PITX3

paired-like homeodomain 3

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle.

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Products

Antibodies (28)

Proteins (5)

Type

Over-Expression Lysate (2)

Primary (28)

Recombinant (3)

Target

PITX3 (33)

Reactivity

Human (28)

Mouse (18)

Rat (15)

Bat (11)

Bovine (8)

Chimpanzee (9)

Dog (11)

Gibbon (9)

Guinea pig (6)

Hamster (1)

Horse (11)

Monkey (12)

Pig (11)

Rabbit (11)

Sheep (8)

Zebrafish (3)

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Application

IHC (14)

IHC-P (9)

WB (23)

ELISA (6)

IF (1)

Peptide-ELISA (2)

Host

rabbit (26)

goat (1)

rabbit-new zealand white (1)

Product Group

IHCPlus (3)

Isotype

IgG (13)

Clonality

polyclonal pc (28)

Format

Biotin Conjugated (5)

FITC Conjugated (5)

HRP Conjugated (5)

Unconjugated (13)

Epitope

N-Terminus (13)

aa144-193 (4)

aa110-124 (1)

aa29-40 (1)

Publications

No (32)

Yes (1)

Tag

GST (1)

GST, N-terminus + His, C-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Mouse (2)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Yeast (1)

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PITX3 Antibody (N-Terminus) LS-B994

(4.0) Rating

(1) Publication(s)

Antibody:

PITX3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

PITX3 Antibody (N-Terminus, HRP) LS-C437161

Antibody:

PITX3 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PITX3 Antibody (N-Terminus, Biotin) LS-C437159

Antibody:

PITX3 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PITX3 Antibody (N-Terminus, FITC) LS-C437160

Antibody:

PITX3 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

IHC-plus™ PITX3 Antibody (N-Terminus) LS-B2606

(4.0) Rating

Antibody:

PITX3 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P

Format:

Unconjugated

Price:

25 µg/$485

Select

PITX3 Antibody (N-Terminus) LS-B6679

Antibody:

PITX3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

PITX3 Antibody (N-Terminus, HRP) LS-C428937

Antibody:

PITX3 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Zebrafish, Rat, Pig, Horse, Bat, Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Human, Monkey, Gibbon, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PITX3 Antibody (N-Terminus, Biotin) LS-C428935

Antibody:

PITX3 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Zebrafish, Rat, Pig, Horse, Bat, Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Human, Monkey, Gibbon, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PITX3 Antibody (N-Terminus, FITC) LS-C428936

Antibody:

PITX3 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Zebrafish, Rat, Pig, Horse, Bat, Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Human, Monkey, Gibbon, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PITX3 Antibody LS-C807371

Antibody:

PITX3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PITX3 Antibody (aa110-124) LS-C17509

Antibody:

PITX3 Rabbit anti-Human Polyclonal (aa110-124) Antibody

Reactivity:

Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Horse, Bat, Human, Monkey

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µg/$988

Select

PITX3 Antibody LS-C499069

Antibody:

PITX3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

PITX3 Antibody (HRP) LS-C499077

Antibody:

PITX3 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

PITX3 Antibody (Biotin) LS-C499104

Antibody:

PITX3 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

PITX3 Antibody (FITC) LS-C499072

Antibody:

PITX3 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PITX3 Antibody LS-C406157

Antibody:

PITX3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

PITX3 Antibody LS-C829303

Antibody:

PITX3 Rabbit-New Zealand White anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$393

Select

PITX3 Antibody LS-C779581

Antibody:

PITX3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PITX3 Antibody (aa29-40) LS-C55291

Antibody:

PITX3 Goat anti-Human Polyclonal (aa29-40) Antibody

Reactivity:

Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

PITX3 Antibody (aa144-193) LS-C101425

Antibody:

PITX3 Rabbit anti-Human Polyclonal (aa144-193) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

PITX3 Antibody (aa144-193, HRP) LS-C428873

Antibody:

PITX3 Rabbit anti-Human Polyclonal (aa144-193) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PITX3 Antibody (aa144-193, Biotin) LS-C428870

Antibody:

PITX3 Rabbit anti-Human Polyclonal (aa144-193) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PITX3 Antibody (aa144-193, FITC) LS-C428871

Antibody:

PITX3 Rabbit anti-Human Polyclonal (aa144-193) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PITX3 Antibody (N-Terminus) LS-C345696

Antibody:

PITX3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

PITX3 Antibody LS-C497278

Antibody:

PITX3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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