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Unfortunately, the antibody LS-C220279 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



PARK2 / Parkin Antibodies

parkin RBR E3 ubiquitin protein ligase

Gene Name: parkin RBR E3 ubiquitin protein ligase
Synonyms: PARK2 Antibody, AR-JP Antibody, LPRS2 Antibody, Parkin Antibody, PDJ Antibody, Parkinson disease protein 2 Antibody, PRKN Antibody
Target Sequences: NM_004562 NP_004553.2 O60260
 PARK2 / Parkin Feature Table
Featured Image

Featured PARK2 / Parkin Antibody

LS-B7045 is a rabbit polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.

Publications (1)

1
Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Bian M, Liu J, Hong X, Yu M, Huang Y, Sheng Z, Fei J, Huang F. PloS one. 2012 7:e39953. [PubMed:22792139] [PMC:PMC3390003] Related Antibodies: LS-C99184.

PARK2 / Parkin Antibodies (31)

Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-P, WB, ELISA aa1-50 No Primary
Anti-PARK2 / Parkin Antibody (aa1-50) IHC-plus™ LS-B7045
IHC Image
WB Image
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Mouse, Human, Orangutan, Rat IHC-P, WB aa311-360 No Primary
Anti-PARK2 / Parkin Antibody (aa311-360) IHC-plus™ LS-B5889
IHC Image
WB Image
Rabbit Polyclonal to Mouse PARK2 / Parkin
Mouse, Human, Orangutan, Rat
IHC - Paraffin, Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human IHC-P, IF, WB, Flo C-Terminus No Primary
Anti-PARK2 / Parkin Antibody (C-Terminus) LS-C99185
IHC Image
IHC Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human
IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human IHC-P, IF, WB, Flo N-Terminus Yes Primary
Anti-PARK2 / Parkin Antibody (N-Terminus) LS-C99184
PublicationsPublications (1)
IHC Image
IF Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human
IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC-P, WB, Flo, ELISA aa300-350 No Primary
Anti-PARK2 / Parkin Antibody (aa300-350) LS-C203086
Flo Image
WB Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Mouse, Rat
IHC - Paraffin, Western blot, Flow Cytometry, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human IHC-P, WB, ELISA aa101-150 No Primary
Anti-PARK2 / Parkin Antibody (aa101-150) LS-C117690
WB Image
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human IHC, ELISA pSer131 No Primary
Anti-PARK2 / Parkin Antibody (phospho-Ser131) LS-C199412
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
IHC, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Gibbon IHC, WB, ELISA aa62-80 No Primary
Anti-PARK2 / Parkin Antibody (aa62-80) LS-C40765
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Gibbon
IHC, Western blot, ELISA
Unconjugated
PARK2 / Parkin Goat IgG Polyclonal Unconjugated Human IHC-P, WB, ELISA aa83-97 No Primary
Anti-PARK2 / Parkin Antibody (aa83-97) LS-C27055
Goat Polyclonal (IgG) to Human PARK2 / Parkin
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
PARK2 / Parkin Mouse IgG1 Monoclonal 5A1 Unconjugated Human, Chimpanzee IHC, WB, IP No Primary
Anti-PARK2 / Parkin Antibody (clone 5A1) LS-C193601
Mouse Monoclonal [clone 5A1] (IgG1) to Human PARK2 / Parkin
Human, Chimpanzee
IHC, Western blot, Immunoprecipitation
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, ELISA aa300-350 No Primary
Anti-PARK2 / Parkin Antibody (aa300-350) LS-C93067
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Mouse, Rat
IHC, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, IP No Primary
Anti-PARK2 / Parkin Antibody LS-C74153
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Mouse, Rat
IHC, Western blot, Immunoprecipitation
Unconjugated
PARK2 / Parkin Mouse IgG1 Monoclonal Unconjugated Human, Mouse IHC, WB, ELISA No Primary
Anti-PARK2 / Parkin Antibody LS-C124347
Mouse Monoclonal (IgG1) to Human PARK2 / Parkin
Human, Mouse
IHC, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Orangutan, Monkey, Mouse, Rat, Bovine IHC, WB No Primary
