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PTPN11 / SHP-2 / NS1
protein tyrosine phosphatase, non-receptor type 11
PTPN11 / SHP-2 / NS1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | protein tyrosine phosphatase, non-receptor type 11 |
| Family/Subfamily: | Protein Phosphatase , NT2 |
| Synonyms: | PTPN11, Bptp-3, BPTP3, CFC, Csw, Corkscrew csw, Gene corkscrew, Phosphatase corkscrew, PTP-2C, SHP2, PTP-1D, PTP2C, SHP-2, SHPTP2, Noonan syndrome 1, SH-PTP2, SH-PTP3 |
| Target Sequences: | NM_002834 NP_002825.3 Q06124 |
Publications (2)
1
The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells. Zhan Y, Counelis GJ, O'Rourke DM. Experimental cell research. 2009 315:2343-57. (WB)
[PubMed:19427850]
[PMC:PMC2724964]
2
Src homology phosphotyrosyl phosphatase-2 expression is an independent negative prognostic factor in human breast cancer. Muenst S, Obermann EC, Gao F, Oertli D, Viehl CT, Weber WP, Fleming T, Gillanders WE, Soysal SD. Histopathology. 2013 Jul;63:74-82. [Full Text Article]
[PubMed:23672411]
[PMC:PMC4100721]
Related Antibodies: LS-B542.
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PTPN11 / SHP-2 / NS1
(119)
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(111)
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(1)
HEK 293 Cells
(1)
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(3)
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(4)
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Low endotoxin level
(1)
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
PTPN11 / SHP-2 / NS1 Goat anti-Human Polyclonal (aa584-597) Antibody
Xenopus, Chicken, Bovine, Bat, Rabbit, Horse, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
PTPN11 / SHP-2 / NS1 Mouse anti-Human Monoclonal (6D9) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (pTyr542) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$315
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa520-547) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa543-593) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (290-370 aa, Internal) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
E. coli
6His, N-terminus
55 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
PTPN11 / SHP-2 / NS1 Mouse anti-Human Monoclonal (Amino Acid: 263-329) (6D9) Antibody
Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µg/$503
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (pTyr542) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Horse, Human, Monkey
IHC, WB
Unconjugated
50 µg/$489
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (pTyr580) Antibody
Human
IP, WB
Unconjugated
100 µl/$689
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa321-370) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa508-557) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (pTyr542) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (pTyr580) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa143-192) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa143-192) (Biotin) Antibody
Chicken, Mouse, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
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product results
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