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Unfortunately, the antibody LS-C219777 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



IKBKG / NEMO / IKK Gamma Antibodies

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. The IkB kinase (IKKa and IKKb) phosphorylates IkB and mediates NF-kB activation. A novel molecule in the IKK complex was recently identified and termed IKKg/NEMO/FIP3/IKKAP1. IKKg interacts with IKKb and is required for the activation of IKK complex and NF-kB by LPS, PMA, TNF, and IL-1 stimulation. FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-kB activation.

Gene Name: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Family/Subfamily: Protein Kinase Non Catalytic , IKAPPAB
Synonyms: IKBKG Antibody, AMCBX1 Antibody, FIP3 Antibody, Fip3p Antibody, IkappaB kinase gamma Antibody, IKKgamma Antibody, IKK-gamma Antibody, NEMO Antibody, NF-kappa-B essential modifier Antibody, I-kappa-B kinase gamma-subunit Antibody, I-kappa-B kinase subunit gamma Antibody, IkB kinase gamma subunit Antibody, IKKAP1 Antibody, Incontinentia pigmenti Antibody, IP2 Antibody, IPD2 Antibody, NF-kappa-B essential modulator Antibody, ZC2HC9 Antibody, FIP-3 Antibody, IkB kinase subunit gamma Antibody, IKKG Antibody, IP1 Antibody, NFkappaB essential modulator Antibody
Target Sequences: NM_003639 NP_003630.1 Q9Y6K9
 IKBKG / NEMO / IKK Gamma Feature Table
Featured Image

Featured IKBKG / NEMO / IKK Gamma Antibody

LS-B4878 is a mouse monoclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.


IKBKG / NEMO / IKK Gamma Antibodies (48)

Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal 46B844 Unconjugated Human IHC-P, WB, Flo No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 46B844) IHC-plus™ LS-B4878
IHC Image
IHC Image
Mouse Monoclonal [clone 46B844] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
IHC - Paraffin, Western blot, Flow Cytometry
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human IHC-P, IF, WB, ELISA aa51-100 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa51-100) IHC-plus™ LS-B11163
IHC Image
WB Image
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC-P, ICC, WB aa400-416 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa400-416) IHC-plus™ LS-B1363
IHC Image
ICC Image
Rabbit Polyclonal to Human IKBKG / NEMO / IKK Gamma
Human, Mouse, Rat
IHC - Paraffin, ICC, Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human, Gorilla IHC-P, WB, ELISA aa2-13 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa2-13) IHC-plus™ LS-B1725
IHC Image
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human, Gorilla
IHC - Paraffin, Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human, Gorilla, Monkey, Mouse, Rat, Dog, Hamster, Horse, Rabbit IHC-P, WB, ELISA aa385-399 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa385-399) IHC-plus™ LS-B1724
IHC Image
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human, Gorilla, Monkey, Mouse, Rat, Dog, Hamster, Horse, Rabbit
IHC - Paraffin, Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit Polyclonal Unconjugated Human IHC-P, WB N-Terminus No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (N-Terminus) IHC-plus™ LS-B1738
IHC Image
Rabbit Polyclonal
Human
IHC - Paraffin, Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human IHC, WB, ELISA pSer31 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (phospho-Ser31) LS-C199106
WB Image
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
IHC, Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit Polyclonal Unconjugated Human IHC, IF, WB His81 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (His81) LS-C176678
IHC Image
WB Image
Rabbit Polyclonal to Human IKBKG / NEMO / IKK Gamma
Human
IHC, Immunofluorescence, Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human IHC-P, WB, ELISA aa16-65 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa16-65) LS-C117619
WB Image
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit Polyclonal Unconjugated Human IHC, WB Asp25 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (Asp25) LS-C176655
IHC Image
WB Image
Rabbit Polyclonal to Human IKBKG / NEMO / IKK Gamma
Human
IHC, Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human IHC, ELISA pSer376 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (phospho-Ser376) LS-C199107
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
IHC, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1,k Monoclonal 4G9 Unconjugated Human IF, WB, ELISA No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 4G9) LS-C133550
IHC Image
IF Image
Mouse Monoclonal [clone 4G9] (IgG1,k) to Human IKBKG / NEMO / IKK Gamma
Human
