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Unfortunately, the antibody LS-B5558 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



MSH6 Antibodies

mutS homolog 6

Gene Name: mutS homolog 6
Synonyms: MSH6 Antibody, GTBP Antibody, HSAP Antibody, GTMBP Antibody, MutS (E. coli) homolog 6 Antibody, HMSH6 Antibody, Sperm-associated protein Antibody, p160 Antibody, G/T mismatch-binding protein Antibody, HNPCC5 Antibody, MutS homolog 6 (E. coli) Antibody, MutS-alpha 160 kDa subunit Antibody
Target Sequences: NM_000179 NP_000170.1 P52701
 MSH6 Feature Table
Featured Image

Featured MSH6 Antibody

LS-B5106 is a goat polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.


MSH6 Antibodies (26)

Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
MSH6 Goat Polyclonal Unconjugated Human, Monkey, Mouse, Rat, Bat IHC-P aa2-14 No Primary
Anti-MSH6 Antibody (aa2-14) IHC-plus™ LS-B5106
IHC Image
IHC Image
Goat Polyclonal to Human MSH6
Human, Monkey, Mouse, Rat, Bat
IHC - Paraffin
Unconjugated
MSH6 Mouse IgG1 Monoclonal 5B11 Unconjugated Human IHC-P, WB, ELISA No Primary
Anti-MSH6 Antibody (clone 5B11) IHC-plus™ LS-B10739
IHC Image
WB Image
Mouse Monoclonal [clone 5B11] (IgG1) to Human MSH6
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
MSH6 Rabbit IgG Monoclonal SP93 Unconjugated Human IHC-P, WB Internal No Primary
Anti-MSH6 Antibody (Internal, clone SP93) LS-C210345
IHC Image
IHC Image
Rabbit Monoclonal [clone SP93] (IgG) to Human MSH6
Human
IHC - Paraffin, Western blot
Unconjugated
MSH6 Mouse IgG1 Monoclonal 3E1 Unconjugated Human IHC, ICC, IF, WB, Flo, ELISA No Primary
Anti-MSH6 Antibody (clone 3E1) LS-C169448
IHC Image
IHC Image
Mouse Monoclonal [clone 3E1] (IgG1) to Human MSH6
Human
IHC, ICC, Immunofluorescence, Western blot, Flow Cytometry, ELISA
Unconjugated
MSH6 Rabbit IgG Monoclonal EPR3945 Unconjugated Human, Mouse IHC-P, ICC, IF, WB, IP N-Terminus No Primary
Anti-MSH6 Antibody (N-Terminus, clone EPR3945) LS-C105752
IHC Image
IF Image
Rabbit Monoclonal [clone EPR3945] (IgG) to Human MSH6
Human, Mouse
IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated
MSH6 Goat IgG Polyclonal Unconjugated Human, Chimpanzee, Orangutan IHC-P, IF, WB, IP, PLA aa350-400 No
Anti-MSH6 Antibody (aa350-400) LS-C286964
IHC Image
WB Image
Goat Polyclonal (IgG) to Human MSH6
Human, Chimpanzee, Orangutan
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation, Proximity Ligation Assay
Unconjugated
MSH6 Rabbit Polyclonal Unconjugated Human, Mouse IHC, IF, WB Glu371 No Primary
Anti-MSH6 Antibody (Glu371) LS-C176981
IHC Image
WB Image
Rabbit Polyclonal to Human MSH6
Human, Mouse
IHC, Immunofluorescence, Western blot
