CDK9

cyclin-dependent kinase 9

Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.

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Antibodies (53)

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CDK9 (60)

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IHC-plus™ CDK9 Antibody (N-Terminus and C-Terminus) LS-B354

(5.0) Rating

(5) Publication(s)

Antibody:

CDK9 Rabbit anti-Human Polyclonal (N-Terminus and C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, ICC, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$515

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CDK9 Antibody (C Terminus) LS-C742567

Antibody:

CDK9 Goat anti-Mouse Polyclonal (C Terminus) Antibody

Reactivity:

Mouse

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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CDK9 Antibody (C-Terminus) LS-C79012

Antibody:

CDK9 Rabbit anti-Human Monoclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

20 µl/$469; 100 µl/$702

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CDK9 Antibody (aa251-278, Azide-free, HRP) LS-C254484

Antibody:

CDK9 Rabbit anti-Human Polyclonal (aa251-278) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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CDK9 Antibody (N-Terminus) LS-B6966

Antibody:

CDK9 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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CDK9 Antibody (N-Terminus, HRP) LS-C481180

Antibody:

CDK9 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Chicken, Dog, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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CDK9 Antibody (N-Terminus, Biotin) LS-C481178

Antibody:

CDK9 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Chicken, Dog, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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CDK9 Antibody (N-Terminus, FITC) LS-C481179

Antibody:

CDK9 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Chicken, Dog, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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CDK9 Antibody (clone 1B5A7) LS-C169361

Antibody:

CDK9 Mouse anti-Human Monoclonal (1B5A7) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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CDK9 Antibody (clone 2D7) LS-C196884

Antibody:

CDK9 Mouse anti-Human Monoclonal (2D7) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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Human CDK9 Protein (Recombinant His-T7) (aa104-315) - LS-G24039

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.3 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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CDK9 Antibody (clone 1B5D10) LS-C169362

Antibody:

CDK9 Mouse anti-Human Monoclonal (1B5D10) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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CDK9 Antibody LS-C812544

Antibody:

CDK9 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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CDK9 Antibody (aa322-372) LS-C290167

Antibody:

CDK9 Rabbit anti-Human Polyclonal (aa322-372) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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CDK9 Antibody (aa153-372) LS-C375447

Antibody:

CDK9 Rabbit anti-Human Polyclonal (aa153-372) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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CDK9 Antibody LS-C752834

Antibody:

CDK9 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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CDK9 Antibody LS-C490212

Antibody:

CDK9 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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CDK9 Antibody (aa141-372) LS-C407750

Antibody:

CDK9 Rabbit anti-Human Polyclonal (aa141-372) Antibody

Reactivity:

Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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CDK9 Antibody (clone 1B5A7) LS-C758936

Antibody:

CDK9 Mouse anti-Human Monoclonal (1B5A7) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$541

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CDK9 Antibody LS-C341143

Antibody:

CDK9 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

CDK9 Antibody (clone 1B5D10) LS-C758940

Antibody:

CDK9 Mouse anti-Human Monoclonal (1B5D10) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$541

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CDK9 Antibody (phospho-Thr29) LS-C60108

Antibody:

CDK9 Rabbit anti-Human Polyclonal (pThr29) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$567

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CDK9 Antibody LS-C408256

Antibody:

CDK9 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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CDK9 Antibody (130-210 aa) LS-C380960

Antibody:

CDK9 Rabbit anti-Human Polyclonal (130-210 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

CDK9 Antibody (phospho-Thr186) LS-C822562

Antibody:

CDK9 Rabbit anti-Human Polyclonal (pThr186) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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