MALIN / NHLRC1

NHL repeat containing E3 ubiquitin protein ligase 1

E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

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Products

Antibodies (5)

Proteins (3)

Type

Over-Expression Lysate (2)

Primary (5)

Recombinant (1)

Target

MALIN / NHLRC1 (8)

Reactivity

Human (5)

Mouse (2)

Rat (2)

Application

IHC (3)

IHC-P (1)

WB (5)

ELISA (3)

IF (2)

Host

rabbit (5)

Isotype

IgG (5)

Clonality

polyclonal pc (5)

Format

Unconjugated (5)

Publications

No (8)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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MALIN / NHLRC1 Antibody LS-C335697

Antibody:

MALIN / NHLRC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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MALIN / NHLRC1 Antibody LS-C676156

Antibody:

MALIN / NHLRC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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MALIN / NHLRC1 Antibody LS-C754369

Antibody:

MALIN / NHLRC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

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MALIN / NHLRC1 Antibody LS-C768541

Antibody:

MALIN / NHLRC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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MALIN / NHLRC1 Antibody LS-C676159

Antibody:

MALIN / NHLRC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

Human MALIN / NHLRC1 Protein (Recombinant GST, N-terminus) (aa137-246) - LS-G63945

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MALIN / NHLRC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93057

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.1 kDa

Price:

20 µg/$150

Select

MALIN / NHLRC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103604

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.1 kDa

Price:

100 µg/$494

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