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Anti-JAG1 / Jagged 1 Antibody (aa110-125) IHC-plus™ LS-B2442

See our new JAG1 / Jagged 1 ELISA Kits
Rat JAG1 / Jagged 1 ELISA Kit (Custom) - LS-F406
(kits do not necessarily contain the antibody listed on this page)

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $395

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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JAG1 / Jagged 1 Antibody LS-B2442 Images

[click image for a larger image and more details]
Immunohistochemistry
Anti-JAG1 / Jagged 1 antibody IHC of human kidney.

100% Guaranteed 100% Guaranteed Publications Publications (4)
Rabbit Polyclonal (IgG) to Human JAG1 / Jagged 1
Human
IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Unconjugated

Details

Human JAG1 / Jagged 1
Rabbit
Human (tested or 100% immunogen sequence identity)
Chimpanzee, Mouse, Rat (at least 90% immunogen sequence identity)
IgG Polyclonal
Protein A purified

Applications

IHC - Paraffin (5 µg/ml), ICC, Immunofluorescence (1:100 - 1:500), Western blot (1:250 - 1:1000), ELISA (1:2500 - 1:10000)

Specificity and Use

JAG1 / Jagged 1 antibody was raised against synthetic peptide corresponding to aa 110-125 of human Jagged-1protein.
aa110-125
Recognizes human Jagged1 (JAG1).
Immunohistochemistry: LS-B2442 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2442 was determined to be 5 ug/ml.

Packaging

PBS, pH 7.2, 0.01% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

Publications (4)

1
Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma. Siar CH, Nakano K, Han PP, Nagatsuka H, Ng KH, Kawakami T. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2010 39:552-8. (IHC-P; Human) [PubMed:20337864]
2
Notch4 overexpression in ameloblastoma correlates with the solid/multicystic phenotype. Siar CH, Nagatsuka H, Chuah KS, Rivera RS, Nakano K, Ng KH, Kawakami T. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2010 110:224-33. (IHC-P; Human) [PubMed:20659700]
3
Immunolocalization of notch signaling protein molecules in a maxillary chondrosarcoma and its recurrent tumor. Siar CH, Ha KO, Aung LO, Nakano K, Tsujigiwa H, Nagatsuka H, Ng KH, Kawakami T. European journal of medical research. 2010 15:456-60. (IHC-P; Human) [PubMed:21156405] [PMC:PMC3352190]
4
Notch signaling and ghost cell fate in the calcifying cystic odontogenic tumor. Siar CH, Kawakami T, Buery RR, Nakano K, Tomida M, Tsujigiwa H, Han PP, Nagatsuka H, Ng KH. European journal of medical research. 2011 16:501-6. (IHC-P; Human) [PubMed:22027644] [PMC:PMC3351808]
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About JAG1 / Jagged 1

P78504 NM_000214 NP_000205.1

JAG1 Antibody, AGS Antibody, AHD Antibody, Alagille syndrome Antibody, CD339 antigen Antibody, HJ1 Antibody, Jagged1 Antibody, JAGL1 Antibody, Jagged Antibody, Jagged 1 Antibody, Protein jagged-1 Antibody, AWS Antibody, CD339 Antibody, Soluble protein jagged Antibody

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophila jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophila jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

Immunohistochemistry

Immunohistochemistry
Anti-JAG1 / Jagged 1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2442 concentration 5 ug/ml.
 

Requested From: United States
Date Requested: 10/22/2014

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