Immunofluorescence, Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal EA2-6 Unconjugated Human, Mouse, Rat IHC-P, WB, IP No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone EA2-6) LS-C179688
Mouse Monoclonal [clone EA2-6] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human, Mouse, Rat
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit Polyclonal Unconjugated Human IHC, IF, WB Ala314 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (Ala314) LS-C176956
WB Image
Rabbit Polyclonal to Human IKBKG / NEMO / IKK Gamma
Human
IHC, Immunofluorescence, Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human IHC-P, WB aa701-716 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa701-716) LS-C187757
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
IHC - Paraffin, Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal Unconjugated, Azide-free Human IHC-P, IF, WB, ELISA aa1-420 No
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa1-420, Azide-free) LS-C327607
Mouse Monoclonal (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Unconjugated, Azide-free
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human, Monkey, Mouse, Rat IHC-P, WB, ELISA C-Terminus No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (C-Terminus) LS-C15929
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human, Monkey, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human WB, ELISA pSer85 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (phospho-Ser85) LS-C199108
WB Image
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa291-340 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa291-340) LS-C119356
WB Image
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal 55AT986.5.78 Unconjugated Human WB No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 55AT986.5.78) LS-C96497
WB Image
Mouse Monoclonal [clone 55AT986.5.78] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit Polyclonal Unconjugated Human WB C-Terminus No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (C-Terminus) LS-C2792
Rabbit Polyclonal to Human IKBKG / NEMO / IKK Gamma
Human
Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human, Chimpanzee, Mouse, Rat, Bat, Dog, Guinea pig, Horse, Pig, Rabbit WB aa150-199 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa150-199) LS-C30997
WB Image
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human, Chimpanzee, Mouse, Rat, Bat, Dog, Guinea pig, Horse, Pig, Rabbit
Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal 72C627 Unconjugated Human, Mouse WB No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 72C627) LS-C557
WB Image
Mouse Monoclonal [clone 72C627] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human, Mouse
Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human WB No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody LS-C137397
WB Image
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit Polyclonal Unconjugated Human, Chimpanzee, Gibbon, Monkey, Mouse, Guinea pig, Rabbit WB N-Terminus No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (N-Terminus) LS-C109548
WB Image
Rabbit Polyclonal to Human IKBKG / NEMO / IKK Gamma
Human, Chimpanzee, Gibbon, Monkey, Mouse, Guinea pig, Rabbit
Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Mouse WB aa1-15 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa1-15) LS-C312712
WB Image
Rabbit Polyclonal (IgG) to Mouse IKBKG / NEMO / IKK Gamma
Mouse
Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit Polyclonal Unconjugated Human WB aa1-30 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa1-30) LS-C159896
WB Image
Rabbit Polyclonal to Human IKBKG / NEMO / IKK Gamma
Human
Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal DA10-12 Unconjugated Human WB No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone DA10-12) LS-C179687
WB Image
Mouse Monoclonal [clone DA10-12] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1,k Monoclonal 72C627 Unconjugated Human, Mouse ELISA No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 72C627) LS-C148148
Mouse Monoclonal [clone 72C627] (IgG1,k) to Human IKBKG / NEMO / IKK Gamma
Human, Mouse
ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal FITC Conjugated Human WB, ELISA aa1-30 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa1-30, FITC) LS-C215237
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
FITC Conjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Biotin Conjugated Human WB, ELISA aa1-30 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa1-30, Biotin) LS-C215236
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
Biotin Conjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal APC Conjugated Human WB, ELISA aa1-30 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa1-30, APC) LS-C215235
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