Anti-PARK2 / Parkin Antibody LS-C93066
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Orangutan, Monkey, Mouse, Rat, Bovine
IHC, Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Orangutan, Monkey, Rat, Bovine IHC, WB No Primary
Anti-PARK2 / Parkin Antibody LS-C93065
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Orangutan, Monkey, Rat, Bovine
IHC, Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC N-Terminus No Primary
Anti-PARK2 / Parkin Antibody (N-Terminus) LS-C189151
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Mouse, Rat
IHC
Unconjugated
PARK2 / Parkin Mouse IgG3,k Monoclonal 1H4 Unconjugated Human IF, WB, ELISA No Primary
Anti-PARK2 / Parkin Antibody (clone 1H4) LS-C197846
IF Image
WB Image
Mouse Monoclonal [clone 1H4] (IgG3,k) to Human PARK2 / Parkin
Human
Immunofluorescence, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human WB Internal No Primary
Anti-PARK2 / Parkin Antibody (Internal) LS-C2827
WB Image
WB Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human
Western blot
Unconjugated
PARK2 / Parkin Goat Polyclonal Unconjugated Human WB, ELISA Internal No Primary
Anti-PARK2 / Parkin Antibody (Internal) LS-C55234
WB Image
Goat Polyclonal to Human PARK2 / Parkin
Human
Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human WB pSer378 No Primary
Anti-PARK2 / Parkin Antibody (phospho-Ser378) LS-C53475
WB Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human
Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Bovine WB pSer101 No Primary
Anti-PARK2 / Parkin Antibody (phospho-Ser101) LS-C53474
WB Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Bovine
Western blot
Unconjugated
PARK2 / Parkin Mouse IgG1 Monoclonal 1A1 Unconjugated Human, Chimpanzee, Mouse, Rat WB, IP No Primary
Anti-PARK2 / Parkin Antibody (clone 1A1) LS-C193600
Mouse Monoclonal [clone 1A1] (IgG1) to Human PARK2 / Parkin
Human, Chimpanzee, Mouse, Rat
Western blot, Immunoprecipitation
Unconjugated
PARK2 / Parkin Goat Polyclonal Unconjugated Human WB, ELISA aa83-97 No Primary
Anti-PARK2 / Parkin Antibody (aa83-97) LS-C85930
Goat Polyclonal to Human PARK2 / Parkin
Human
Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB C-Terminus No Primary
Anti-PARK2 / Parkin Antibody (C-Terminus) LS-C94428
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Mouse, Rat
Western blot
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human WB aa28-258 No Primary
Anti-PARK2 / Parkin Antibody (aa28-258) LS-C311769
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
Western blot
Unconjugated
PARK2 / Parkin Mouse Monoclonal PRK109 Unconjugated Human, Mouse, Rat IF, WB, IP, ELISA C-Terminus No Primary
Anti-PARK2 / Parkin Antibody (C-Terminus, clone PRK109) LS-C38090
Mouse Monoclonal [clone PRK109] to Human PARK2 / Parkin
Human, Mouse, Rat
Immunofluorescence, Western blot, Immunoprecipitation, ELISA
Unconjugated
PARK2 / Parkin Mouse IgG2a Monoclonal Unconjugated Human WB, ELISA aa1-437 No Primary
Anti-PARK2 / Parkin Antibody (aa1-437) LS-C38091
Mouse Monoclonal (IgG2a) to Human PARK2 / Parkin
Human
Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human WB, ELISA aa81-98 No Primary
Anti-PARK2 / Parkin Antibody (aa81-98) LS-C93069
Rabbit Polyclonal to Human PARK2 / Parkin
Human
Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human WB pSer101 No Primary
Anti-PARK2 / Parkin Antibody (phospho-Ser101) LS-C131307
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
Western blot
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human WB pSer378 No Primary
Anti-PARK2 / Parkin Antibody (phospho-Ser378) LS-C131306
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human WB Internal No Primary
Anti-PARK2 / Parkin Antibody (Internal) LS-C93062
Rabbit Polyclonal to Human PARK2 / Parkin
Human
Western blot
Unconjugated

