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Anti-LAG3 / CD223 Antibody (clone C9B7W, RPE) LS-C44775

See our new LAG3 / CD223 ELISA Kits
Human LAG3 / CD223 ELISA Kit (Custom) - LS-F136
(kits do not necessarily contain the antibody listed on this page)

Ordering

Wt. Vol. Conc. Price
- 100 tst - $245

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Rat Monoclonal [clone C9B7W] (IgG1) to Mouse LAG3 / CD223
Mouse
Flow Cytometry
RPE Conjugated

Details

Mouse LAG3 / CD223
Rat
Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [C9B7W]
R. Phycoerythrin (RPE)
Protein G purified

Applications

Flow Cytometry (1:1 - 1:5)

Specificity and Use

LAG3 / CD223 antibody was raised against murine CD223 Ig fusion protein.
Recognizes murine lymphocyte activation gene-3 (LAG-3), a 70kD activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Recognizes an epitope within the D2 domain of CD223. The antibody is reported to block the in vitro function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II. XXX recommend the use of MCA2386EL for this purpose.
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors.

Packaging

Lyophilized, PBS, pH 7.4, 0.09% sodium azide, 1% BSA.
100 tst Distilled Water.
For research use only.

About LAG3 / CD223

P18627 NM_002286 P18627

LAG3 Antibody, CD223 antigen Antibody, LAG-3 Antibody, Protein FDC Antibody, CD223 Antibody, FDC Antibody, Lymphocyte-activation gene 3 Antibody

Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.

Requested From: United States
Date Requested: 10/24/2014

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