APC Conjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human WB, ELISA aa1-30 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa1-30, Azide-free, HRP) LS-C215238
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
HRP Conjugated, Azide-free
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal 55AT986.5.78 Unconjugated Human WB, ELISA No
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 55AT986.5.78) LS-C329164
Mouse Monoclonal [clone 55AT986.5.78] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal Unconjugated Human, Mouse WB, ELISA No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody LS-C15918
Mouse Monoclonal (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human, Mouse
Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal PE Conjugated Human WB, ELISA aa1-30 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa1-30, PE) LS-C215243
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
PE Conjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal AP Conjugated Human WB, ELISA aa1-30 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa1-30, AP) LS-C215234
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
AP Conjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal 55AT986.5.78 APC Conjugated Human WB, ELISA No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 55AT986.5.78, APC) LS-C212467
Mouse Monoclonal [clone 55AT986.5.78] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
APC Conjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal 55AT986.5.78 AP Conjugated Human WB, ELISA No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 55AT986.5.78, AP) LS-C212466
Mouse Monoclonal [clone 55AT986.5.78] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
AP Conjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa1-30 No
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa1-30) LS-C322185
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal 55AT986.5.78 Biotin Conjugated Human WB, ELISA No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 55AT986.5.78, Biotin) LS-C212468
Mouse Monoclonal [clone 55AT986.5.78] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
Biotin Conjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal 55AT986.5.78 PE Conjugated Human WB, ELISA No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 55AT986.5.78, PE) LS-C212472
Mouse Monoclonal [clone 55AT986.5.78] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
PE Conjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal 55AT986.5.78 HRP Conjugated, Azide-free Human WB, ELISA No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 55AT986.5.78, Azide-free, HRP) LS-C212470
Mouse Monoclonal [clone 55AT986.5.78] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
HRP Conjugated, Azide-free
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal 55AT986.5.78 FITC Conjugated Human WB, ELISA No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (clone 55AT986.5.78, FITC) LS-C212469
Mouse Monoclonal [clone 55AT986.5.78] (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot, ELISA
FITC Conjugated
IKBKG / NEMO / IKK Gamma Rabbit IgG Polyclonal Unconjugated Human, Gorilla, Monkey, Mouse, Rat, Bat, Dog, Hamster, Horse, Pig, Rabbit WB aa400-416 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (aa400-416) LS-C125747
Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma
Human, Gorilla, Monkey, Mouse, Rat, Bat, Dog, Hamster, Horse, Pig, Rabbit
Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Rabbit Polyclonal Unconjugated Human ELISA pSer31 No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody (phospho-Ser31) LS-C125748
Rabbit Polyclonal to Human IKBKG / NEMO / IKK Gamma
Human
ELISA
Unconjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal Unconjugated Human WB No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody LS-C15921
Mouse Monoclonal (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human
Western blot
Unconjugated
IKBKG / NEMO / IKK Gamma Mouse IgG1 Monoclonal Unconjugated Human, Mouse WB No Primary
Anti-IKBKG / NEMO / IKK Gamma Antibody LS-C70501
Mouse Monoclonal (IgG1) to Human IKBKG / NEMO / IKK Gamma
Human, Mouse
Western blot
Unconjugated

IKBKG / NEMO / IKK Gamma Feature Table


Feature Type Location Details
Disease 1 - 419 Defects in IKBKG are a cause of immunodeficiency NEMO- related without anhidrotic ectodermal dysplasia (NEMOID) [MIM:300584]; also called immunodeficiency without anhidrotic ectodermal dysplasia, isolated immunodeficiency or pure immunodeficiency. Patients manifest immunodeficiency not associated with other abnormalities, and resulting in increased infection susceptibility. Patients suffer from multiple episodes of infectious diseases.
