SMAD2

SMAD family member 2

SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

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Products

Antibodies (153)

Proteins (17)

ELISA Kits (15)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (2)

DNA Binding (1)

DNA Binding Phosphorylation (1)

Over-Expression Lysate (7)

Primary (153)

Recombinant (10)

Sandwich (8)

Target

SMAD2 (185)

Reactivity

Human (150)

Mouse (94)

Rat (79)

Bat (12)

Bovine (19)

Chicken (14)

Chimpanzee (6)

Dog (12)

Drosophila (3)

Gibbon (9)

Guinea pig (10)

Hamster (7)

Horse (12)

Monkey (16)

Orangutan (9)

Pig (14)

Rabbit (16)

Sheep (4)

Xenopus (10)

Zebrafish (11)

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Application

IHC (37)

IHC-Fr (1)

IHC-P (14)

WB (138)

Flo (7)

DB (7)

ELISA (50)

ICC (8)

IF (31)

IP (3)

Peptide-ELISA (14)

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Host

rabbit (140)

mouse (12)

goat (1)

Product Group

IHCPlus (4)

Isotype

IgG (91)

IgG1 (3)

IgG2b (4)

IgG2b,k (2)

Clonality

monoclonal mc (12)

polyclonal pc (140)

recombinant monoclonal rmc (1)

Clone

3G6 (1)

3G9 (1)

4D10 (1)

5G7 (1)

OTI2C10 (2)

OTI4G7 (2)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (4)

96-Well Strip Plate (9)

APC (2)

APC Conjugated (8)

Azide-free (3)

Biotin Conjugated (12)

Carrier-free (2)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (12)

HRP Conjugated (12)

PE Conjugated (8)

Unconjugated (97)

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Epitope

N-Terminus (9)

aa272-467 (8)

aa273-467 (8)

pSer465/467 (8)

pSer467 (8)

Ser118 (7)

Thr220 (7)

pSer118 (7)

C-Terminus (6)

pSer250 (4)

410-490 aa (2)

Internal (2)

pSer465/Ser467 (2)

pThr220 (2)

160-240 aa (1)

190-270 aa (1)

400-480 aa (1)

Acetyl-Lys19 (1)

MH1 Domain (1)

Pro459 (1)

Ser2 (1)

Tyr216 (1)

aa106-140 (1)

aa186-235 (1)

aa186-273 (1)

aa198-232 (1)

aa202-251 (1)

aa211-260 (1)

aa216-265 (1)

aa221-270 (1)

aa234-249 (1)

aa418-467 (1)

aa82-94 (1)

aa94-112 (1)

p220 (1)

p245 (1)

p250 (1)

p255 (1)

p467 (1)

pSer245/Ser250/Ser255 (1)

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Publications

No (184)

Yes (1)

Sample Type

Adherent Cell Cultures (3)

Cell Culture Supernatants (1)

Cell Lysates (3)

Nuclear Lysates (2)

Plasma (7)

Serum (7)

Tissue Homogenates (3)

Tag

6His, N-terminus (1)

6His-DDK (Flag), C-terminus (1)

6His-SUMO, N-terminus (1)

GST, N-terminus (1)

His (3)

His, N-Terminal (1)

His-GST (1)

Myc-DDK (Flag) (8)

Species

Human (12)

Mouse (2)

Source

293T Cells (3)

Baculovirus (1)

E. coli (6)

HEK 293 Cells (6)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

Select

SMAD2 Antibody (phospho-Ser467) LS-C199582

(4.0) Rating

(1) Publication(s)

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (pSer467) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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IHC-plus™ SMAD2 Antibody (aa234-249) LS-B2063

(4.0) Rating

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (aa234-249) Antibody

Reactivity:

Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$440

Select

IHC-plus™ SMAD2 Antibody (clone 3G6) LS-B5454

(4.0) Rating

Antibody:

SMAD2 Mouse anti-Human Monoclonal (3G6) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$440

Select

IHC-plus™ SMAD2 Antibody (aa418-467) LS-B10160

(4.0) Rating

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (aa418-467) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

SMAD2 Antibody (Internal) LS-C352490

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Chicken, Zebrafish, Bovine, Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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SMAD2 Antibody (phospho-Ser467) LS-C801197

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (pSer467) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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SMAD2 Antibody (aa94-112) LS-C313039

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (aa94-112) Antibody

Reactivity:

Xenopus, Chicken, Sheep, Bovine, Rabbit, Mouse, Guinea pig, Rat, Pig, Horse, Bat, Human, Monkey

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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Mouse/Human/Rat Phospho-SMAD2 (Ser467) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1057

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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SMAD2 Antibody (Pro459) LS-C176301

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (Pro459) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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SMAD2 Antibody (clone 5G7) LS-C758951

Antibody:

SMAD2 Mouse anti-Human Monoclonal (5G7) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$528

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SMAD2 Antibody (phospho-Ser465/467) LS-C209429

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (pSer465/467) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$567

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SMAD2 Antibody LS-C417688

Antibody:

SMAD2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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Human SMAD2 (Sandwich ELISA) ELISA Kit - LS-F38230

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$771

Select

SMAD2 Antibody (clone OTI4G7) LS-C115681

Antibody:

SMAD2 Mouse anti-Human Monoclonal (OTI4G7) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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IHC-plus™ SMAD2 Antibody (Thr220) LS-B9109

(4.0) Rating

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (Thr220) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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SMAD2 Antibody (N-Terminus) LS-C171841

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$380

Select

SMAD2 Antibody LS-C812769

Antibody:

SMAD2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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SMAD2 Antibody LS-C679540

Antibody:

SMAD2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

SMAD2 Antibody LS-C801650

Antibody:

SMAD2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

SMAD2 Antibody (N-Terminus) LS-C31653

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

Select

SMAD2 Antibody (C-Terminus) LS-C413086

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Chicken, Zebrafish, Pig, Rabbit, Mouse, Sheep, Bovine, Rat, Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$321

Select

SMAD2 Antibody LS-C417645

Antibody:

SMAD2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

SMAD2 Antibody (aa186-235) LS-C117928

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (aa186-235) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

SMAD2 Antibody (410-490 aa) LS-C386108

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (410-490 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

SMAD2 Antibody (p220) LS-C822414

Antibody:

SMAD2 Rabbit anti-Human Polyclonal (p220) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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