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| Catalog Number | Size | Price |
|---|---|---|
| LS-B4912-0.1 | 0.1 mg (0.5 mg/ml) | $495 |
IHC‑plus™ Monoclonal Rat anti‑Mouse IL17 Antibody (clone TC11‑18H10, IHC, WB) LS‑B4912
IHC‑plus™ Monoclonal Rat anti‑Mouse IL17 Antibody (clone TC11‑18H10, IHC, WB) LS‑B4912
Note: This antibody replaces LS-C41753
Antibody:
IL17 Rat anti-Mouse Monoclonal (TC11-18H10) Antibody
Application:
IHC, IHC-P, WB, Flo, ELISA
Reactivity:
Mouse
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
IL17 Rat anti-Mouse Monoclonal (TC11-18H10) Antibody
Application:
IHC, IHC-P, WB, Flo, ELISA
Reactivity:
Mouse
Format:
Unconjugated, Unmodified
Specifications
Description
IL17 antibody LS-B4912 is an unconjugated rat monoclonal antibody to mouse IL17. Validated for ELISA, Flow, IHC and WB. Cited in 2 publications.
Host
Rat
Reactivity
Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgG1
Monoclonal
Clone
TC11-18H10
Conjugations
Unconjugated
Purification
Purified from ascites.
Modifications
Unmodified
Immunogen
E. coli-expressed, recombinant mouse IL-17A
Specificity
Recognizes mouse Interleukin 17, a 32kD disulfide-linked homodimer consisting of two 136 amino acid chains, which belong to the IL-17 family (classified as IL-17A to IL-17F), and signal through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.
Applications
- IHC
- IHC - Paraffin (10 µg/ml)
- Western blot
- Flow Cytometry
- ELISA
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
ELISA: This antibody can be used in a sandwich ELISA with LS-C41752 as a detection antibody.
Presentation
BBS
Storage
Store at -20°C. Avoid freeze-thaw cycles. Store undiluted.
Restrictions
For research use only. Intended for use by laboratory professionals.
Validation
Anti-IL-17 antibody IHC of mouse spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-IL-17 antibody IHC of mouse spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
See More About...
LSBio Ratings
IHC-plus™ IL17 Antibody (clone TC11-18H10) for IHC, WB/Western, Flow, ELISA LS-B4912 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (4)
Learn more about The LSBio Ratings Algorithm
Publications (2)
Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp. Gwanghui Ryu , Jun Sang Bae , Ji Hye Kim, Eun Hee Kim, Lele Lyu, Young Jun Chung, Ji Hun Mo. Allergy, asthma & immunology research. 2020 May;12:507-522.
Particulate Matter Exposure Aggravates IL-17-Induced Eye and Nose Inflammation in an OVA/Poly(I:C) Mouse Model. Jun-Sang Bae , Soo Bin Oh , Jeongyun Kim, Hoon Kim, Ji Hye Kim, Eun-Hee Kim, Kyong Jin Cho, Ji-Hun Mo. Allergy, asthma & immunology research. 2022 January;14:59-72.
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Requested From: United States
Date Requested: 4/20/2024
Date Requested: 4/20/2024