PARK2 / Parkin Feature Table


Feature Type Location Details
alternative products 1 - 465 Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=O60260-1; Sequence=Displayed; Name=2; IsoId=O60260-2; Sequence=VSP_011707; Name=3; IsoId=O60260-3; Sequence=VSP_011706, VSP_011709, VSP_011710; Name=4; IsoId=O60260-4; Sequence=VSP_011705; Name=5; IsoId=O60260-5; Sequence=VSP_011708, VSP_011711, VSP_011712;
Disease 1 - 465 Defects in PARK2 are a cause of Parkinson disease (PARK) [MIM:168600]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early- onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial for
Disease 1 - 465 Defects in PARK2 are the cause of Parkinson disease type 2 (PARK2) [MIM:600116]; also known as early-onset parkinsonism with diurnal fluctuation (EPDF) or autosomal recessive juvenile Parkinson disease (PDJ). A neurodegenerative disorder characterized by bradykinesia, rigidity, postural instability, tremor, and onset usually befor 40. It differs from classic Parkinson disease by early DOPA-induced dyskinesia, diurnal fluctuation of the symptoms, sleep benefit, dystonia and hyper- reflexia. Dementia is absent. Pathologically, patients show loss of dopaminergic neurons in the substantia nigra, similar to that seen in Parkinson disease; however, Lewy bodies (intraneuronal accumulations of aggregated proteins) are absent.
Disease 1 - 465 Note=Defects in PARK2 may be involved in the development and/or progression of ovarian cancer.
domain 1 - 465 The ubiquitin-like domain binds the PSMD4 subunit of 26S proteasomes.
Function 1 - 465 Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5 and AIMP2. May play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Limits the production of reactive oxygen species (ROS). Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Regulates cyclin E during neuronal apoptosis. May
interaction 1 - 465 P49792:RANBP2; NbExp=6; IntAct=EBI-716346, EBI-973138; Q15645:TRIP13; NbExp=2; IntAct=EBI-716346, EBI-358993;
miscellaneous 1 - 465 The parkin locus (PRKN), adjacent to the 6q telomere is hyper-recombinable and lies within FRA6E, the third most common fragile site in tumor tissue.
pathway 1 - 465 Protein modification; protein ubiquitination.
ptm 1 - 465 Auto-ubiquitinates in an E2-dependent manner leading to its own degradation. Also polyubiquitinated by RNF41 for proteasomal degradation.
ptm 1 - 465 S-nitrosylated. The inhibition of PARK2 ubiquitin E3 ligase activity by S-nitrosylation could contribute to the degenerative process in PD by impairing the ubiquitination of PARK2 substrates.
Similarity 1 - 465 Belongs to the RBR family. Parkin subfamily.
Similarity 1 - 465 Contains 1 IBR-type zinc finger.
Similarity 1 - 465 Contains 1 ubiquitin-like domain.
Similarity 1 - 465 Contains 2 RING-type zinc fingers.
Subcellular Location 1 - 465 Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Co-localizes with SYT11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies.
Subunit 1 - 465 Forms an E3 ubiquitin ligase complex with UBE2L3 or UBE2L6. Part of a SCF-like complex, consisting of PARK2, CUL1 and FBXW7. Interacts with SNCAIP. Binds to the C2A and C2B domains of SYT11. Interacts and regulates the turnover of SEPT5. Part of a complex, including STUB1, HSP70 and GPR37. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2 and GPR37, thus facilitating PARK2-mediated GPR37 ubiquitination. HSP70 transiently associates with unfolded GPR37 and inhibits the E3 activity of PARK2, whereas, STUB1 enhances the E3 activity of PARK2 through promotion of dissociation of HSP70 from PARK2-GPR37 complexes. Interacts with PSMD4 and PACRG. Interacts with LRRK2. Interacts with RANBP2. Interacts with SUMO1 but not SUMO2, which promotes nuclear localization and autoubiquitination. Interacts (via first RING- type domai