Unconjugated
MSH6 Goat IgG Polyclonal Unconjugated Human IHC-P, IF aa350-400 No
Anti-MSH6 Antibody (aa350-400) LS-C286390
IHC Image
Goat Polyclonal (IgG) to Human MSH6
Human
IHC - Paraffin, Immunofluorescence
Unconjugated
MSH6 Rabbit Polyclonal Unconjugated Human IHC Internal No Primary
Anti-MSH6 Antibody (Internal) LS-C50530
IHC Image
Rabbit Polyclonal to Human MSH6
Human
IHC
Unconjugated
MSH6 Mouse IgG1,k Monoclonal SPM525 Unconjugated Human IHC-P Internal No Primary
Anti-MSH6 Antibody (Internal, clone SPM525) LS-C210528
IHC Image
Mouse Monoclonal [clone SPM525] (IgG1,k) to Human MSH6
Human
IHC - Paraffin
Unconjugated
MSH6 Mouse IgG1 Monoclonal Unconjugated Human, Mouse, Rat, Dog IHC-P No Primary
Anti-MSH6 Antibody LS-C72820
Mouse Monoclonal (IgG1) to Human MSH6
Human, Mouse, Rat, Dog
IHC - Paraffin
Unconjugated
MSH6 Mouse IgG1,k Monoclonal 1F2 Unconjugated Human IF, WB, ELISA No Primary
Anti-MSH6 Antibody (clone 1F2) LS-C197374
IF Image
WB Image
Mouse Monoclonal [clone 1F2] (IgG1,k) to Human MSH6
Human
Immunofluorescence, Western blot, ELISA
Unconjugated
MSH6 Rabbit IgG Polyclonal Unconjugated Human, Chimpanzee, Orangutan WB, IP, PLA C-Terminus No
Anti-MSH6 Antibody (C-Terminus) LS-C286965
WB Image
Rabbit Polyclonal (IgG) to Human MSH6
Human, Chimpanzee, Orangutan
Western blot, Immunoprecipitation, Proximity Ligation Assay
Unconjugated
MSH6 Mouse IgG1 Monoclonal 3A10H7 Unconjugated Human WB, ELISA No Primary
Anti-MSH6 Antibody (clone 3A10H7) LS-C109105
WB Image
Mouse Monoclonal [clone 3A10H7] (IgG1) to Human MSH6
Human
Western blot, ELISA
Unconjugated
MSH6 Goat Polyclonal Unconjugated Human WB, IP aa350-400 No Primary
Anti-MSH6 Antibody (aa350-400) LS-C56965
WB Image
Goat Polyclonal to Human MSH6
Human
Western blot, Immunoprecipitation
Unconjugated
MSH6 Rabbit IgG Polyclonal 15B Unconjugated Human, Mouse WB, ELISA Internal No Primary
Anti-MSH6 Antibody (Internal, clone 15B) LS-C191748
WB Image
Rabbit Polyclonal [clone 15B] (IgG) to Human MSH6
Human, Mouse
Western blot, ELISA
Unconjugated
MSH6 Rabbit IgG Polyclonal Unconjugated Human, Mouse WB, ELISA aa341-390 No Primary
Anti-MSH6 Antibody (aa341-390) LS-C119578
WB Image
Rabbit Polyclonal (IgG) to Human MSH6
Human, Mouse
Western blot, ELISA
Unconjugated
MSH6 Rabbit Polyclonal Unconjugated Human, Gibbon, Monkey, Mouse, Guinea pig WB aa251-300 No Primary
Anti-MSH6 Antibody (aa251-300) LS-C110632
WB Image
Rabbit Polyclonal to Human MSH6
Human, Gibbon, Monkey, Mouse, Guinea pig
Western blot
Unconjugated
MSH6 Mouse IgG1 Monoclonal Unconjugated Human WB, ELISA, GS No Primary
Anti-MSH6 Antibody LS-C43815
Mouse Monoclonal (IgG1) to Human MSH6
