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ITGAM / CD11b

integrin, alpha M (complement component 3 receptor 3 subunit)

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Gene Name:	integrin, alpha M (complement component 3 receptor 3 subunit)
Family/Subfamily:	Integrin , not assigned-Integrin
Synonyms:	ITGAM, Antigen CD11b (p170), CD11B, CD11b antigen, CR3A, Integrin alpha-M, MAC-1, MO1A, Neutrophil adherence receptor, MAC1A, SLEB6, CR-3 alpha chain
Target Sequences:	NM_000632 NP_000623.2 P11215

Publications (21)

Dissection of the hyperadhesive phenotype of airway eosinophils in asthma. Barthel SR, Jarjour NN, Mosher DF, Johansson MW. American journal of respiratory cell and molecular biology. 2006 35:378-86. [PubMed:16601240] [PMC:PMC1550734] Related Antibodies: LS-C40808.

Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia. Pillay J, Ramakers BP, Kamp VM, Loi AL, Lam SW, Hietbrink F, Leenen LP, Tool AT, Pickkers P, Koenderman L. Journal of leukocyte biology. 2010 88:211-20. [PubMed:20400675] Related Antibodies: LS-C40808.

Basophils and the T helper 2 environment can promote the development of lupus nephritis. Charles N, Hardwick D, Daugas E, Illei GG, Rivera J. Nature medicine. 2010 16:701-7. [PubMed:20512127] [PMC:PMC2909583] Related Antibodies: LS-C40807.

Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein. Yin L, Ahmad R, Kosugi M, Kawano T, Avigan D, Stone R, Kharbanda S, Kufe D. Cancer biology & therapy. 2010 10:483-91. (IHC; Human) [PubMed:20592495] [PMC:PMC3034602]

Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis. Thurlow LR, Thomas VC, Narayanan S, Olson S, Fleming SD, Hancock LE. Infection and immunity. 2010 78:4936-43. [PubMed:20713628] [PMC:PMC2976315] Related Antibodies: LS-C40807.

Toll-like receptor 4 mediates the response of epithelial and stromal cells to lipopolysaccharide in the endometrium. Sheldon IM, Roberts MH. PloS one. 2010 5:e12906. (IHC; Mouse) [PubMed:20877575] [PMC:PMC2943929]

The Vi capsular polysaccharide prevents complement receptor 3-mediated clearance of Salmonella enterica serotype Typhi. Wilson RP, Winter SE, Spees AM, Winter MG, Nishimori JH, Sanchez JF, Nuccio SP, Crawford RW, Tkel, Bumler AJ. Infection and immunity. 2011 79:830-7. [PubMed:21098104] [PMC:PMC3028862] Related Antibodies: LS-C40808.

Altered hippocampal synaptic transmission in transgenic mice with astrocyte-targeted enhanced CCL2 expression. Nelson TE, Hao C, Manos J, Ransohoff RM, Gruol DL. Brain, behavior, and immunity. 2011 S106-19. (WB; Mouse) [PubMed:21356306]

MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells. Yin L, Wu Z, Avigan D, Rosenblatt J, Stone R, Kharbanda S, Kufe D. Blood. 2011 117:4863-70. [PubMed:21422470] [PMC:PMC3100696]

Hax1 regulates neutrophil adhesion and motility through RhoA. Cavnar PJ, Berthier E, Beebe DJ, Huttenlocher A. The Journal of cell biology. 2011 193:465-73. [PubMed:21518791] [PMC:PMC3087009] Related Antibodies: LS-C40808.

Infection of dendritic cells with herpes simplex virus type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration. Theodoridis AA, Eich C, Figdor CG, Steinkasserer A. Blood. 2011 118:107-15. [PubMed:21562043] Related Antibodies: LS-C40808.

Neuroadaptive changes in cerebellar neurons induced by chronic exposure to IL-6. Gruol DL, Puro A, Hao C, Blakely P, Janneke E, Vo K. Journal of neuroimmunology. 2011 239:28-36. (WB; Rat) [PubMed:21890220] [PMC:PMC3428218]

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:16369-74. (IHC, WB, IHC-P; Mouse, Human) [PubMed:21911388] [PMC:PMC3182724]

Human eosinophils express RAGE, produce RAGE ligands, exhibit PKC-delta phosphorylation and enhanced viability in response to the RAGE ligand, S100B. Curran CS, Bertics PJ. International immunology. 2011 23:713-28. [PubMed:22025532] [PMC:PMC3226529] Related Antibodies: LS-C40808.

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL. Journal of molecular medicine (Berlin, Germany). 2012 90:803-15. (IHC; Mouse) [PubMed:22231744] [PMC:PMC3437551]

Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6. Nelson TE, Olde Engberink A, Hernandez R, Puro A, Huitron-Resendiz S, Hao C, De Graan PN, Gruol DL. Brain, behavior, and immunity. 2012 26:959-71. (WB; Mouse) [PubMed:22609298] [PMC:PMC3427030]

Effect of molecular size and modification pattern on the internalization of water soluble -(1 3)-(1 4)-glucan by primary murine macrophages. Zhang M, Kim JA. The international journal of biochemistry & cell biology. 2012 44:914-27. (ICC; Mouse) [PubMed:22679629]

Human suppressive neutrophils CD16bright/CD62Ldim exhibit decreased adhesion. Kamp VM, Pillay J, Lammers JW, Pickkers P, Ulfman LH, Koenderman L. Journal of leukocyte biology. 2012 92:1011-20. [PubMed:22927481] Related Antibodies: LS-C40808.

Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression. Bray JG, Reyes KC, Roberts AJ, Ransohoff RM, Gruol DL. Neuropharmacology. 2013 67:115-25. (WB; Mouse) [PubMed:23164616] [PMC:PMC3595200]

VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepatic ischemia/reperfusion injury. Ohkubo H, Ito Y, Minamino T, Eshima K, Kojo K, Okizaki S, Hirata M, Shibuya M, Watanabe M, Majima M. PloS one. 2014 9:e105533. (WB, Flo; Mouse) [Full Text Article] [PubMed:25162491] [PMC:PMC4146544]

Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy. Perales-Puchalt A, Perez-Sanz J, Payne KK, Svoronos N, Allegrezza MJ, Chaurio RA, Anadon C, Calmette J, Biswas S, Mine JA, Costich TL, Nickels L, Wickramasinghe J, Rutkowski MR, Conejo-Garcia JR. Journal of leukocyte biology. 2018 May;103:799-805. [Full Text Article] [PubMed:29537705] [PMC:PMC6004318] Related Antibodies: LS-C141892.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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