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JAG1 / Jagged 1

jagged 1

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).

Gene Name: jagged 1
Synonyms: JAG1, AGS, AHD, Alagille syndrome, CD339 antigen, HJ1, Jagged1, JAGL1, Jagged, Jagged 1, Protein jagged-1, AWS, CD339, Soluble protein jagged
Target Sequences: NM_000214 NP_000205.1 P78504

Publications (7)

1
Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma. Siar CH, Nakano K, Han PP, Nagatsuka H, Ng KH, Kawakami T. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2010 39:552-8. (IHC-P; Human) [PubMed:20337864] Related Antibodies: LS-B2442.
2
Notch4 overexpression in ameloblastoma correlates with the solid/multicystic phenotype. Siar CH, Nagatsuka H, Chuah KS, Rivera RS, Nakano K, Ng KH, Kawakami T. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2010 110:224-33. (IHC-P; Human) [PubMed:20659700] Related Antibodies: LS-B2442.
3
Immunolocalization of notch signaling protein molecules in a maxillary chondrosarcoma and its recurrent tumor. Siar CH, Ha KO, Aung LO, Nakano K, Tsujigiwa H, Nagatsuka H, Ng KH, Kawakami T. European journal of medical research. 2010 15:456-60. (IHC-P; Human) [Full Text Article] [PubMed:21156405] [PMC:PMC3352190] Related Antibodies: LS-B2442.
4
Notch signaling and ghost cell fate in the calcifying cystic odontogenic tumor. Siar CH, Kawakami T, Buery RR, Nakano K, Tomida M, Tsujigiwa H, Han PP, Nagatsuka H, Ng KH. European journal of medical research. 2011 16:501-6. (IHC-P; Human) [PubMed:22027644] [PMC:PMC3351808] Related Antibodies: LS-B2442.
5
Notch1 pathway in adrenocortical carcinomas: correlations with clinical outcome. Ronchi CL, Sbiera S, Altieri B, Steinhauer S, Wild V, Bekteshi M, Kroiss M, Fassnacht M, Allolio B. Endocrine-related cancer. 2015 22:531-43. (WB; Human) [Full Text Article] [PubMed:25979380]
6
Complex bile duct network formation within liver decellularized extracellular matrix hydrogels. Lewis PL, Su J, Yan M, Meng F, Glaser SS, Alpini GD, Green RM, Sosa-Pineda B, Shah RN. Scientific reports. 2018 August;8:12220. [Full Text Article] [PubMed:30111800] [PMC:PMC6093899]
7
3D mouse embryonic stem cell culture for generating inner ear organoids. Karl R Koehler, Eri Hashino. Nature protocols. 2014 May;9:1229-44. [Full Text Article] [PubMed:24784820] [PMC:PMC6453571]
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Antibodies (83)
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JAG1 / Jagged 1 (108)
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JAG1 / Jagged 1 Antibody - Anti-JAG1 / Jagged 1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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JAG1 / Jagged 1 Rabbit anti-Human Polyclonal (aa110-125) Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$555
JAG1 / Jagged 1 Antibody - Anti-JAG1 / Jagged 1 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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JAG1 / Jagged 1 Goat anti-Human Polyclonal (aa1197-1210) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
JAG1 / Jagged 1 Antibody - Immunohistochemistry - Jagged-1 Antibody.
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JAG1 / Jagged 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
500 µg/$606
JAG1 / Jagged 1 Antibody - Immunohistochemistry of Jagged1 antibody
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JAG1 / Jagged 1 Rabbit anti-Human Polyclonal (981-1030 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
JAG1 / Jagged 1 Antibody - Western blot analysis using CD339 mAb against human CD339 (AA: extra 47-212) recombinant protein. (Expected MW is 44.6 kDa)
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JAG1 / Jagged 1 Mouse anti-Human Monoclonal (7C7E1) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
JAG1 / Jagged 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$818
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JAG1 / Jagged 1 Rabbit anti-Human Polyclonal (aa110-125) Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
500 µg/$1,076
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HEK 293 Cells
Human IgG Fc, C-terminus
Less than 0.01 EU/µg protein (determined by LAL method).
~150 kDa (SDS-PAGE)
10 µg/$347; 50 µg/$498
JAG1 / Jagged 1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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JAG1 / Jagged 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.1 mg/$485
