Mouse TNFSF10 / TRAIL

Rat

Mouse (tested or 100% immunogen sequence identity)

IgG2a Monoclonal

N2B2

Unconjugated

Affinity purified

Unmodified

Mouse CD253-transfected 2PK-3 cells.

Recognizes mouse CD253, also known as TNF-related apoptosis-inducing ligand or TRAIL, a member of the tumor necrosis factor ligand superfamily. When bound to the death receptors DR4 and DR5 caspase-8-dependent apoptosis is induced. However, CD253 might also be bound by the decoy receptor DcR1 which cannot induce apoptosis, and DcR2 which activates NF-kappa-B. Clone N2B2 has been reported to block NK cell cytotoxicity in vitro.

• Flow Cytometry (1:5 - 1:10)

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P50591 NCBI: NM_003810 NP_003801.1