MSH6

mutS homolog 6

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.

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Products

Antibodies (56)

Proteins (2)

Type

Primary (56)

Recombinant (2)

Target

MSH6 (58)

Reactivity

Human (55)

Mouse (14)

Rat (5)

Bat (1)

Dog (2)

Gibbon (3)

Guinea pig (3)

Monkey (9)

Application

IHC (28)

IHC-Fr (2)

IHC-P (22)

WB (38)

Flo (2)

ELISA (16)

ICC (6)

IF (14)

IP (3)

Peptide-ELISA (1)

Host

rabbit (26)

mouse (27)

goat (3)

Product Group

IHCPlus (2)

PathPlus Cancer (1)

PathPlus Cancer Pathology (1)

Isotype

IgG (21)

IgG1 (13)

IgG1,k (1)

IgG2a (3)

IgG2b,k (8)

Clonality

monoclonal mc (29)

polyclonal pc (26)

recombinant monoclonal rmc (1)

Clone

021 (1)

1F2 (1)

30 (2)

3A10H7 (2)

44 (3)

5B11 (2)

ABT-MSH6 (1)

MSH6/2111 (2)

MSH6/3085 (3)

MTS6-1 (3)

OTI5D1 (2)

UMAB258 (2)

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Format

Azide-free (3)

Biotin Conjugated (2)

BSA-free (3)

Carrier-free (2)

FITC Conjugated (2)

HRP Conjugated (2)

Preservative Free (2)

Ready-to-Use (3)

Unconjugated (50)

Epitope

aa1-280 (4)

aa1-400 (4)

aa251-300 (4)

aa350-400 (2)

310-390 aa, Internal (1)

C-Terminus (1)

Glu371 (1)

Internal (1)

aa1300-C-term (1)

aa2-14 (1)

aa217-395 (1)

aa341-390 (1)

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Publications

No (58)

Tag

GST, N-terminus (1)

His-SUMO (1)

Species

Human (2)

Source

E. coli (1)

Wheat Germ Extract (1)

Select

MSH6 Antibody (clone 30) LS-C169448

Antibody:

MSH6 Mouse anti-Human Monoclonal (30) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$459

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MSH6 Antibody (clone 021, Preservative Free) LS-C818756

Antibody:

MSH6 Rabbit anti-Human Monoclonal (Preservative Free) (021) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

Select

IHC-plus™ MSH6 Antibody (aa217-395, clone 5B11) LS-B10739

(4.0) Rating

Antibody:

MSH6 Mouse anti-Human Monoclonal (aa217-395) (5B11) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

MSH6 Antibody (clone 30) LS-C758472

Antibody:

MSH6 Mouse anti-Human Monoclonal (30) Antibody

Reactivity:

Human

Applications:

Flo, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$503

Select

MSH6 Antibody (clone MSH6/3085) LS-C782652

Antibody:

MSH6 Mouse anti-Human Monoclonal (MSH6/3085) Antibody

Reactivity:

Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

20 µg/$371; 100 µg/$574

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MSH6 Antibody (C-Terminus) LS-C191051

Antibody:

MSH6 Rabbit anti-Human Monoclonal (C-Terminus) Antibody

Reactivity:

Human, Monkey

Applications:

IF, WB

Format:

Unconjugated

Price:

100 µl/$665

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MSH6 Antibody (clone 44) LS-C312106

Antibody:

MSH6 Mouse anti-Human Monoclonal (44) Antibody

Reactivity:

Mouse, Dog, Rat, Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$340

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MSH6 Antibody (clone 44, Ready-to-Use) LS-C348526

Antibody:

MSH6 Mouse anti-Human Monoclonal (Ready-to-Use) (44) Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated, Ready-to-Use

Price:

3 ml/$316

• Unconjugated
• Unconjugated, Ready-to-Use

• Unconjugated
• Unconjugated, Ready-to-Use

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MSH6 Antibody (Internal) LS-C352291

Antibody:

MSH6 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

MSH6 Antibody LS-C666923

Antibody:

MSH6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

PathPlus™ MSH6 Antibody (aa350-400) LS-B16115

Cancer Pathology

Cancer

(5.0) Rating

Antibody:

MSH6 Goat anti-Human Polyclonal (aa350-400) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$485

Select

MSH6 Antibody LS-C331182

Antibody:

MSH6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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MSH6 Antibody LS-C332402

Antibody:

MSH6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

MSH6 Antibody (310-390 aa, Internal) LS-C383879

Antibody:

MSH6 Rabbit anti-Human Polyclonal (310-390 aa, Internal) Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

MSH6 Antibody LS-C666922

Antibody:

MSH6 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$371

Select

MSH6 Antibody (Glu371) LS-C176981

Antibody:

MSH6 Rabbit anti-Human Polyclonal (Glu371) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

IHC-plus™ MSH6 Antibody (aa2-14) LS-B5106

(4.0) Rating

Antibody:

MSH6 Goat anti-Human Polyclonal (aa2-14) Antibody

Reactivity:

Mouse, Rat, Bat, Human, Monkey

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

MSH6 Antibody (clone 1F2) LS-C197374

Antibody:

MSH6 Mouse anti-Human Monoclonal (1F2) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

MSH6 Antibody (aa1-400) LS-C369999

Antibody:

MSH6 Rabbit anti-Human Polyclonal (aa1-400) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

Human MSH6 Protein (Recombinant His-SUMO) (aa1-400) - LS-G20985

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

60.03 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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MSH6 Antibody (clone ABT-MSH6) LS-C744537

Antibody:

MSH6 Mouse anti-Human Monoclonal (ABT-MSH6) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$268; 100 µl/$316

Select

MSH6 Antibody (aa1-280, clone OTI5D1) LS-C794202

Antibody:

MSH6 Mouse anti-Human Monoclonal (aa1-280) (OTI5D1) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

MSH6 Antibody LS-C768279

Antibody:

MSH6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

MSH6 Antibody LS-C836172

Antibody:

MSH6 Rabbit Recombinant Monoclonal Antibody

Applications:

ICC, IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$299; 100 µl/$548

Select

MSH6 Antibody (Preservative Free) LS-C815655

Antibody:

MSH6 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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