Charcot-Marie-Tooth disease
keyword 1 - 207 Complete proteome
keyword 1 - 207 Cytoplasmic vesicle
keyword 1 - 207 Disease mutation
keyword 1 - 207 Endosome
keyword 1 - 207 GTP-binding
keyword 1 - 207 Lipoprotein
keyword 1 - 207 Lysosome
keyword 1 - 207 Methylation
keyword 1 - 207 Neuropathy
keyword 1 - 207 Nucleotide-binding
keyword 1 - 207 Phosphoprotein
keyword 1 - 207 Prenylation
keyword 1 - 207 Protein transport
keyword 1 - 207 Transport
Molecular Weight 1 - 207 23490
1 hit 1 - 207 PF00071
1 hit 1 - 207 PS51419

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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