Human TP53 / p53

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1,k Monoclonal

Pab122

Unconjugated

Purified

Concentrated

Recombinant human p53 protein. Splenocytes were fused with mouse myeloma P3-X63/AG8.653 cells.

The p53 gene is located on human chromosome 17p13.1. Mutation and/or allelic loss of this gene is one of the causes of the occurrence of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. P53 binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). P53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution.

• IHC
• IHC - Paraffin
• IHC - Frozen
• Western blot
• Flow Cytometry
• ELISA

PBS, 0.05% Sodium Azide

Store at 2-8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P04637 NCBI: NM_000546 NP_000537.3