Disease 1 - 419 Defects in IKBKG are the cause of ectodermal dysplasia anhidrotic with immunodeficiency X-linked (EDAID) [MIM:300291]; also known as hypohidrotic ectodermal dysplasia with immunodeficiency (HED-ID). Is a form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by absence of sweat glands, sparse scalp hair, rare conical teeth and immunological abnormalities resulting in severe infectious diseases.
Disease 1 - 419 Defects in IKBKG are the cause of ectodermal dysplasia anhidrotic with immunodeficiency-osteopetrosis-lymphedema (OLEDAID) [MIM:300301].
Disease 1 - 419 Defects in IKBKG are the cause of incontinentia pigmenti (IP) [MIM:308300]; formerly designed familial incontinentia pigmenti type II (IP2). IP is a genodermatosis usually prenatally lethal in males. In affected females, it causes abnormalities of the skin, hair, eyes, nails, teeth, skeleton, heart, and central nervous system. The prominent skin signs occur in four classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation and dermal scarring.
Disease 1 - 419 Defects in IKBKG are the cause of recurrent isolated invasive pneumococcal disease type 2 (IPD2) [MIM:300640]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.
Disease 1 - 419 Defects in IKBKG are the cause of susceptibility to X- linked familial atypical micobacteriosis type 1 (AMCBX1) [MIM:300636]; also known as X-linked disseminated atypical mycobacterial infection type 1 or X-linked susceptibility to mycobacterial disease type 1. AMCBX1 is the X-linked recessive form of mendelian susceptibility to mycobacterial disease (MSMD). MSMD is a congenital syndrome resulting in predisposition to clinical disease caused by weakly virulent mycobacterial species, such as bacillus Calmette-Guerin vaccines and non-tuberculous, environmental mycobacteria. Patients are also susceptible to the more virulent species Mycobacterium tuberculosis.
domain 1 - 419 The leucine-zipper domain and the C2HC-type zinc-finger are essential for polyubiquitin binding and for the activation of IRF3.
Function 1 - 419 Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa- B-mediated protection from cytokine toxicity (By similarity). Essential for viral activation of IRF3.
interaction 1 - 419 O15111:CHUK; NbExp=3; IntAct=EBI-81279, EBI-81249; Q9UNS2:COPS3; NbExp=1; IntAct=EBI-81279, EBI-350590; O14920:IKBKB; NbExp=3; IntAct=EBI-81279, EBI-81266; Q9Y6Q9:NCOA3; NbExp=1; IntAct=EBI-81279, EBI-81196; Q13546:RIPK1; NbExp=1; IntAct=EBI-81279, EBI-358507; P12931:SRC; NbExp=1; IntAct=EBI-81279, EBI-621482; Q8NFZ5:TNIP2; NbExp=2; IntAct=EBI-81279, EBI-359372;
ptm 1 - 419 Phosphorylation at Ser-68 attenuates aminoterminal homodimerization.
ptm 1 - 419 Polyubiquitinated on Lys-285 through 'Lys-63'; the ubiquitination is mediated by NOD2 and RIPK2 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Polyubiquitinated on Lys-399 through 'Lys-63'; the ubiquitination is mediated by BCL10, MALT1 and TRAF6 and probably plays a role in signaling by facilitating interactions with ubiquitin domain- containing proteins and activates the NF-kappa-B pathway. Monoubiquitinated on Lys-277 and Lys-309; promotes nuclear export. Linear polyubiquitinated on Lys-285; the head-to-tail polyubiquitination is mediated by the LUBAC complex. Linear polyubiquitinated on Lys-309; the head-to-tail polyubiquitination is mediated by the LUBAC complex.
ptm 1 - 419 Sumoylated on Lys-277 and Lys-309 by SUMO1; the modification results in phosphorylation of Ser-85 by ATM leading to a replacement of the sumoylation by mono-ubiquitination on these residues.
Similarity 1 - 419 Contains 1 C2HC-type zinc finger.
Subcellular Location 1 - 419 Cytoplasm. Nucleus. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.