Tissue Specificity 1 - 465 Highly expressed in the brain including the substantia nigra. Expressed in heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients. Overexpression protects dopamine neurons from kainate-mediated apoptosis. Found in serum (at protein level).
web resource 1 - 465 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PARK2";
arrayexpress 1 - 465 O60260
bgee 1 - 465 O60260
cleanex 1 - 465 HS_PARK2
ctd 1 - 465 5071
doi 1 - 465 10
embl 1 - 465 AB009973
embl 1 - 465 AF381282
embl 1 - 465 AF381283
embl 1 - 465 AF381286
embl 1 - 465 AK292590
embl 1 - 465 AL035697
embl 1 - 465 AL132982
embl 1 - 465 AL445215
embl 1 - 465 AP000886
embl 1 - 465 AP000887
embl 1 - 465 AP001576
embl 1 - 465 AP001577
embl 1 - 465 AP001578
embl 1 - 465 AP003699
embl 1 - 465 AY564225
embl 1 - 465 BC022014
embl 1 - 465 CH471051
embl 1 - 465 EF375726
ensembl 1 - 465 ENST00000366898
genecards 1 - 465 GC06M161740
geneid 1 - 465 5071
genevestigator 1 - 465 O60260
germonline 1 - 465 ENSG00000185345
go 1 - 465 GO:0000209
go 1 - 465 GO:0001933
go 1 - 465 GO:0004842
go 1 - 465 GO:0005634
go 1 - 465 GO:0005783
go 1 - 465 GO:0005794
go 1 - 465 GO:0005829
go 1 - 465 GO:0007417
go 1 - 465 GO:0008219
go 1 - 465 GO:0008270
go 1 - 465 GO:0016235
go 1 - 465 GO:0019900
go 1 - 465 GO:0030165
go 1 - 465 GO:0032232
go 1 - 465 GO:0042787
go 1 - 465 GO:0043123
go 1 - 465 GO:0048471
go 1 - 465 GO:0051087
go 1 - 465 GO:0051865
go 1 - 465 GO:0060548
go 1 - 465 GO:0070534
go 1 - 465 GO:0070842
go 1 - 465 GO:0080010
go 1 - 465 GO:0090201
hgnc 1 - 465 HGNC:8607
hovergen 1 - 465 HBG053682
hpa 1 - 465 CAB016257
inparanoid 1 - 465 O60260
intact 1 - 465 O60260
interpro 1 - 465 IPR000626
interpro 1 - 465 IPR002867
interpro 1 - 465 IPR003977
interpro 1 - 465 IPR016010
interpro 1 - 465 IPR019955
ipi 1 - 465 IPI00005254
ipi 1 - 465 IPI00332282
ipi 1 - 465 IPI00470427
ipi 1 - 465 IPI00470428
ipi 1 - 465 IPI00470429
kegg 1 - 465 hsa:5071
medline 1 - 465 20267489
medline 1 - 465 20347715
medline 1 - 465 20422559
medline 1 - 465 20542129
medline 1 - 465 20549560
medline 1 - 465 21090533
medline 1 - 465 21106127
medline 1 - 465 21332586
medline 1 - 465 21345366
medline 1 - 465 21380005
medline 1 - 465 21474644
medline 1 - 465 21966393
medline 1 - 465 22104975
medline 1 - 465 22108846
medline 1 - 465 22110646
medline 1 - 465 22146551
medline 1 - 465 22249643
medline 1 - 465 22284235
medline 1 - 465 22516579
medline 1 - 465 22516607
medline 1 - 465 22520692
medline 1 - 465 22615149
medline 1 - 465 22631680
medline 1 - 465 22667519
medline 1 - 465 22887331
medline 1 - 465 22935763
medline 1 - 465 22979425
medline 1 - 465 98219084
medline 1 - 465 98401162
medline 1 - 465 99172064
medline 1 - 465 99439450
mim 1 - 465 168600
mim 1 - 465 600116
mim 1 - 465 602544
mint 1 - 465 MINT-1351124
nextbio 1 - 465 19538
oma 1 - 465 CTDVRSP
orphanet 1 - 465 2828
orthodb 1 - 465 EOG96DPP1
panther 1 - 465 PTHR11685:SF2
pathway_interaction_db 1 - 465 alphasynuclein_pathway
pdb 1 - 465 1IYF
pdb 1 - 465 2JMO
pdbsum 1 - 465 1IYF
pdbsum 1 - 465 2JMO
pfam 1 - 465 PF00240
pfam 1 - 465 PF01485
pharmgkb 1 - 465 PA32942
