Mouse IL6 / Interleukin 6

Rat

Mouse (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

6B4 IGH 54

Unconjugated

Affinity purified

Preservative Free

Natural partially purified mouse IL-6.

Specific for mouse IL-6 (interleukin-6), a multifunctional pro-inflammatory cytokine secreted by activated T cells, macrophages, endothelial cells, fibroblasts and osteoblasts, which acts as the principle inducer of the acute phase response in the liver. IL-6 signals through a membrane bound receptor complex consisting of the ligand-binding IL-6Ralpha chain (CD126) and the signal-transducing component gp130 (CD130), but can also stimulate cells expressing gp130 through a soluble IL-6R. IL-6 has been shown to stimulate B cell differentiation and subsequent immunoglobulin production, promote hybridoma growth, as well as regulating bone metabolism and stimulating energy mobilization in muscle and fatty tissue. Clone 6B4 IGH 54 can be used to neutralize the activity of 50pg/ml of recombinant mouse IL-6 by >95% in a functional assay.

• ELISA

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

PBS

Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P05231 NCBI: NM_000600 NP_000591.1