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c-Maf

v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog

Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.

Gene Name: v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
Synonyms: MAF, C-MAF, CCA4, C-maf proto-oncogene, Proto-oncogene c-Maf, T lymphocyte c-maf long form, Transcription factor Maf
Target Sequences: NM_005360 NP_005351.2 O75444

Publications (1)

1
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer. Min Liu, Zan Tong, Chuanlin Ding, Fengling Luo, Shouzhen Wu, Caijun Wu, Sabrin Albeituni, Liqing He, Xiaoling Hu, David Tieri, Eric C Rouchka, Michito Hamada, Satoru Takahashi, Andrew A Gibb, Goetz Kloecker, Huang-Ge Zhang, Michael Bousamra nd, Bradford G Hill, Xiang Zhang, Jun Yan. The Journal of clinical investigation. 2020 April;130:2081-2096. [Full Text Article] [PubMed:31945018] [PMC:PMC7108920] Related Antibodies: LS-C287488.

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Antibodies (50)
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c-Maf (61)
Human (46)
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c-Maf Antibody - Detection of Mouse cMaf by Western Blot. Samples: Nuclear extract (6 ug) from HeLa cells transfected with empty vector or expression constructs for mouse MafA, mouse MafB or mouse cMaf. Antibodies: Affinity purified rabbit anti-cMaf antibody used at 0.4 ug/ml. Detection: Chemiluminescence.
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c-Maf Rabbit anti-Mouse Polyclonal (aa150-200) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
10 µl/$295; 100 µl/$520
c-Maf Antibody - Anti-MAF antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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c-Maf Rabbit anti-Human Polyclonal (aa50-100) Antibody
Zebrafish, Rat, Mouse, Dog, Bovine, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$460
c-Maf Antibody - Western blot analysis of c-Maf expression in Ramos (A); HUVEC (B); HeLa (C) whole cell lysates.
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c-Maf Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Zebrafish, Bovine, Mouse, Rat, Human
IP, WB
Unconjugated
100 µl/$299
c-Maf Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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c-Maf Rabbit anti-Human Polyclonal (aa301-350) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
c-Maf Antibody - Anti-MAF antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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c-Maf Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
c-Maf Antibody - Anti-MAF antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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c-Maf Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Xenopus, Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Chimpanzee, Human, Monkey, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
c-Maf Antibody - Anti-MAF antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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c-Maf Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Chimpanzee, Human, Monkey, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
c-Maf Antibody - Anti-MAF antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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c-Maf Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Xenopus, Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Chimpanzee, Human, Monkey, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
c-Maf Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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c-Maf Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC-P, IP, WB
Unconjugated
50 µg/$460
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c-Maf Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
c-Maf ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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c-Maf Rabbit Recombinant Monoclonal Antibody
ICC, IHC, IP, WB
Unconjugated
10 µl/$299; 100 µl/$548
c-Maf Antibody - Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue  using MAF Polyclonal Antibody at dilution of 1:25(×200)
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c-Maf Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
c-Maf Antibody - Immunohistochemistry image of paraffin-embedded human small intestine tissue at a dilution of 1:100
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c-Maf Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
c-Maf Antibody - Staining HuvEc cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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c-Maf Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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c-Maf Rabbit anti-Mouse Polyclonal (aa14-42) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
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c-Maf Rabbit anti-Mouse Polyclonal (aa14-42) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
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c-Maf Rabbit anti-Mouse Polyclonal (aa14-42) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
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c-Maf Rabbit anti-Mouse Polyclonal (aa14-42) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
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c-Maf Rabbit anti-Mouse Polyclonal (aa14-42) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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c-Maf Rabbit anti-Mouse Polyclonal (aa14-42) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
c-Maf Antibody - MAF monoclonal antibody (M02), clone 6B8. Western blot of MAF expression in PC-12.
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c-Maf Mouse anti-Human Monoclonal (6B8) Antibody
Rat, Human
ELISA, WB
Unconjugated
100 µg/$423
c-Maf Antibody - Western blot analysis of extracts from HuvEc cells, HepG2 cells, HeLa cells and COLO205 cells, using Maf antibody.
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c-Maf Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
c-Maf Antibody - Western blot of c-Maf antibody
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c-Maf Rabbit anti-Human Polyclonal (270-350 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
c-Maf Antibody - Western blot analysis of the lysates from HeLa cells using Maf antibody.
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c-Maf Rabbit anti-Human Polyclonal (aa287-336) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Viewing 1-25 of 61 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).