Subunit 1 - 419 Homodimer; disulfide-linked. Component of the I-kappa-B- kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD, NALP2, TRPC4AP and LRDD. Interacts with ATM; the complex is exported from the nucleus. Interacts with TRAF6. Interacts with HTLV-1 Tax oncoprotein; the interaction activates IKBKG. Interacts with TANK; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with ZFAND5.
Tissue Specificity 1 - 419 Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
web resource 1 - 419 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/IKBKG";
web resource 1 - 419 Name=IKBKGbase; Note=IKBKG mutation db; URL="http://bioinf.uta.fi/IKBKGbase/";
arrayexpress 1 - 419 Q9Y6K9
bgee 1 - 419 Q9Y6K9
cleanex 1 - 419 HS_IKBKG
ctd 1 - 419 8517
dip 1 - 419 DIP-27528N
doi 1 - 419 10
embl 1 - 419 AF062089
embl 1 - 419 AF074382
embl 1 - 419 AF091453
embl 1 - 419 AF261086
embl 1 - 419 AJ271718
embl 1 - 419 BC000299
embl 1 - 419 BC012114
embl 1 - 419 BC050612
embl 1 - 419 BT019621
ensembl 1 - 419 ENST00000369601
ensembl 1 - 419 ENST00000369606
ensembl 1 - 419 ENST00000369607
ensembl 1 - 419 ENST00000369609
genecards 1 - 419 GC0XP153769
geneid 1 - 419 8517
genevestigator 1 - 419 Q9Y6K9
germonline 1 - 419 ENSG00000073009
go 1 - 419 GO:0004871
go 1 - 419 GO:0005634
go 1 - 419 GO:0006350
go 1 - 419 GO:0006917
go 1 - 419 GO:0006955
go 1 - 419 GO:0006974
go 1 - 419 GO:0019904
go 1 - 419 GO:0044419
go 1 - 419 GO:0046872
go 1 - 419 GO:0050852
go 1 - 419 GO:0051092
h-invdb 1 - 419 HIX0017162
hgnc 1 - 419 HGNC:5961
hovergen 1 - 419 HBG000417
hpa 1 - 419 CAB010373
hpa 1 - 419 HPA000426
inparanoid 1 - 419 Q9Y6K9
intact 1 - 419 Q9Y6K9
interpro 1 - 419 IPR021063
ipi 1 - 419 IPI00002411
kegg 1 - 419 hsa:8517
medline 1 - 419 20296353
medline 1 - 419 20403900
medline 1 - 419 20530236
medline 1 - 419 21135089
medline 1 - 419 21163376
medline 1 - 419 21264955
medline 1 - 419 21968797
medline 1 - 419 98421680
medline 1 - 419 99108125
medline 1 - 419 99128359
medline 1 - 419 99189402
medline 1 - 419 99292691
mim 1 - 419 300248
mim 1 - 419 300291
mim 1 - 419 300301
mim 1 - 419 300584
mim 1 - 419 300636
mim 1 - 419 300640
mim 1 - 419 308300
mint 1 - 419 MINT-128245
nextbio 1 - 419 31882
orphanet 1 - 419 464
orphanet 1 - 419 69088
orphanet 1 - 419 98813
pathway_interaction_db 1 - 419 bcr_5pathway
pathway_interaction_db 1 - 419 cd8tcrpathway
pathway_interaction_db 1 - 419 fcer1pathway
pathway_interaction_db 1 - 419 il1pathway
pathway_interaction_db 1 - 419 nfkappabcanonicalpathway
pathway_interaction_db 1 - 419 p75ntrpathway
pathway_interaction_db 1 - 419 tcrpathway
pathway_interaction_db 1 - 419 tnfpathway
pathway_interaction_db 1 - 419 trail_pathway
pdb 1 - 419 2JVX
pdb 1 - 419 2JVY
pdb 1 - 419 3BRT
pdb 1 - 419 3BRV
pdb 1 - 419 3CL3
pdb 1 - 419 3FX0
pdbsum 1 - 419 2JVX
pdbsum 1 - 419 2JVY
pdbsum 1 - 419 3BRT
pdbsum 1 - 419 3BRV
pdbsum 1 - 419 3CL3
pdbsum 1 - 419 3FX0
pfam 1 - 419 PF11577