Human
Western blot, ELISA, Gel shift
Unconjugated
MSH6 Mouse IgG1 Monoclonal 44 Unconjugated Human, Mouse, Rat, Dog WB, IP No Primary
Anti-MSH6 Antibody (clone 44) LS-C95606
Mouse Monoclonal [clone 44] (IgG1) to Human MSH6
Human, Mouse, Rat, Dog
Western blot, Immunoprecipitation
Unconjugated
MSH6 Rabbit Polyclonal Unconjugated Human WB No Primary
Anti-MSH6 Antibody LS-C147004
Rabbit Polyclonal to Human MSH6
Human
Western blot
Unconjugated
MSH6 Goat Polyclonal Unconjugated Human ICC, WB, IP Internal No Primary
Anti-MSH6 Antibody (Internal) LS-C72817
Goat Polyclonal to Human MSH6
Human
ICC, Western blot, Immunoprecipitation
Unconjugated
MSH6 Rabbit IgG Monoclonal Unconjugated Human, Monkey IF, WB C-Terminus No Primary
Anti-MSH6 Antibody (C-Terminus) LS-C191051
Rabbit Monoclonal (IgG) to Human MSH6
Human, Monkey
Immunofluorescence, Western blot
Unconjugated
MSH6 Mouse IgG1 Monoclonal Unconjugated Human ELISA, GS No Primary
Anti-MSH6 Antibody LS-C9101
Mouse Monoclonal (IgG1) to Human MSH6
Human
ELISA, Gel shift
Unconjugated
MSH6 Rabbit Polyclonal Unconjugated Human WB, IP Internal No Primary
Anti-MSH6 Antibody (Internal) LS-C72818
Rabbit Polyclonal to Human MSH6
Human
Western blot, Immunoprecipitation
Unconjugated
MSH6 Rabbit Monoclonal DY488 Conjugated Human ICC N-Terminus No Primary
Anti-MSH6 Antibody (N-Terminus, DY488) LS-C130828
Rabbit Monoclonal to Human MSH6
Human
ICC
DY488 Conjugated

MSH6 Feature Table


Feature Type Location Details
alternative products 1 - 1360 Event=Alternative splicing; Named isoforms=2; Name=GTBP-N; IsoId=P52701-1; Sequence=Displayed; Name=GTBP-alt; IsoId=P52701-2; Sequence=VSP_003291, VSP_003292;
Disease 1 - 1360 Defects in MSH6 are a cause of susceptibility to endometrial cancer [MIM:608089].
Disease 1 - 1360 Defects in MSH6 are the cause of hereditary non-polyposis colorectal cancer type 5 (HNPCC5) [MIM:600678]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary
Function 1 - 1360 Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp
interaction 1 - 1360 P49662:CASP4; NbExp=1; IntAct=EBI-395529, EBI-1057327; P43246:MSH2; NbExp=1; IntAct=EBI-395529, EBI-355888; P01106:MYC; NbExp=1; IntAct=EBI-395529, EBI-447544;
ptm 1 - 1360 Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.
ptm 1 - 1360 Phosphorylated upon DNA damage, probably by ATM or ATR.
ptm 1 - 1360 The N-terminus is blocked.
Similarity 1 - 1360 Belongs to the DNA mismatch repair mutS family.
Similarity 1 - 1360 Contains 1 PWWP domain.
Subcellular Location 1 - 1360 Nucleus.
Subunit 1 - 1360 Heterodimer consisting of MSH2-MSH6 (MutS alpha). Forms a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ATR.