phosphosite 1 - 465 O60260
phylomedb 1 - 465 O60260
pirsf 1 - 465 PIRSF037880
pride 1 - 465 O60260
prints 1 - 465 PR01475
prosite 1 - 465 PS00299
prosite 1 - 465 PS00518
prosite 1 - 465 PS50053
prosite 1 - 465 PS50089
proteinmodelportal 1 - 465 O60260
pubmed 1 - 465 10072423
pubmed 1 - 465 10319893
pubmed 1 - 465 10511432
pubmed 1 - 465 10824074
pubmed 1 - 465 10888878
pubmed 1 - 465 10939576
pubmed 1 - 465 10965160
pubmed 1 - 465 10973942
pubmed 1 - 465 11078524
pubmed 1 - 465 11163284
pubmed 1 - 465 11179010
pubmed 1 - 465 11431533
pubmed 1 - 465 11439185
pubmed 1 - 465 11487568
pubmed 1 - 465 11590439
pubmed 1 - 465 11971093
pubmed 1 - 465 12112109
pubmed 1 - 465 12114481
pubmed 1 - 465 12116199
pubmed 1 - 465 12150907
pubmed 1 - 465 12362318
pubmed 1 - 465 12397156
pubmed 1 - 465 12446796
pubmed 1 - 465 12628165
pubmed 1 - 465 12629236
pubmed 1 - 465 12634850
pubmed 1 - 465 12719539
pubmed 1 - 465 12730996
pubmed 1 - 465 12781599
pubmed 1 - 465 12925569
pubmed 1 - 465 14532270
pubmed 1 - 465 14574404
pubmed 1 - 465 14614460
pubmed 1 - 465 14702039
pubmed 1 - 465 14976155
pubmed 1 - 465 15105460
pubmed 1 - 465 15229644
pubmed 1 - 465 15489334
pubmed 1 - 465 15987638
pubmed 1 - 465 16135753
pubmed 1 - 465 16332688
pubmed 1 - 465 16352719
pubmed 1 - 465 16955485
pubmed 1 - 465 17360614
pubmed 1 - 465 18541373
pubmed 1 - 465 19501131
pubmed 1 - 465 9560156
pubmed 1 - 465 9731209
refseq 1 - 465 NP_004553.2
refseq 1 - 465 NP_054642.2
refseq 1 - 465 NP_054643.2
smart 1 - 465 SM00213
smart 1 - 465 SM00647
smr 1 - 465 O60260
string 1 - 465 O60260
ucsc 1 - 465 uc003qtx.2
ucsc 1 - 465 uc010kke.1
unigene 1 - 465 Hs.132954
joined; genomic_dna 1 - 465 CAH73681.1
joined; genomic_dna 1 - 465 CAI21385.1
joined; genomic_dna 1 - 465 CAI23601.1
chain 1 - 465 E3 ubiquitin-protein ligase parkin /FTId=PRO_0000058576.
conflict 223 - 223 S -> P (in Ref. 1; BAA25751 and 3; AAM21458/AAM21457).
conflict 289 - 290 CV -> MI (in Ref. 2; AAM21461)
conflict 339 - 339 A -> V (in Ref. 8; AAS88422)
domain 1 - 76 Ubiquitin-like
mutagen 332 - 332 C->S: Impairs folding of IBR domain
mutagen 337 - 337 C->A: Impairs the ability to ubiquitinate SNCAIP.
mutagen 365 - 365 C->S: Impairs protein folding
mutagen 418 - 418 C->R: Fails to ubiquitinate SYT11. Does not loose ability to bind SYT11.
mutagen 421 - 421 C->A: Impairs the ability of self- ubiquitination and to ubiquitinate SNCAIP.
mutagen 431 - 431 C->A: Impairs the ability to ubiquitinate SNCAIP.
region 204 - 238 SYT11 binding 1
region 257 - 293 SYT11 binding 2
var_seq 1 - 79 Missing (in isoform 3) /FTId=VSP_011706.
var_seq 1 - 191 Missing (in isoform 4) /FTId=VSP_011705.
var_seq 179 - 206 Missing (in isoform 2) /FTId=VSP_011707.
var_seq 290 - 290 V -> VGTGDTVVLRGALGGFRRGV (in isoform 5) /FTId=VSP_011708.
var_seq 291 - 297 AGCPNSL -> VCLLPGM (in isoform 3) /FTId=VSP_011709.
var_seq 298 - 465 Missing (in isoform 3) /FTId=VSP_011710.
var_seq 362 - 368 FAFCREC -> YGQRRTK (in isoform 5) /FTId=VSP_011711.
var_seq 369 - 465 Missing (in isoform 5) /FTId=VSP_011712.
variant 15 - 15 V -> M (in PARK) /FTId=VAR_019733.
variant 33 - 33 R -> Q (in PARK) /FTId=VAR_019734.
variant 37 - 37 P -> L (in PARK2) /FTId=VAR_019735.
variant 42 - 42 R -> P (in PARK; early-onset; induces a conformational change in the PSMD4- binding site of Ubl resulting in impaired proteasomal binding). /FTId=VAR_019736.
variant 46 - 46 A -> P (in PARK; early-onset; sporadic) /FTId=VAR_019737.