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JAG1 / Jagged 1 Mouse anti-Human Monoclonal (aa32-296) (CF) (11n115) Antibody
Human
Flo
CF Conjugated
100 Tests/$746
JAG1 / Jagged 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
JAG1 / Jagged 1 Antibody - Western blot analysis using CD339 mAb against HEK293 (1) and CD339 (AA: extra 47-212)-hIgGFc transfected HEK293 (2) cell lysate.
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JAG1 / Jagged 1 Mouse anti-Human Monoclonal (7C7H2) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
JAG1 / Jagged 1 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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JAG1 / Jagged 1 Rabbit anti-Human Polyclonal (aa836-1047) Antibody
Mouse, Pig, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
JAG1 / Jagged 1 Antibody - JAG1 Antibody western blot of K562 cell line lysates (35 ug/lane). The JAG1 antibody detected the JAG1 protein (arrow).
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JAG1 / Jagged 1 Rabbit anti-Human Polyclonal (aa1122-1150) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
JAG1 / Jagged 1 Protein - Adipogenesis inhibition of 3T3L-1 cells. 3T3L1 cells were maintained in DMEM supplemented with 10% FBS and penicillin-streptomycin. When the cells were confluently grown adipogenesis was initiated by adding IBMX, Dexamethasone, and insulin to 0.5mM, 1 uM, and 10 ug/ml, respectively and continued for 2 days (day 0). The medium was replaced every 2 days with new medium containing insulin in the presence or absence of 5 ug/ml of human Jagged1-Fc and human CD137-Fc as a control-Fc. Staining with Oil Red O was typically performed on day 7.
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HEK 293 Cells
Human IgG1 Fc
Less than 0.1 EU/µg protein (determined by LAL method).
~150kDa (SDS-PAGE)
50 µg/$470; 10 µg/$347
JAG1 / Jagged 1 Antibody - Western blot analysis using CD339 mAb against HEK293 (1) and CD339 (AA: extra 47-212)-hIgGFc transfected HEK293 (2) cell lysate.
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JAG1 / Jagged 1 Mouse anti-Human Monoclonal (6A9B2) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
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JAG1 / Jagged 1 Rabbit anti-Human Polyclonal (aa1122-1150) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
JAG1 / Jagged 1 Antibody
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JAG1 / Jagged 1 Rabbit anti-Human Polyclonal (aa469-746) Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$332
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JAG1 / Jagged 1 Mouse anti-Human Monoclonal (1E12) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$423
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JAG1 / Jagged 1 Mouse anti-Human Monoclonal (aa32-296) (TS106) Antibody
Human
Flo
Unconjugated
100 µg/$930
JAG1 / Jagged 1 Antibody - Western blot of recombinant JAG1 / Jagged 1.
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JAG1 / Jagged 1 Rabbit anti-Mouse Polyclonal (aa826-1084) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
JAG1 / Jagged 1 Antibody - Anti-Jag1 Antibody at 1:2000 dilution + mouse brain lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 134 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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JAG1 / Jagged 1 Rabbit anti-Mouse Polyclonal (aa1191-1224) Antibody
Mouse
WB
Unconjugated
400 µl/$393
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JAG1 / Jagged 1 Mouse anti-Human Monoclonal (APC) (11D68) Antibody
Human
Flo
APC Conjugated
100 Tests/$907
JAG1 / Jagged 1 Antibody - Immunohistochemical staining of human cervical cancer tissue (40X magnification) using the Protein A purified anti-Jagged-1 antibody. Tissue was fixed with formalin and embedded in paraffin. Hematoxylin was used to counter-stain cells. A 1:100 dilution of primary antibody was used.
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JAG1 / Jagged 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
25 µl/$304
JAG1 / Jagged 1 Antibody - Western blot of recombinant JAG1 / Jagged 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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JAG1 / Jagged 1 Rabbit anti-Human Polyclonal (aa470-834) Antibody
Rat, Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
Viewing 1-25 of 108 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).