web resource 1 - 1360 Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MSH6ID344ch2p16.html";
web resource 1 - 1360 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MSH6";
web resource 1 - 1360 Name=Hereditary non-polyposis colorectal cancer db; URL="http://www.nfdht.nl/";
web resource 1 - 1360 Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/msh6/";
arrayexpress 1 - 1360 P52701
bgee 1 - 1360 P52701
cleanex 1 - 1360 HS_MSH6
ctd 1 - 1360 2956
doi 1 - 1360 10
eggnog 1 - 1360 prNOG13341
embl 1 - 1360 AY082894
embl 1 - 1360 BC004246
embl 1 - 1360 D89645
embl 1 - 1360 D89646
embl 1 - 1360 U28946
embl 1 - 1360 U54777
embl 1 - 1360 U73732
embl 1 - 1360 U73733
embl 1 - 1360 U73734
embl 1 - 1360 U73736
embl 1 - 1360 U73737
ensembl 1 - 1360 ENST00000234420
gene3d 1 - 1360 G3DSA:3.40.1170.10
genecards 1 - 1360 GC02P048010
geneid 1 - 1360 2956
genevestigator 1 - 1360 P52701
germonline 1 - 1360 ENSG00000116062
go 1 - 1360 GO:0000710
go 1 - 1360 GO:0005515
go 1 - 1360 GO:0005524
go 1 - 1360 GO:0008340
go 1 - 1360 GO:0008630
go 1 - 1360 GO:0009411
go 1 - 1360 GO:0016446
go 1 - 1360 GO:0032301
go 1 - 1360 GO:0045190
go 1 - 1360 GO:0045910
go 1 - 1360 GO:0051096
h-invdb 1 - 1360 HIX0002043
hgnc 1 - 1360 HGNC:7329
hogenom 1 - 1360 HBG633062
hovergen 1 - 1360 HBG000101
hpa 1 - 1360 CAB009091
hpa 1 - 1360 HPA028376
hpa 1 - 1360 HPA028446
inparanoid 1 - 1360 P52701
intact 1 - 1360 P52701
interpro 1 - 1360 IPR000313
interpro 1 - 1360 IPR000432
interpro 1 - 1360 IPR007695
interpro 1 - 1360 IPR007696
interpro 1 - 1360 IPR007860
interpro 1 - 1360 IPR007861
interpro 1 - 1360 IPR015536
interpro 1 - 1360 IPR016151
interpro 1 - 1360 IPR017261
ipi 1 - 1360 IPI00106847
ipi 1 - 1360 IPI00384456
kegg 1 - 1360 hsa:2956
medline 1 - 1360 20005667
medline 1 - 1360 20245492
medline 1 - 1360 21470348
medline 1 - 1360 21666030
medline 1 - 1360 95327933
medline 1 - 1360 95327934
medline 1 - 1360 95327935
medline 1 - 1360 96435440
medline 1 - 1360 97098445
medline 1 - 1360 98016406
medline 1 - 1360 98116665
medline 1 - 1360 99408236
medline 1 - 1360 99452590
mim 1 - 1360 600678
mim 1 - 1360 608089
mint 1 - 1360 MINT-131993
nextbio 1 - 1360 11716
oma 1 - 1360 MAHISKY
orphanet 1 - 1360 144
orthodb 1 - 1360 EOG9KSS4D
panther 1 - 1360 PTHR11361
panther 1 - 1360 PTHR11361:SF31
pdb 1 - 1360 2GFU
pdb 1 - 1360 2O8B
pdb 1 - 1360 2O8C
pdb 1 - 1360 2O8D
pdb 1 - 1360 2O8E
pdb 1 - 1360 2O8F
pdbsum 1 - 1360 2GFU
pdbsum 1 - 1360 2O8B
pdbsum 1 - 1360 2O8C
pdbsum 1 - 1360 2O8D
pdbsum 1 - 1360 2O8E
pdbsum 1 - 1360 2O8F
peptideatlas 1 - 1360 P52701
pfam 1 - 1360 PF00488
pfam 1 - 1360 PF00855
pfam 1 - 1360 PF01624
pfam 1 - 1360 PF05188
pfam 1 - 1360 PF05190
pfam 1 - 1360 PF05192
pharmgkb 1 - 1360 PA184
phosphosite 1 - 1360 P52701
phylomedb 1 - 1360 P52701
pir 1 - 1360 JC5839
pirsf 1 - 1360 PIRSF037677
pmap-cutdb 1 - 1360 P52701