variant 82 - 82 A -> E (in PARK2 and PARK; dbSNP:rs55774500). /FTId=VAR_019738.
variant 92 - 92 A -> V (in PARK2) /FTId=VAR_019739.
variant 100 - 100 Q -> H /FTId=VAR_019740.
variant 161 - 161 K -> N (in PARK2 and PARK) /FTId=VAR_019741.
variant 167 - 167 S -> N (in dbSNP:rs1801474) /FTId=VAR_019742.
variant 192 - 192 M -> L (in dbSNP:rs9456735) /FTId=VAR_054107.
variant 192 - 192 M -> V (in PARK; early and late onset; dbSNP:rs9456735). /FTId=VAR_019743.
variant 211 - 211 K -> N (in PARK; early and late onset) /FTId=VAR_019744.
variant 211 - 211 K -> R (in PARK; early onset) /FTId=VAR_019745.
variant 212 - 212 C -> Y (in PARK2) /FTId=VAR_019746.
variant 240 - 240 T -> M (in PARK; late onset) /FTId=VAR_019747.
variant 240 - 240 T -> R (in PARK2; impairs the ability to ubiquitinate SNCAIP; loss of UBE2L3 binding). /FTId=VAR_019748.
variant 253 - 253 C -> Y (in PARK; late onset) /FTId=VAR_019749.
variant 256 - 256 R -> C (in PARK2 and PARK; early and late onset; impairs the ability to ubiquitinate SNCAIP; dbSNP:rs34424986). /FTId=VAR_019750.
variant 271 - 271 R -> S /FTId=VAR_019751.
variant 275 - 275 R -> W (in PARK2 and PARK; early and late onset; impairs the ability to ubiquitinate SNCAIP; dbSNP:rs34424986). /FTId=VAR_019752.
variant 280 - 280 D -> N (in PARK) /FTId=VAR_019753.
variant 284 - 284 G -> R (in PARK2) /FTId=VAR_019754.
variant 289 - 289 C -> G (in PARK; fails to ubiquitinate SYT11; loses ability to bind SYT11; dbSNP:rs55961220). /FTId=VAR_019755.
variant 311 - 311 Q -> R (in a patient with Parkinson disease; unknown pathological significance). /FTId=VAR_062672.
variant 328 - 328 G -> E (in PARK) /FTId=VAR_019756.
variant 334 - 334 R -> C (in PARK) /FTId=VAR_019757.
variant 339 - 339 A -> S /FTId=VAR_019758.
variant 351 - 351 T -> P (in PARK2; impairs folding of IBR domain). /FTId=VAR_019759.
variant 366 - 366 R -> W (in dbSNP:rs56092260) /FTId=VAR_019760.
variant 371 - 371 A -> T (in a patient with Parkinson disease; unknown pathological significance). /FTId=VAR_062673.
variant 380 - 380 V -> L (in dbSNP:rs1801582) /FTId=VAR_019761.
variant 394 - 394 D -> N (in dbSNP:rs1801334) /FTId=VAR_019762.
variant 415 - 415 T -> N (in PARK2 and PARK; impairs the ability to ubiquitinate SNCAIP; does not affect turnover of CDCRE1). /FTId=VAR_019763.
variant 430 - 430 G -> D (in PARK; early onset) /FTId=VAR_019764.
variant 431 - 431 C -> F (in PARK2) /FTId=VAR_019765.
variant 437 - 437 P -> L (in PARK; early and late onset) /FTId=VAR_019766.
variant 441 - 441 C -> R (in PARK) /FTId=VAR_019767.
zn_fing 238 - 293 RING-type 1; atypical
zn_fing 313 - 377 IBR-type
zn_fing 418 - 449 RING-type 2
keyword 1 - 465 3D-structure
keyword 1 - 465 Alternative splicing
keyword 1 - 465 Complete proteome
keyword 1 - 465 Cytoplasm
keyword 1 - 465 Disease mutation
keyword 1 - 465 Endoplasmic reticulum
keyword 1 - 465 Ligase
keyword 1 - 465 Metal-binding
keyword 1 - 465 Neurodegeneration
keyword 1 - 465 Nucleus
keyword 1 - 465 Parkinson disease
keyword 1 - 465 Parkinsonism
keyword 1 - 465 Polymorphism
keyword 1 - 465 Repeat
keyword 1 - 465 S-nitrosylation
keyword 1 - 465 Ubl conjugation
keyword 1 - 465 Ubl conjugation pathway
keyword 1 - 465 Zinc
keyword 1 - 465 Zinc-finger
Molecular Weight 1 - 465 51641
1 hit 1 - 465 PF00240
2 hits 1 - 465 PF01485
1 hit 1 - 465 PS50053
false_neg 1 - 465 PS00299
false_neg 1 - 465 PS00518
false_neg 1 - 465 PS50089

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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