pharmgkb 1 - 419 PA29777
phosphosite 1 - 419 Q9Y6K9
phylomedb 1 - 419 Q9Y6K9
pride 1 - 419 Q9Y6K9
proteinmodelportal 1 - 419 Q9Y6K9
pubmed 1 - 419 10087442
pubmed 1 - 419 10364167
pubmed 1 - 419 10839543
pubmed 1 - 419 10944468
pubmed 1 - 419 11047757
pubmed 1 - 419 11064457
pubmed 1 - 419 11080499
pubmed 1 - 419 11224521
pubmed 1 - 419 11242109
pubmed 1 - 419 11418127
pubmed 1 - 419 11590134
pubmed 1 - 419 11971985
pubmed 1 - 419 12045264
pubmed 1 - 419 12133833
pubmed 1 - 419 12612076
pubmed 1 - 419 12657630
pubmed 1 - 419 12917691
pubmed 1 - 419 14651848
pubmed 1 - 419 14695475
pubmed 1 - 419 14754897
pubmed 1 - 419 15100680
pubmed 1 - 419 15125833
pubmed 1 - 419 15229184
pubmed 1 - 419 15356572
pubmed 1 - 419 15456791
pubmed 1 - 419 15489334
pubmed 1 - 419 15620648
pubmed 1 - 419 16360037
pubmed 1 - 419 16497931
pubmed 1 - 419 16818673
pubmed 1 - 419 16950813
pubmed 1 - 419 17135271
pubmed 1 - 419 17728323
pubmed 1 - 419 17977820
pubmed 1 - 419 18164680
pubmed 1 - 419 18313693
pubmed 1 - 419 18462684
pubmed 1 - 419 18669648
pubmed 1 - 419 19136968
pubmed 1 - 419 19369195
pubmed 1 - 419 19854139
pubmed 1 - 419 9751060
pubmed 1 - 419 9891086
pubmed 1 - 419 9927690
reactome 1 - 419 REACT_6900
refseq 1 - 419 NP_001093326.2
refseq 1 - 419 NP_001093327.1
refseq 1 - 419 NP_001138727.1
refseq 1 - 419 NP_003630.1
string 1 - 419 Q9Y6K9
ucsc 1 - 419 uc004flz.1
unigene 1 - 419 Hs.43505
chain 1 - 419 NF-kappa-B essential modulator /FTId=PRO_0000096782.
coiled 49 - 356 Potential
conflict 341 - 341 S -> R (in Ref. 1; AAD12183)
conflict 387 - 387 S -> R (in Ref. 1; AAD12183)
crosslnk 277 - 277 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate.
crosslnk 277 - 277 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate.
crosslnk 285 - 285 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
crosslnk 309 - 309 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate.
crosslnk 309 - 309 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate.
crosslnk 321 - 321 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) (By similarity).
crosslnk 325 - 325 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) (By similarity).
crosslnk 326 - 326 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) (By similarity).
crosslnk 399 - 399 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
disulfid 54 - 54 Interchain
disulfid 347 - 347 Interchain
domain 322 - 343 Leucine-zipper (Potential)
Modification 31 - 31 Phosphoserine; by IKKB
Modification 43 - 43 Phosphoserine; by IKKB
Modification 68 - 68 Phosphoserine
Modification 85 - 85 Phosphoserine; by ATM
Modification 374 - 374 Phosphotyrosine
Modification 376 - 376 Phosphoserine; by IKKB
Modification 377 - 377 Phosphoserine
Modification 387 - 387 Phosphoserine
mutagen 68 - 68 S->A: Increases formation of homodimers
mutagen 68 - 68 S->E: Abolishes interaction with IKBKB; abolishes TNF-alpha induced NF-kappa-B activity.