pride 1 - 1360 P52701
prosite 1 - 1360 PS00486
prosite 1 - 1360 PS50812
proteinmodelportal 1 - 1360 P52701
pubmed 1 - 1360 10078208
pubmed 1 - 1360 10413423
pubmed 1 - 1360 10480359
pubmed 1 - 1360 10521294
pubmed 1 - 1360 10537275
pubmed 1 - 1360 10660545
pubmed 1 - 1360 10699937
pubmed 1 - 1360 10783165
pubmed 1 - 1360 11153917
pubmed 1 - 1360 11470537
pubmed 1 - 1360 11586295
pubmed 1 - 1360 11709755
pubmed 1 - 1360 11807791
pubmed 1 - 1360 12522549
pubmed 1 - 1360 12658575
pubmed 1 - 1360 14520694
pubmed 1 - 1360 14961575
pubmed 1 - 1360 14974087
pubmed 1 - 1360 15064730
pubmed 1 - 1360 15302935
pubmed 1 - 1360 15354210
pubmed 1 - 1360 15365995
pubmed 1 - 1360 15483016
pubmed 1 - 1360 15489334
pubmed 1 - 1360 15808853
pubmed 1 - 1360 16565220
pubmed 1 - 1360 16964243
pubmed 1 - 1360 17081983
pubmed 1 - 1360 17344846
pubmed 1 - 1360 17525332
pubmed 1 - 1360 17531815
pubmed 1 - 1360 17924679
pubmed 1 - 1360 18033691
pubmed 1 - 1360 18220336
pubmed 1 - 1360 18669648
pubmed 1 - 1360 18691976
pubmed 1 - 1360 19608861
pubmed 1 - 1360 7604264
pubmed 1 - 1360 7604265
pubmed 1 - 1360 7604266
pubmed 1 - 1360 8838326
pubmed 1 - 1360 8942985
pubmed 1 - 1360 9354786
pubmed 1 - 1360 9455487
pubmed 1 - 1360 9564049
pubmed 1 - 1360 9822679
pubmed 1 - 1360 9822680
pubmed 1 - 1360 9889267
refseq 1 - 1360 NP_000170.1
smart 1 - 1360 SM00293
smart 1 - 1360 SM00533
smart 1 - 1360 SM00534
string 1 - 1360 P52701
supfam 1 - 1360 SSF48334
supfam 1 - 1360 SSF53150
supfam 1 - 1360 SSF55271
ucsc 1 - 1360 uc002rwc.2
ucsc 1 - 1360 uc002rwd.2
unigene 1 - 1360 Hs.445052
joined; genomic_dna 1 - 1360 AAB47425.1
chain 1 - 1360 DNA mismatch repair protein Msh6 /FTId=PRO_0000115207.
compbias 34 - 37 Poly-Ala
compbias 201 - 209 Poly-Glu
compbias 1118 - 1123 Poly-Glu
conflict 36 - 57 AAPGASPSPGGDAAWSEAGPGP -> GCPRGLSFPRRGCGL ERGWAWA (in Ref. 2; BAA23674/BAA23675).
conflict 1358 - 1360 KEL -> D (in Ref. 3; AAL87401)
domain 92 - 154 PWWP
Modification 14 - 14 Phosphoserine
Modification 41 - 41 Phosphoserine
Modification 43 - 43 Phosphoserine
Modification 70 - 70 N6-acetyllysine
Modification 79 - 79 Phosphoserine
Modification 91 - 91 Phosphoserine
Modification 137 - 137 Phosphoserine
Modification 139 - 139 Phosphothreonine
Modification 200 - 200 Phosphoserine
Modification 219 - 219 Phosphoserine
Modification 227 - 227 Phosphoserine
Modification 252 - 252 Phosphoserine
Modification 254 - 254 Phosphoserine
Modification 256 - 256 Phosphoserine
Modification 261 - 261 Phosphoserine
Modification 309 - 309 Phosphoserine
Modification 348 - 348 Phosphoserine
Modification 504 - 504 N6-acetyllysine
Modification 830 - 830 Phosphoserine
Modification 924 - 924 Phosphothreonine
mutagen 1140 - 1140 K->R: No effect on mismatch binding, complete loss of DNA repair function when associated with MSH2 mutant R-675.
