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XRCC3

X-ray repair complementing defective repair in Chinese hamster cells 3

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

Gene Name:	X-ray repair complementing defective repair in Chinese hamster cells 3
Synonyms:	XRCC3, DNA repair protein XRCC3, CMM6
Target Sequences:	NM_005432 NP_005423.1 O43542

Publications (15)

XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells. Yoshihara T, Ishida M, Kinomura A, Katsura M, Tsuruga T, Tashiro S, Asahara T, Miyagawa K. The EMBO journal. 2004 23:670-80. (IP; Human) [PubMed:14749735] [PMC:PMC1271813]

Xrcc3 is recruited to DNA double strand breaks early and independent of Rad51. Forget AL, Bennett BT, Knight KL. Journal of cellular biochemistry. 2004 93:429-36. (ICC) [PubMed:15372620]

Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG. Cancer research. 2004 64:8526-33. [PubMed:15574758]

Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. Bennett BT, Knight KL. Journal of cellular biochemistry. 2005 96:1095-109. [PubMed:16215984]

Role for RAD18 in homologous recombination in DT40 cells. Szts D, Simpson LJ, Kabani S, Yamazoe M, Sale JE. Molecular and cellular biology. 2006 26:8032-41. [PubMed:16923963] [PMC:PMC1636725]

Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Nagaraju G, Odate S, Xie A, Scully R. Molecular and cellular biology. 2006 26:8075-86. [PubMed:16954385] [PMC:PMC1636746]

Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells. Compton SA, Choi JH, Cesare AJ, Ozgr S, Griffith JD. Cancer research. 2007 67:1513-9. [PubMed:17308089]

Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow RG. Cancer research. 2008 68:605-14. [PubMed:18199558]

WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Li B, Jog SP, Reddy S, Comai L. Molecular and cellular biology. 2008 28:1892-904. [PubMed:18212065] [PMC:PMC2268394]

Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC. Blood. 2009 113:2290-7. [PubMed:19050310] [PMC:PMC2652372]

The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction. Katsura M, Tsuruga T, Date O, Yoshihara T, Ishida M, Tomoda Y, Okajima M, Takaku M, Kurumizaka H, Kinomura A, Mishima HK, Miyagawa K. Nucleic acids research. 2009 37:3959-68. [PubMed:19403737] [PMC:PMC2709562]

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links. Al-Minawi AZ, Lee YF, Hkansson D, Johansson F, Lundin C, Saleh-Gohari N, Schultz N, Jenssen D, Bryant HE, Meuth M, Hinz JM, Helleday T. Nucleic acids research. 2009 37:6400-13. [PubMed:19713438] [PMC:PMC2770670]

Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C. Gildemeister OS, Sage JM, Knight KL. The Journal of biological chemistry. 2009 284:31945-52. [PubMed:19783859] [PMC:PMC2797266]

Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. Sage JM, Gildemeister OS, Knight KL. The Journal of biological chemistry. 2010 285:18984-90. [PubMed:20413593] [PMC:PMC2885175]

Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta. Nicolay NH, Carter R, Hatch SB, Schultz N, Prevo R, McKenna WG, Helleday T, Sharma RA. Carcinogenesis. 2012 33:2026-34. (WB; Human) [PubMed:22822095] [PMC:PMC3584963]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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