HDAC1

histone deacetylase 1

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

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Antibodies (128)

ELISA Kits (15)

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HDAC1 (149)

Reactivity

Human (134)

Mouse (73)

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Purified (1)

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IHC-plus™ HDAC1 Antibody (clone 3E1) LS-B6094

(4.0) Rating

Antibody:

HDAC1 Mouse anti-Human Monoclonal (3E1) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ HDAC1 Antibody (aa450-482) LS-B34

(4.0) Rating

Antibody:

HDAC1 Rabbit anti-Human Polyclonal (aa450-482) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$515

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Human HDAC1 Protein (Recombinant His-SUMO) (Full Length) - LS-G20812

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

71.1 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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IHC-plus™ HDAC1 Antibody LS-B4088

(4.0) Rating

Antibody:

HDAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ HDAC1 Antibody (clone 1D6) LS-B6095

(4.0) Rating

Antibody:

HDAC1 Mouse anti-Human Monoclonal (1D6) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

IHC-plus™ HDAC1 Antibody (clone 5C11) LS-B6097

(4.0) Rating

Antibody:

HDAC1 Mouse anti-Human Monoclonal (5C11) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, PLA, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ HDAC1 Antibody (clone 5A11) LS-B6096

(4.0) Rating

Antibody:

HDAC1 Mouse anti-Human Monoclonal (5A11) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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HDAC1 Antibody (phospho-Ser421/423) LS-C178141

Antibody:

HDAC1 Rabbit anti-Human Polyclonal (pSer421/423) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

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HDAC1 Antibody (aa450-482) LS-C745294

Antibody:

HDAC1 Rabbit anti-Human Polyclonal (aa450-482) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

25 µl/$304

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IHC-plus™ HDAC1 Antibody (aa433-482) LS-B8386

(4.0) Rating

Antibody:

HDAC1 Rabbit anti-Human Polyclonal (aa433-482) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

HDAC1 Antibody LS-C192668

Antibody:

HDAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$391; 100 µl/$489

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HDAC1 Antibody (aa469-480) LS-C154779

Antibody:

HDAC1 Goat anti-Human Polyclonal (aa469-480) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Rat, Hamster, Human, Monkey

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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HDAC1 Antibody (360-440 aa) LS-C380944

Antibody:

HDAC1 Rabbit anti-Human Polyclonal (360-440 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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HDAC1 Antibody (phospho-Ser421/Ser423) LS-C291504

Antibody:

HDAC1 Rabbit anti-Human Polyclonal (pSer421/Ser423) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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HDAC1 Antibody (C-Terminus) LS-C352326

Antibody:

HDAC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Rabbit, Mouse, Rat, Human

Applications:

Flo, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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HDAC1 Antibody (aa385-396) LS-C154987

Antibody:

HDAC1 Goat anti-Human Polyclonal (aa385-396) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Horse, Human, Monkey

Applications:

ChrIP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

IHC-plus™ HDAC1 Antibody (aa387-436) LS-B8372

(4.0) Rating

Antibody:

HDAC1 Rabbit anti-Human Polyclonal (aa387-436) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

HDAC1 Antibody LS-C330858

Antibody:

HDAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539

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HDAC1 Antibody LS-C666093

Antibody:

HDAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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HDAC1 Antibody LS-C825963

Antibody:

HDAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

HDAC1 Antibody (clone 10E2) LS-C827976

Antibody:

HDAC1 Mouse anti-Human Monoclonal (10E2) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ChrIP, Flo, ICC, IF, IHC-P, IP, WB

Format:

Unconjugated

Price:

0.1 mg/$482

Select

HDAC1 Antibody LS-C377253

Antibody:

HDAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ChrIP, ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

HDAC1 Antibody LS-C415876

Antibody:

HDAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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HDAC1 Antibody LS-C486898

Antibody:

HDAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

Select

HDAC1 Antibody LS-C800302

Antibody:

HDAC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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