np_bind 1134 - 1141 ATP (Potential)
var_seq 1058 - 1068 DVLLCLANYSR -> GKTLNKLVLRL (in isoform GTBP-alt). /FTId=VSP_003291.
var_seq 1069 - 1360 Missing (in isoform GTBP-alt) /FTId=VSP_003292.
variant 13 - 13 K -> T (in dbSNP:rs41294988) /FTId=VAR_038032.
variant 20 - 20 A -> V (in colorectal/endometrial cancer). /FTId=VAR_043943.
variant 25 - 25 A -> V (in dbSNP:rs35462442) /FTId=VAR_038033.
variant 39 - 39 G -> E (in dbSNP:rs1042821) /FTId=VAR_004490.
variant 54 - 54 G -> A (in CRC; uncertain pathogenicity) /FTId=VAR_043944.
variant 65 - 65 S -> L (in dbSNP:rs41294984) /FTId=VAR_038034.
variant 99 - 99 K -> N (in CRC; uncertain pathogenicity) /FTId=VAR_043945.
variant 128 - 128 R -> L (no impairment of heterodimerization with MSH2 and of in vitro mismatch repair capacity). /FTId=VAR_043946.
variant 144 - 144 S -> I (in suspected HNPCC5 and CRC; dbSNP:rs3211299). /FTId=VAR_012955.
variant 220 - 220 E -> D (in dbSNP:rs1800938) /FTId=VAR_012956.
variant 221 - 221 E -> D (in dbSNP:rs41557217) /FTId=VAR_042274.
variant 285 - 285 S -> I (in CRC) /FTId=VAR_012957.
variant 295 - 295 K -> R (in multiple colorectal adenoma) /FTId=VAR_043947.
variant 340 - 340 F -> S (in CRC, breast cancer and leukemia). /FTId=VAR_043948.
variant 396 - 396 L -> V (rare polymorphism; dbSNP:rs2020908). /FTId=VAR_012958.
variant 449 - 449 L -> P (in colorectal/endometrial cancer; uncertain pathogenicity). /FTId=VAR_043949.
variant 468 - 468 R -> H (in dbSNP:rs41295268) /FTId=VAR_038035.
variant 492 - 492 M -> V (in HNPCC5) /FTId=VAR_042275.
variant 503 - 503 S -> C /FTId=VAR_038036.
variant 509 - 509 V -> A /FTId=VAR_043950.
variant 522 - 522 Q -> R (in CRC; uncertain pathogenicity) /FTId=VAR_043951.
variant 538 - 538 Y -> S (in dbSNP:rs728619) /FTId=VAR_038037.
variant 566 - 566 G -> R (in CRC; partial functional loss) /FTId=VAR_012959.
variant 580 - 580 S -> L (in dbSNP:rs41295270) /FTId=VAR_038038.
variant 619 - 619 E -> D (in CRC; uncertain pathogenicity) /FTId=VAR_043952.
variant 623 - 623 P -> A (in dbSNP:rs3136334) /FTId=VAR_029244.
variant 623 - 623 P -> L (no impairment of heterodimerization with MSH2 and of in vitro mismatch repair capacity). /FTId=VAR_043953.
variant 685 - 685 G -> A (in CRC) /FTId=VAR_043954.
variant 698 - 698 Q -> E (in suspected HNPCC; could be a polymorphism). /FTId=VAR_012960.
variant 725 - 725 I -> M (in CRC; uncertain pathogenicity) /FTId=VAR_043955.
variant 728 - 728 K -> T (no impairment of heterodimerization with MSH2 and of in vitro mismatch repair capacity; dbSNP:rs35552856). /FTId=VAR_043956.
variant 772 - 772 R -> Q (in CRC) /FTId=VAR_043957.
variant 772 - 772 R -> W (in HNPCC5) /FTId=VAR_043958.
variant 787 - 787 A -> V (in CRC; uncertain pathogenicity) /FTId=VAR_043959.
variant 800 - 800 V -> A (in CRC; somatic mutation) /FTId=VAR_043960.
