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GRIN2B / NMDAR2B / NR2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged; memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity.
| Gene Name: | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
| Family/Subfamily: | Ion Channel , Glutamate receptor - ionotropic (NMDA receptor) |
| Synonyms: | GRIN2B, GluN2B, GluR epsilon 2, NMDA receptor 2B, NMDAR2B, NR2B, NR3, MRD6, HNR3 |
| Target Sequences: | NM_000834 NP_000825.2 Q13224 |
Publications (1)
1
Short-term dietary restriction maintains synaptic plasticity whereas short-term overfeeding alters cellular dynamics in the aged brain: evidence from the zebrafish model organism. Elif Tugce Karoglu-Eravsar, Melek Umay Tuz-Sasik, Michelle M Adams. Neurobiology of aging. 2021 October;106:169-182. [Full Text Article]
[PubMed:34284260]
Related Antibodies: LS-C25797.
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GRIN2B / NMDAR2B / NR2B
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(1)
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(1)
GRIN2B / NMDAR2B / NR2B Mouse anti-Rat Monoclonal (aa20-271) (S59-36) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
GRIN2B / NMDAR2B / NR2B Mouse anti-Rat Monoclonal (aa20-271) (Atto 488) (S59-36) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Atto 488 Conjugated
100 µg/$479
GRIN2B / NMDAR2B / NR2B Mouse anti-Rat Monoclonal (aa20-271) (Atto 390) (S59-36) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Atto 390 Conjugated
100 µg/$479
GRIN2B / NMDAR2B / NR2B Mouse anti-Rat Monoclonal (aa20-271) (Atto 594) (S59-36) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Atto 594 Conjugated
100 µg/$479
GRIN2B / NMDAR2B / NR2B Mouse anti-Rat Monoclonal (aa20-271) (AP) (S59-36) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
AP Conjugated
100 µg/$474
GRIN2B / NMDAR2B / NR2B Mouse anti-Human Monoclonal (B3-13B11) Antibody
Dog, Rat, Human, Monkey
ELISA, IHC, IHC-Fr, WB
Unconjugated
100 µg/$832
Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
GRIN2B / NMDAR2B / NR2B Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, WB
Unconjugated
10 µg/$469
GRIN2B / NMDAR2B / NR2B Rabbit anti-Mouse Polyclonal (aa1437-1456) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Human, Monkey
ELISA, WB
Unconjugated
250 µg/$995
GRIN2B / NMDAR2B / NR2B Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$564
GRIN2B / NMDAR2B / NR2B Mouse anti-Rat Monoclonal (aa20-271) (S59-36) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100 µg/$537
Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$958
GRIN2B / NMDAR2B / NR2B Rabbit anti-Rat Polyclonal (pTyr1472) Antibody
Chicken, Zebrafish, Rat, Bovine, Mouse, Dog, Human
WB
Unconjugated
100 µl/$469
Neuroscience
GRIN2B / NMDAR2B / NR2B Rabbit anti-Human Polyclonal (aa1435-1484) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
E. coli
His-GST, N-terminus
89 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
GRIN2B / NMDAR2B / NR2B Mouse anti-Human Monoclonal Antibody
Human
ICC, IHC, WB
Unconjugated
100 µg/$907
GRIN2B / NMDAR2B / NR2B Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
GRIN2B / NMDAR2B / NR2B Rabbit anti-Human Polyclonal (pTyr1474) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GRIN2B / NMDAR2B / NR2B Mouse anti-Human Monoclonal (aa20-271) (S59-20) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100 µg/$488
GRIN2B / NMDAR2B / NR2B Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$380
GRIN2B / NMDAR2B / NR2B Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
GRIN2B / NMDAR2B / NR2B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
GRIN2B / NMDAR2B / NR2B Mouse anti-Human Monoclonal (6E9A8) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µl/$459
GRIN2B / NMDAR2B / NR2B Rabbit anti-Human Polyclonal (pTyr1336) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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