mutagen 85 - 85 S->A: Decreases ubiquitination and abolishes nuclear export.
mutagen 115 - 115 K->R: No change in the ubiquitination level; when associated with R-399.
mutagen 224 - 224 K->R: No change in the ubiquitination level; when associated with R-399.
mutagen 277 - 277 K->A: Partial abolition of sumoylation Abolishes sumoylation and IKK activation; when associated with A-309.
mutagen 285 - 285 K->R: Important decrease in the ubiquitination level; when associated with R-399.
mutagen 309 - 309 K->A: Partial abolition of sumoylation Abolishes sumoylation and IKK activation; when associated with A-277.
mutagen 399 - 399 K->R: Abolishes BCL10-mediated but not RIPK2-mediated ubiquitination. Important decrease in the ubiquitination level; when associated with R-285. No change in the ubiquitination level; when associated with R-115 or R-224.
region 44 - 111 Interaction with CHUK/IKBKB
region 150 - 257 Interaction with TANK
region 246 - 365 Self-association
region 382 - 419 Interaction with CYLD
variant 57 - 57 E -> K (in IP; shows the same luciferase activity as the control). /FTId=VAR_026491.
variant 90 - 90 Missing (in IP; only 46.3% of the activation obtained with the wild-type protein). /FTId=VAR_026492.
variant 113 - 113 D -> N (in IP; shows the same luciferase activity as the control). /FTId=VAR_026493.
variant 123 - 123 R -> W (in IP; shows the same luciferase activity as the control). /FTId=VAR_026494.
variant 153 - 153 L -> R (in EDAID) /FTId=VAR_026495.
variant 173 - 173 R -> G (in IPD2) /FTId=VAR_031958.
variant 175 - 175 R -> P (in EDAID) /FTId=VAR_011320.
variant 227 - 227 L -> P (in EDAID) /FTId=VAR_011321.
variant 288 - 288 A -> G (in EDAID) /FTId=VAR_011322.
variant 311 - 311 D -> N (in EDAID) /FTId=VAR_011323.
variant 315 - 315 E -> A (in AMCBX1) /FTId=VAR_031959.
variant 319 - 319 R -> Q (in AMCBX1) /FTId=VAR_031960.
variant 323 - 323 A -> P (in IP; diminishes interaction with TRAF6 and polyubiquitination). /FTId=VAR_042666.
variant 406 - 406 D -> V (in EDAID) /FTId=VAR_011324.
variant 407 - 407 M -> V (in IP) /FTId=VAR_009182.
variant 417 - 417 C -> F (in EDAID) /FTId=VAR_011325.
variant 417 - 417 C -> R (in EDAID; loss of sumoylation) /FTId=VAR_011326.
variant 417 - 417 C -> Y (in EDAID) /FTId=VAR_026496.
zn_fing 396 - 417 C2HC-type
keyword 1 - 419 3D-structure
keyword 1 - 419 Coiled coil
keyword 1 - 419 Complete proteome
keyword 1 - 419 Cytoplasm
keyword 1 - 419 Direct protein sequencing
keyword 1 - 419 Disease mutation
keyword 1 - 419 Disulfide bond
keyword 1 - 419 Ectodermal dysplasia
keyword 1 - 419 Host-virus interaction
keyword 1 - 419 Isopeptide bond
keyword 1 - 419 Metal-binding
keyword 1 - 419 Nucleus
keyword 1 - 419 Osteopetrosis
keyword 1 - 419 Phosphoprotein
keyword 1 - 419 Transcription
keyword 1 - 419 Transcription regulation
keyword 1 - 419 Ubl conjugation
keyword 1 - 419 Zinc
keyword 1 - 419 Zinc-finger
Molecular Weight 1 - 419 48198
1 hit 1 - 419 PF11577

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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