variant 800 - 800 V -> L (may be a rare polymorphism) /FTId=VAR_012961.
variant 803 - 803 D -> G (in CRC) /FTId=VAR_012962.
variant 850 - 850 Y -> C (in suspected HNPCC5 and CRC) /FTId=VAR_012963.
variant 854 - 854 K -> M (in CRC; could be a polymorphism; dbSNP:rs34374438). /FTId=VAR_043961.
variant 878 - 878 V -> A (in suspected HNPCC5, colorectal/ endometrial cancer and CRC; dbSNP:rs2020912). /FTId=VAR_012964.
variant 886 - 886 I -> V (in dbSNP:rs2020914) /FTId=VAR_014902.
variant 901 - 901 R -> H (in colorectal/endometrial cancer). /FTId=VAR_043962.
variant 976 - 976 R -> H (in CRC; sporadic) /FTId=VAR_012965.
variant 1021 - 1021 A -> D (in CRC; uncertain pathogenicity) /FTId=VAR_043963.
variant 1031 - 1031 D -> V (in CRC; somatic mutation) /FTId=VAR_043964.
variant 1076 - 1076 R -> C (in CRC; uncertain pathogenicity) /FTId=VAR_043965.
variant 1087 - 1087 P -> T (in CRC) /FTId=VAR_012966.
variant 1095 - 1095 R -> H (in CRC; uncertain pathogenicity) /FTId=VAR_043966.
variant 1100 - 1100 T -> M (in CRC; uncertain pathogenicity) /FTId=VAR_043967.
variant 1158 - 1158 C -> R (in CRC; somatic mutation) /FTId=VAR_043968.
variant 1163 - 1163 E -> V (in HNPCC5) /FTId=VAR_043969.
variant 1193 - 1193 E -> K (in endometrial cancer; display marked impairment of heterodimerization with MSH2 and of in vitro mismatch repair capacity). /FTId=VAR_043970.
variant 1213 - 1213 D -> V /FTId=VAR_004491.
variant 1219 - 1219 T -> I (in CRC; uncertain pathogenicity) /FTId=VAR_043971.
variant 1232 - 1232 V -> L (in dbSNP:rs41295276) /FTId=VAR_038039.
variant 1234 - 1234 E -> Q (in dbSNP:rs35717727) /FTId=VAR_038040.
variant 1248 - 1248 H -> D (in CRC; uncertain pathogenicity) /FTId=VAR_043972.
variant 1260 - 1260 V -> I /FTId=VAR_004492.
variant 1284 - 1284 T -> M (in CRC) /FTId=VAR_043973.
variant 1321 - 1321 R -> G (in dbSNP:rs41295278) /FTId=VAR_038041.
variant 1354 - 1354 L -> Q (in CRC; uncertain pathogenicity) /FTId=VAR_043974.
keyword 1 - 1360 3D-structure
keyword 1 - 1360 Acetylation
keyword 1 - 1360 Alternative splicing
keyword 1 - 1360 ATP-binding
keyword 1 - 1360 Complete proteome
keyword 1 - 1360 Direct protein sequencing
keyword 1 - 1360 Disease mutation
keyword 1 - 1360 DNA damage
keyword 1 - 1360 DNA repair
keyword 1 - 1360 DNA-binding
keyword 1 - 1360 Hereditary nonpolyposis colorectal cancer
keyword 1 - 1360 Nucleotide-binding
keyword 1 - 1360 Nucleus
keyword 1 - 1360 Phosphoprotein
keyword 1 - 1360 Polymorphism
Molecular Weight 1 - 1360 152786
1 hit 1 - 1360 PF00488
1 hit 1 - 1360 PF00855
1 hit 1 - 1360 PF01624
1 hit 1 - 1360 PF05188
1 hit 1 - 1360 PF05190
1 hit 1 - 1360 PF05192
1 hit 1 - 1360 PS00486
1 hit 1 - 1360 PS50812

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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